Mem Inst Oswaldo Cruz . 2021 Jan 29;115:e200287. doi: 10.1590/0074-02760200287. eCollection 2021. Sensitivity and negative predictive value were directly affected by sample storage conditions. RT-PCR and virus isolation showed greater dependence on well-conserved samples for an accurate diagnosis
Two decades of epidemiological research shows that silent cerebrovascular disease is common and is associated with future risk for stroke and dementia. It is the most common incidental finding on brain scans. To summarize evidence on the diagnosis and management of silent cerebrovascular disease to ...prevent stroke, the Stroke Council of the American Heart Association convened a writing committee to evaluate existing evidence, to discuss clinical considerations, and to offer suggestions for future research on stroke prevention in patients with 3 cardinal manifestations of silent cerebrovascular disease: silent brain infarcts, magnetic resonance imaging white matter hyperintensities of presumed vascular origin, and cerebral microbleeds. The writing committee found strong evidence that silent cerebrovascular disease is a common problem of aging and that silent brain infarcts and white matter hyperintensities are associated with future symptomatic stroke risk independently of other vascular risk factors. In patients with cerebral microbleeds, there was evidence of a modestly increased risk of symptomatic intracranial hemorrhage in patients treated with thrombolysis for acute ischemic stroke but little prospective evidence on the risk of symptomatic hemorrhage in patients on anticoagulation. There were no randomized controlled trials targeted specifically to participants with silent cerebrovascular disease to prevent stroke. Primary stroke prevention is indicated in patients with silent brain infarcts, white matter hyperintensities, or microbleeds. Adoption of standard terms and definitions for silent cerebrovascular disease, as provided by prior American Heart Association/American Stroke Association statements and by a consensus group, may facilitate diagnosis and communication of findings from radiologists to clinicians.
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PLOS Medicine | DOI:10.1371/journal.pmed.1002088 August 23, 2016
Leptospirosis is a perplexing conundrum for many. In the existing literature, the pathophysiological mechanisms pertaining to leptospirosis is still not understood in full. Considered as a neglected tropical zoonotic disease, leptospirosis is culminating as a serious problem worldwide, seemingly exi...sting as co-infections with various other unrelated diseases, including dengue and malaria. Misdiagnosis is also common as non-specific symptoms are documented extensively in the literature. This can easily lead to death, as the severe form of leptospirosis (Weil’s disease) manifests as a complex of systemic complications, especially renal failure. The virulence of Leptospira sp. is usually attributed to the outer membrane proteins, including LipL32. With an armament of virulence factors at their disposal, their ability to easily adhere, invade and replicate within cells calls for a swift refinement in research progress to establish their exact pathophysiological framework. As an effort to reconstitute the current knowledge on leptospirosis, the basis of leptospiral infection, including its risk factors, classification, morphology, transmission, pathogenesis, co-infections and clinical manifestations are highlighted in this review. The various diagnostic techniques are also outlined with emphasis on their respective pros and cons.
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Раннее выявление туберкулеза среди представителейгрупп риска
Пособие по проведению тренинга
Epidemiol Infect. May 2007; 135(4): 610–621. . Please click on the website link and download the pdf-file. Open Access
n this study, low-dose azithromycin did not meet the prespecified non-inferiority margin compared with standard-dose azithromycin in achieving clinical and serological cure in PCR-confirmed active yaws. Only a single participant (with presumed latent yaws) had definitive serological failure. This wo...rk suggests that 20 mg/kg of azithromycin is probably effective against yaws, but further data are needed.
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African Journal of Primary Health Care & Family Medicine
ISSN: (Online) 2071-2936, (Print) 2071-2928
Rapporto ISS COVID-19, n. 3/2020
Gruppo di Lavoro ISS Ambiente e Gestione dei Rifiuti
aggiornato al 14 marzo 2020
N Engl J Med 2014; 371:2083-2091November 27, 2014DOI: 10.1056/NEJMoa1411099
Free Download from the website http://www.nejm.org/doi/full/10.1056/NEJMoa1411099?query=TOC
Rapporto ISS COVID-19, n. 4/2020
Gruppo di Lavoro ISS Prevenzione e Controllo delle Infezioni
aggiornato al 16 marzo 2020
El protocolo se entiende como el documento que traduce el acuerdo entre profesionales expertos en un determinado tema, en el que se detallan las actividades a realizar ante una determinada situación. Es un documento dinámico que necesita ser revisado periódicamente, y que debe incorporar el mejor... conocimiento sistematizado y disponible en la materia. Sus propósitos principales son brindar a los usuarios de los servicios de salud de los centros de privación de libertad una atención de calidad, poniendo a disposición del equipo de salud diferentes herramientas que ayuden a tomar decisiones en momentos de incertidumbre, contribuyan a normalizar la práctica disminuyendo la variabilidad de las intervenciones, y sean fuente de información facilitando el desempeño del personal que se incorpora a los servicios.
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The aim of the present study was to predict which patients with severe or difficult-to-treat asthma are at highest risk for healthcare utilisation can be predicted so as to optimise clinical management. Data were derived from 2,821 adults with asthma enrolled in The Epidemiology and Natural History ...of Asthma: Outcomes and Treatment Regimens (TENOR) study. Multiple potential predictors were assessed at baseline using a systematic algorithm employing stepwise logistic regression. Outcomes were asthma-related hospitalisations or emergency department (ED) visits within 6 months following baseline.
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The Lancet Volume 384, Issue 9960p2142-2152December 13, 2014
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Front. Public Health, 02 July 2019 Sec. Infectious Diseases: Epidemiology and Prevention
Volume 7 - 2019 | https://doi.org/10.3389/fpubh.2019.00166
Chagas disease (CD) is an anthropozoonosis caused by the protozoan parasite Trypanosoma cruzi, that affects about 6–8 million people worldwide (1) a...nd causes approximately 50,000 deaths per year. Another 65–100 million people are living in areas at risk for infection worldwide (2–4). Even though over a century has passed since its discovery, CD remains one of the leading public health problems for most Latin American countries
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Case study
Alliance Ukraine’s experience integrating HIV, harm reduction and sexual and reproductive health programming
Indicazioni ad interim - Per un utilizzo regionale delle protezioni per infezione da SARS-CoV-2 nelle attività sanitarie e sociosanitarie (Assistenza a soggetti affetti da CoVID-19) nell’attuale scenario emergenziale SARS-CoV-2