Leptospirosis is a perplexing conundrum for many. In the existing literature, the pathophysiological mechanisms pertaining to leptospirosis is still not understood in full. Considered as a neglected tropical zoonotic disease, leptospirosis is culminating as a serious problem worldwide, seemingly exi...sting as co-infections with various other unrelated diseases, including dengue and malaria. Misdiagnosis is also common as non-specific symptoms are documented extensively in the literature. This can easily lead to death, as the severe form of leptospirosis (Weil’s disease) manifests as a complex of systemic complications, especially renal failure. The virulence of Leptospira sp. is usually attributed to the outer membrane proteins, including LipL32. With an armament of virulence factors at their disposal, their ability to easily adhere, invade and replicate within cells calls for a swift refinement in research progress to establish their exact pathophysiological framework. As an effort to reconstitute the current knowledge on leptospirosis, the basis of leptospiral infection, including its risk factors, classification, morphology, transmission, pathogenesis, co-infections and clinical manifestations are highlighted in this review. The various diagnostic techniques are also outlined with emphasis on their respective pros and cons.
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Раннее выявление туберкулеза среди представителейгрупп риска
Пособие по проведению тренинга
Epidemiol Infect. May 2007; 135(4): 610–621. . Please click on the website link and download the pdf-file. Open Access
n this study, low-dose azithromycin did not meet the prespecified non-inferiority margin compared with standard-dose azithromycin in achieving clinical and serological cure in PCR-confirmed active yaws. Only a single participant (with presumed latent yaws) had definitive serological failure. This wo...rk suggests that 20 mg/kg of azithromycin is probably effective against yaws, but further data are needed.
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African Journal of Primary Health Care & Family Medicine
ISSN: (Online) 2071-2936, (Print) 2071-2928
Rapporto ISS COVID-19, n. 3/2020
Gruppo di Lavoro ISS Ambiente e Gestione dei Rifiuti
aggiornato al 14 marzo 2020
N Engl J Med 2014; 371:2083-2091November 27, 2014DOI: 10.1056/NEJMoa1411099
Free Download from the website http://www.nejm.org/doi/full/10.1056/NEJMoa1411099?query=TOC
Rapporto ISS COVID-19, n. 4/2020
Gruppo di Lavoro ISS Prevenzione e Controllo delle Infezioni
aggiornato al 16 marzo 2020
El protocolo se entiende como el documento que traduce el acuerdo entre profesionales expertos en un determinado tema, en el que se detallan las actividades a realizar ante una determinada situación. Es un documento dinámico que necesita ser revisado periódicamente, y que debe incorporar el mejor... conocimiento sistematizado y disponible en la materia. Sus propósitos principales son brindar a los usuarios de los servicios de salud de los centros de privación de libertad una atención de calidad, poniendo a disposición del equipo de salud diferentes herramientas que ayuden a tomar decisiones en momentos de incertidumbre, contribuyan a normalizar la práctica disminuyendo la variabilidad de las intervenciones, y sean fuente de información facilitando el desempeño del personal que se incorpora a los servicios.
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The aim of the present study was to predict which patients with severe or difficult-to-treat asthma are at highest risk for healthcare utilisation can be predicted so as to optimise clinical management. Data were derived from 2,821 adults with asthma enrolled in The Epidemiology and Natural History ...of Asthma: Outcomes and Treatment Regimens (TENOR) study. Multiple potential predictors were assessed at baseline using a systematic algorithm employing stepwise logistic regression. Outcomes were asthma-related hospitalisations or emergency department (ED) visits within 6 months following baseline.
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The Lancet Volume 384, Issue 9960p2142-2152December 13, 2014
This article is available free of charge. Log in or register for free to read the full article.
Front. Public Health, 02 July 2019 Sec. Infectious Diseases: Epidemiology and Prevention
Volume 7 - 2019 | https://doi.org/10.3389/fpubh.2019.00166
Chagas disease (CD) is an anthropozoonosis caused by the protozoan parasite Trypanosoma cruzi, that affects about 6–8 million people worldwide (1) a...nd causes approximately 50,000 deaths per year. Another 65–100 million people are living in areas at risk for infection worldwide (2–4). Even though over a century has passed since its discovery, CD remains one of the leading public health problems for most Latin American countries
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Case study
Alliance Ukraine’s experience integrating HIV, harm reduction and sexual and reproductive health programming
Indicazioni ad interim - Per un utilizzo regionale delle protezioni per infezione da SARS-CoV-2 nelle attività sanitarie e sociosanitarie (Assistenza a soggetti affetti da CoVID-19) nell’attuale scenario emergenziale SARS-CoV-2
Rapporto ISS COVID-19, n. 5/2020
Gruppo di Lavoro ISS Ambiente e Qualità dell’Aria Indoor
versione del 23 marzo 2020
The Malaria Prevention Campaign, launched in Oromia Region of Ethiopia recognized communities for taking specific actions to combat malaria. The focus of the campaign was around small, doable actions that families carry out to protect themselves against malaria. The community volunteers under direct...ion from the Community Mobilization Committee (CMC) energized and supported their communities, families, and schools to take the actions necessary to prevent malaria.
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Conjunto de Guías sobre Servicios y Politicas de Salud Mental
Editores Médicos, s.a. EDIMSA. 2005