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The Zambia Population Based HIV impact assessment of 2016, reported the prevalence of viral hepatitis in Zambia as ranging between 5.6% among adults aged 15 to 59% in the general population, and 7.1% among
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HIV infected individuals. It is estimated that the majority of persons with chronic hepatitis B and/ or hepatitis C are unware of their infection and do not benefit from promotive, preventive and curative services designed to reduce onward transmission. Zambia introduced hepatitis B virus vaccine to the routine Under 5 vaccination schedule in 2005. Preliminary results from the ZAMPHIA indicate that hundreds of infections have been abated in children since then. However, its also clear that we continue to miss key opportunities to prevent transmission, diagnose and treat infections, prevent serious disease, and in many cases cure people. In addition, high risk groups inter alia health care workers still have limited access to the vaccine.
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Treatment and care in children and adolescents
recommended
WHO recommends that infants born to mothers living with HIV are tested for HIV by two months of age, during breastfeeding, and when breastfeeding ends given continued risk of
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transmission during this period. Older children, especially offspring and siblings of persons infected with HIV, should also be tested in high prevalence regions. Community-based outreach and testing can improve access to testing while mitigating HIV-related stigma.
Children living with HIV should start antiretroviral treatment (ART) immediately
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Journal of the International AIDS Society Vol. 21 (2018) e25133
Many prevention of mother-to-child HIV transmission programmes across Africa initiate ... HIV-infected (HIV positive) pregnant women on lifelong antiretroviral therapy (ART) on the first day of antenatal care (“same-day” initiation). However, there are concerns that same-day initiation may limit patient preparation before starting ART and contribute to subsequent non-adherence, disengagement from care and raised viral load. We examined if same-day initiation was associated with viral suppression and engagement in care during pregnancy.
The data suggest that same-day ART initiation during pregnancy is not associated with lower levels of engagement in care or viral suppression through 12 months post-delivery in this setting, providing reassurance to ART programmes implementing Option B+.
https://doi.org/10.1002/jia2.25133 more
Many prevention of mother-to-child HIV transmission programmes across Africa initiate ... HIV-infected (HIV positive) pregnant women on lifelong antiretroviral therapy (ART) on the first day of antenatal care (“same-day” initiation). However, there are concerns that same-day initiation may limit patient preparation before starting ART and contribute to subsequent non-adherence, disengagement from care and raised viral load. We examined if same-day initiation was associated with viral suppression and engagement in care during pregnancy.
The data suggest that same-day ART initiation during pregnancy is not associated with lower levels of engagement in care or viral suppression through 12 months post-delivery in this setting, providing reassurance to ART programmes implementing Option B+.
https://doi.org/10.1002/jia2.25133 more
The Ministry of Health through the National AIDS Secretariat, has developed the Strategic Operational Plan for Condom Programming in Sierra Leone with a focus on reinvigorating condom use to ensure “uninterrupted access to male and female condoms and lubricants for Key Populations, young people an
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d the general population.” Condom use in the country was estimated at 7 per cent and 23 per cent of women and men respectively who had sexual intercourse with non-regular partners. The primary goal of the strategic operational plan is to enhance access and utilization of male and female condoms, supporting national efforts to reduce the transmission of sexually transmitted infections (STIs), including HIV, and unintended pregnancies, for all sexually active individuals.
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Geographical, landscape and host associations of Trypanosoma cruzi DTUs and lineages
Izeta-Alberdi, A.; Ibarra-Cerdena, C.; Moo-llanes, D.; Ramsey,J.
BMC Part of Springer Nature
(2016)
CC
Trypanosoma cruzi is the etiological agent of Chagas disease (CD), considered one of the most important parasitic infections in Latin America. Between 25 and 90 million humans are at infection risk via at least one of multiple infection mechanisms. Under natural conditions, the principal
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transmission modes are transplacental or via one of more than 140 hematophagous triatomine bugs (Reduviidae: Triatominae). Triatomines acquire the parasite from mammal reservoirs due to their obligate blood-feeding (albeit triatomines can also feed on non-reservoir vertebrates such as birds and reptiles). The disease burden for CD in the Latin America and Caribbean region, based on disability-adjusted life-years (DALYs), is at least five times greater than that of malaria, and is approximately one-fifth that of HIV/AIDS. In recent decades, CD has extended to other continents outside natural reservoir or vector distributions due to human migration, with a minimum estimated 10 million individuals infected worldwide.
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During the year 2022, COVID-19 continued to be a significant challenge in Eritrea as in many other countries across the world. As COVID-19 devastated communities around the world, WHO worked with the MoH to strengthen the National and Sub-National health systems in order to meet community needs and
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mitigate the devastation during the pandemic and beyond.
One of the major achievements in the year 2022 was the beginning of the journey towards validation of
the elimination of mother to child transmission of HIV, syphilis, and hepatitis B. This is the culmination of years
of commitment and determination by the political leadership, national and international partnerships to
reduce the associated indices to levels that qualify for elimination.
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This selection of online courses provides a comprehensive education in malaria and related infectious diseases, set within the broader frameworks of global health and epidemiology. Courses such as the Global Disease Masterclass and Immunology: The Immune System and Infectious Diseases (both offered
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by Imperial College London on Coursera), explore malaria alongside diseases such as HIV, tuberculosis and emerging infections. Spanning several weeks, they provide insights into disease dynamics, immune responses, and public health interventions, and are suitable for learners from beginner to intermediate levels.
Specialised courses such as 'Medical Entomology' from the Institut Pasteur focus on mosquito vectors and parasite transmission, which are critical to malaria control. Additionally, French-language courses such as 'Le paludisme' from Aix-Marseille Université offer in-depth knowledge of malaria biology, prevention and treatment strategies.
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Detailed clinical guidelines focusing on dolutegravir-based regimens.
The Lancet HIV Volume 11, Issue 1e3-e4January 2024
Les piliers adoptés pour le plan AEVT sont les suivants : a) dépistage précoce chez les enfants exposés au VIH, à la syphilis et au VHB ; b) réduction des inégalités en matière de traitement chez les PBFW et les enfants exposés au VIH, à la syphilis et au VHB ; c) prévention des nouvelle
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s infections par le VIH, la syphilis et le VHB chez les PBFW ; et d) élimination des obstacles à l'accès à des services intégrés. Sur la base de ces piliers, le plan AEVT guide la mobilisation politique pour franchir la dernière étape vers l'élimination de la transmission verticale du VIH, de la syphilis et du VHB en Afrique d'ici 2030
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Demographic and socioeconomic data Progress towards HIV testing and treatment cascade targets by 2025 (2023) Health sector cascade (2023) Estimated number of people newly infected with HIV
Int. J. Transl. Med. 2023, 3(2), 187-202; https://doi.org/10.3390/jtm3020014 .
Malaria and HIV are geographically in the tropics and subtropics of the world, including sub-Saharan Africa. Understanding the overlapping effect of both infections, esp
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ecially among pregnant women, is crucial in managing pregnant women during antenatal care visits, and postpartum babies. It was realized that the prevalence of malaria among HIV-positive pregnant women ranges between 31–61%, while for non-HIV infected pregnant women the prevalence still stands between 10 and 36%. Co-infection is between 0.52 and 56.3%.
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This report describes efforts in nine countries, supported by the 2gether 4 SRHR programme and other partners, highlighting the results achieved and learning on improving the health and wellbeing of adolescent and young mothers and their families. Key insights include the importance of responsive se
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rvice delivery and social support as well as service provision across sectors.
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Strategies to improve retention of mother-baby pairs in PMTCT programs
K. Achebe; A. Isehak; R. A. Golin; et al.
Children & AIDS; Unicef; Save the Children; et al.
(2019)
C2
The majority of MBPs not retained in prevention of mother-to-child transmission (PMTCT) programs are due to loss to follow-up (LTFU).
This clinical job aid addresses the importance of maternal health and antiretroviral therapy adherence, as well as care and testing for the HIV-exposed infant until the infant’s final HIV diagnosi
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s after the end of breastfeeding.
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