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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Zika virus and safety of substances of human origin – A guide for preparedness activities in Europe

European Centre for Disease Prevention and Control (2016) CC

The objective of this document is to guide the preparation and implementation of national preparedness plans for the safety of substances of human origin during outbreaks of Zika virus infection, both in affected and non-affected areas.

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Interim National Guidelines for Monkeypox Outbreak Response

Federal Ministry of Health - Nigeria Centre for Disease Contro (2017) C2

This document provides information and recommendations for action, based on the current available knowledge around monkeypox. It is a first draft which will be updated in light of evolving evidence and additional information as they become available.

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Technical Guide: Sputum Examination for Tuberculosis by Direct Microscopy in Low-Income Countries

International Union Against Tuberculosis and Lung Disease (2000) C1

A technical guide for sputum smear microscopy, initiated by the International Union against Tuberculosis, is designed to be an easy to use reference standard for the collection, storage and transport of sputum specimens and for the examination of sputum smears by direct microscopy. This edition incl... more

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Collaborative Framework for Care and Control of Tuberculosis and Diabetes

International Union Against Tuberculosis and Lung Disease, World Health Organization (2015) C_WHO

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2nd International Conference on Re-emerging Infectious Diseases: Scientific Report

African Union; Africa CDC Centres for Disease Control and Prevention Africa CDC (2019) C_CDC

In 2007, WHO warned that infectious diseases are emerging and re-emerging at a rate that has not been seen before. The potential for infectious diseases to spread rapidly results in high morbidity and mortality, causing a potential global public health treat of major concern. Several factors are ... more

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Nigeria: Preparedness and Response to Acute Watery Diarrhoea Outbreaks

Federal Ministry of Health - Nigeria Centre for Disease Control (2017) C2

A GUIDE FOR HEALTH WORKERS AND AUTHORITIES IN NIGERIA

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COVID-19 Infection Prevention and Control: Your Questions Answered
recommended

African Union; Africa CDC Centres for Disease Control and Prevention (2020) CC

In the strategies for effective infection prevention and control (IPC), what does triage entail at hospitals? Triage includes screening at the entrance, identification of cases and isolation if necessary. There should be a triage (screening) area where visitors to the hospital are interviewed using... more

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Philippine Health Advisories

Department of Health, National Center for Health Promotion, National Center for Disease Prevention and Control (2012) C1

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Policy for Tuberculosis Control in Substance Abuse Treatment Centers

M. Botticelli (Bureau of Substance Abuse Services); K. Cranston, A. DeMaria (Bureau of Infectious Disease); et al. Massachusetts Department of Public Health (2009) C2

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Tuberculosis - A manual for medical students

N. Ait-Khaled, D. Enarson World Health Organization; International Union Against Tuberculosis and Lung Disease (1999) C_WHO

WHO/CDS/TB/99.272

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Introduction to HIV, AIDS and STI Surveillance - HIV Clinical Staging and Case Reporting

United States Department of Health and Human Services; Centers for Disease Control and Prevention (HHS-CDC); Global AIDS Program (GAP); et al. United States Department of Health and Human Services; Centers for Disease Control and Prevention (HHS-CDC); Global AIDS Program (GAP); et al. (2009) C2

Participant Manual September 2009

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National Guidelines for Infection Prevention and Control in Healthcare Facilities

Ministry of Health & Family Welfare Government of India; National Centre for Disease Control (2020) C2

Infection Prevention and Control Programmes January 2020

External Link

WHO/Europe and ECDC Monkeypox Surveillance Bulletin
recommended

World Health Organization WHO, Regional Office of Europe; European Center for Disease Control ECDC (2022) C_WHO

Here you can find the latest reports

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Pertussis Vaccine-Preventable Diseases Surveillance Standards

World Health Organization WHO (2018) C_WHO

The objectives of pertussis surveillance are to:hmonitor disease burden and the impact of the pertussis vaccination programme, with a special focus on understanding the morbidity and mortality in children < 5 years of agehgenerate data to inform vaccine schedule and delivery strategy decisions to op... more

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Situation Analysis Antibiotic Use and Resistance in India

Public Health Foundation India (2011) C2

The infectious disease burden in India is among the highest in the world. A large amount of antibiot-ics are consumed in fighting infections, some of them saving lives, but every use adding to antibiotic resistance in bacteria. Antibiotic use is increasing steadily (table 1), particularly ... more

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Use of antibiotics for the treatment and control of cholera
recommended

Global Task Force for Cholera Control (2018) C1

Cholera is an acute diarrhoeal disease caused by the ingestion of food or water contaminated with the bacterium V. cholerae. It has a short incubation period of a few hours to 5 days. It is endemic in some countries, frequently showing seasonal variations in the number of reported cases. Cholera a... more

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Fighting Cholera - Operational Handbook: Response to outbreaks and risk prevention in endemic areas

Solidarités International (2018) CC

Cholera is a diarrhoeal disease that is usually contracted when drinking water contaminated with Vibrio cholerae bacteria. The fight against this disease requires a multidisciplinary approach that combines a water, hygiene and sanitation (WaSH) response with a monitoring system, improved water suppl... more

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Delivery of cardiology services in Africa during the COVID-19 pandemic: what should we expect after this pandemic?

Nganou-Gnindjio, C.N.; Temgoua, M.N.; Kuate, L.M. et al. (2021) CC

Background: COVID-19 is a global public health crisis that affects all sectors; studying the impact of this pandemic on the delivery of cardiology services in Africa is crucial as COVID-19-related cardiovascular complications may worsen the CVD burden in this already highly affected and resource-lim... more

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Handbook for the Management of Public Health Events in Air Transport

World Health Organization WHO (2016) C_WHO

Updated with information on Ebola virus disease and Middle East respiratory syndrome coronavirus A wide variety of health events ranging in severity may occur related to air transport, requiring different responses or, perhaps, no response at all. The target audience for this guidance document incl... more

COVID-19 Infection Prevention and Control: Your Questions Answered recommended

WHO/Europe and ECDC Monkeypox Surveillance Bulletin recommended

Use of antibiotics for the treatment and control of cholera recommended

COVID-19 Infection Prevention and Control: Your Questions Answered
recommended

WHO/Europe and ECDC Monkeypox Surveillance Bulletin
recommended

Use of antibiotics for the treatment and control of cholera
recommended