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Publication Years
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2521
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Category
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Toolboxes
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1
The document “Mpox Continental Response Plan 2.0” outlines the strategy developed by the Africa Centres for Disease Control and Prevention (Africa CDC) in collaboration with the World Health Organization (WHO) to respond to the ongoing mpox outb
...
reak across Africa. The plan describes coordinated actions to strengthen surveillance, laboratory capacity, case detection and contact tracing in affected countries. It also focuses on improving access to vaccines, diagnostics and treatment, supporting healthcare systems, and enhancing risk communication and community engagement. In addition, the document highlights the importance of regional and international cooperation, resource mobilization and technical support to help African countries control the outbreak and prevent further spread. Overall, the plan serves as a continental framework to guide a coordinated public health response to mpox in Africa.
more
A survey was conducted in countries in all six WHO regions and focused on the building blocks that are considered prerequisites to combat antimicrobial resistance: a comprehensive national plan, laboratory capacity to undertake surveillance for resi
...
stant microorganisms, access to safe, effective antimicrobial medicines, control of the misuse of these medicines, awareness and understanding among the general public and effective infection prevention and control programmes.
more
The document provides a standardized protocol for evaluating the Early Warning Alert and Response Network (EWARN), a surveillance system used during humanitarian emergencies when regular national health surveillance may be disrupted. The purpose of
...
EWARN is to detect outbreaks of communicable diseases early and enable rapid public health response. The guidance explains how the system should be assessed in terms of its structure, implementation, effectiveness, and usefulness. It outlines the key steps of evaluation: preparation, system description, data collection, and post-evaluation reporting. The protocol highlights common challenges observed in previous EWARN implementations, such as delays in establishing the system, limited data quality, weak outbreak response, and lack of clear transition plans back to routine surveillance systems. It emphasizes the need to evaluate both weekly disease reporting and alert verification processes, and to review attributes such as simplicity, data quality, timeliness, sensitivity, and stability. The document also provides templates for interviews, data review forms, and laboratory assessment, as well as guidance on conducting remote evaluations when access is limited. The overall goal of the protocol is to ensure that EWARN functions effectively to detect and respond to outbreaks and that practical recommendations are developed to improve the system’s performance and sustainability in emergency settings.
more
The document “Hospital Preparedness for Epidemics” published by the World Health Organization (WHO) provides guidance on how hospitals and healthcare facilities can prepare for and respond effectively to infectious disease outbreaks. It outlines
...
key components of epidemic preparedness, including planning and management structures, infection prevention and control, communication systems, human resource management, logistics, laboratory capacity, and the continuity of essential health services. The guide emphasizes the importance of coordination within hospitals and with public health authorities, as well as training staff and ensuring adequate supplies and infrastructure. Overall, the document serves as a practical framework to help hospitals strengthen their readiness, maintain critical healthcare services, and respond efficiently during epidemics or other health emergencies.
more
The WHO Cholera Rapid Diagnostic Test (RDT) Target Product Profile outlines the key requirements for developing improved cholera RDTs. It highlights the need for fast, accurate, and easy-to-use tests for early outbreak detection in resource-limited settings. The document sets desired and acceptable
...
performance criteria, including high sensitivity and specificity, rapid results (under 15 minutes), and usability by non-laboratory personnel. The tests should be affordable, stable in extreme conditions, and require minimal training. The goal is to enhance cholera surveillance and outbreak response, ensuring quick containment and improved public health outcomes.
more
The following protocol has been designed to investigate the extent of infection, as determined by seropositivity in the general population, in any country in which COVID-19 virus infection has been reported. Each country may need to tailor some aspects of this protocol to align with
...
public health, laboratory and clinical systems, according to capacity, availability of resources and cultural appropriateness. However, using a standardized protocol such as this one below, epidemiological exposure data and biological samples can be systematically collected and shared rapidly in a format that can be easily aggregated, tabulated and analyzed across many different settings globally for timely estimates of COVID-19 virus infection severity and attack rates, as well as to inform public health responses and policy decisions. This is particularly important in the context of a novel respiratory pathogen, such as COVID-19 virus
more
When situations occur in which unwanted events are rightly or wrongly connected with vaccination, they may erode confidence in vaccines and the authorities delivering them. This document presents the scientific evidence behind WHO’s recommendations on building and restoring confidence in vaccines
...
and vaccination, both in ongoing work and during crises. The evidence draws on a vast reserve of laboratory research and fieldwork within psychology and communication. It examines how people make decisions about vaccination; why some people are hesitant about vaccination; and the factors that drive a crisis, covering how building trust, listening to and understanding people, building relations, communicating risk and shaping messages to the audiences may mitigate crises. This document provides a knowledge base for stakeholders who develop communication strategies or facilitate workshops on communication and trust-building activities in relation to vaccines and immunization, such as immunization programme units, ministries of health, public relations and health promotion units, vaccine safety communication trainers and immunization advisory bodies.
more
Despite the development of point-of-care diagnostic tests for syphilis, chlamydia, gonorrhoea, and trichomoniasis, none comply with all WHO criteria. This analysis overviews landscape analyses of point-of-care diagnostic technologies for Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vagi
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nalis and syphilis, available and in the pipeline. The target audience for the target product profiles is broad and includes clinicians, researchers working on diagnostics, laboratory experts, including, microbiologists and virologists, public health experts, epidemiologists, developers, and representatives for manufactures, including biotech engineers, policy-and decision-makers as well as representatives from regulatory bodies and agencies, donor agencies and international organizations.
more
The webpage ”H5 Reference Laboratories” on the WHO Global Influenza Surveillance and Response System (GISRS) site describes a network of specialized laboratories designated by the World Health Organization to support global influenza monitoring
...
— particularly for H5 subtype avian influenza viruses.
It explains that these reference laboratories perform high-level testing, characterization, and sharing of influenza virus samples, including genetic sequencing and antigenic analysis. Their role is to help detect and assess influenza virus strains of public health concern (especially H5 strains with pandemic potential), support vaccine strain selection, and provide technical guidance and capacity building to national influenza centers and other laboratories. The page highlights the importance of this global laboratory network in strengthening early warning, risk assessment, and preparedness for influenza outbreaks and pandemics.
more
The Marburg Virus Disease (MVD) Response Plan outlines Tanzania’s national strategy for responding to a Marburg virus outbreak declared in the Kagera Region in January 2025. The document describes the current epidemiological situation, assesses the risks posed by the outbreak, and sets strategic o
...
bjectives to contain the disease and prevent further transmission. It details response measures across multiple sectors, including surveillance, laboratory testing, case management, infection prevention and control, risk communication, logistics, and community engagement. Furthermore, the plan defines coordination mechanisms, operational procedures, monitoring indicators, and the financial resources required to implement the response. Overall, the plan serves as a comprehensive framework to guide national and international stakeholders in controlling the outbreak and protecting public health.
more
The document outlines comprehensive guidelines for managing cholera outbreaks in South Africa, focusing on prevention, diagnosis, treatment, and public health measures. It emphasizes the importance
...
of rehydration therapy, sanitation, clean water access, and community involvement to control the spread of the disease. It also provides protocols for handling outbreaks, including case identification, laboratory confirmation, and multi-sectoral coordination to reduce morbidity and mortality rates.
more
DPDx - Laboratory Identification of Parasites of Public Health Concern
Trypanosoma cruzi, is a parasitic protozoan that is the causative agent of
...
Chagas disease (American trypanosomiasis). Currently, six distinct lineages of T. cruzi are classified into discrete typing units (TcI-VI), which vary in their geographic occurrence, host specificity, and pathogenicity.
more
DPDx Laboratory Identification of Parasites of Public Health Concerns
Including Life cycle
Africa CDC Institute of Pathogen Genomics (IPG) was launched in November 2019 and operates under the Division of Laboratory Systems and Networks.
IPG coordinate the implementation of molecular diagnostics, pathogen genomics and bioinformatics in Na
...
tional Public Health Institutions (NPHIs) and/or Refe-
-rence Laboratories (NRLs) across Africa.
Africa CDC and APHF are coordinating a continental initiative to maximize the benefits of molecular approaches and pathogen genomics for more effective
outbreak preparedness, prevention, response, and for the control and elimination of endemic diseases in Africa. One of Africa CDC’s flagship initiative is the Africa
Pathogen Genomics Initiative (Africa PGI), a partnership that aims to strengthen laboratory systems and enhance genomic surveillance by equipping the continent’s
public health institutions with the tools, training, and data infrastructure.
About the Project
In 2023, 166 outbreaks and public health events were reported in Africa. This calls for a resilient laboratory systems for timely detection and reporting of current and future outbreaks. This project aims to scale up molecular diagnostic and genomic sequencing-based detection and characterization of outbreaks.
Africa CDC is working with Member States to develop guidance, diagnostic algorithm, training and capacity building to enable outbreak detection, and reporting to inform public health response.
more
The present DHR-ICMR guidelines comprehensively address the various concerns regarding the clinical assessment, treatment, and laboratory diagnosis of rickettsial diseases in India and the world. It is hoped that physicians,
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health care workers, the scientific community, the regulatory agencies, public health care professionals and the public at large will be benefited by these guidelines.
more
The document “Guidelines for the Investigation and Control of Disease Outbreaks” provides practical guidance for public health professionals on how to detect, investigate, and manage outbreaks o
...
f communicable diseases. It describes the key steps of outbreak investigation, including confirming the outbreak, establishing a case definition, collecting epidemiological and laboratory data, identifying the source and mode of transmission, and implementing control measures. The guidelines also explain how to organize outbreak response teams, communicate findings, and document results in outbreak reports. Overall, the document aims to support systematic and effective outbreak investigations in order to control disease spread and protect public health.
more
The document “Guidelines for Writing Outbreak Investigation Reports” by the European Centre for Disease Prevention and Control provides practical guidance on how to prepare clear, structured, and scientifically sound reports after investigating a disease outbreak. It is mainly intended for epide
...
miologists and public health professionals, particularly participants in the ECDC Fellowship Programme. The guide explains the purpose of outbreak investigation reports and describes the recommended structure and content of such reports, including sections such as background, objectives, methods, results, and conclusions. It also outlines how to present epidemiological, laboratory, and environmental findings, interpret the results, and formulate public health recommendations. Overall, the document aims to standardize outbreak reporting, improve the quality and clarity of reports, and ensure that investigation findings can effectively support public health decision-making and future outbreak prevention.
more
The protozoan parasite Trypanosoma cruzi causes Chagas disease, an important public health problem throughout Latin America. Current therapeutic options are characterised by limited efficacy, long t
...
reatment regimens and frequent toxic side-effects. Advances in this area have been compromised by gaps in our knowledge of disease pathogenesis, parasite biology and drug activity. Nevertheless, several factors have come together to create a more optimistic scenario. Drug-based research has become more systematic, with increased collaborations between the academic and commercial sectors, often within the framework of not-for-profit consortia. High-throughput screening of compound libraries is being widely applied, and new technical advances are helping to streamline the drug development pipeline. In addition, drug repurposing and optimisation of current treatment regimens, informed by laboratory research, are providing a basis for new clinical trials. Here, we will provide an overview of the current status of Chagas disease drug development, highlight those areas where progress can be expected, and describe how fundamental research is helping to underpin the process.
more
Responding to a polio outbreak. Guidelines
recommended
The occurrence of a case of wild polio in a previously polio free area as presently in Syria, whether through importation, laboratory accident, or mutation of vaccine virus (VDPV), should be considered a p
...
ublic health emergency, that requires a rapid and high quality response as utmost priority
more
The 6th edition of the essential medicine list has been developed based on the 5th edition list of essential medicines, the National Standard Treatment Guidelines and Protocols 2013, list of laboratory commodities and List of Consumables used in
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public health facilities.
more
