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Epidemiology
Chagas disease (American trypanosomiasis) is caused by the protozoan parasite Trypanosoma cruzi, and transmitted to humans by infected triatomine bugs, and less commonly by transfusion
...
, organ transplant, from mother to infant, and in rare instances, by ingestion of contaminated food or drink.1-4 The hematophagous triatomine vectors defecate during or immediately after feeding on a person. The parasite is present in large numbers in the feces of infected bugs, and enters the human body through the bite wound, or through the intact conjunctiva or other mucous membrane.
Vector-borne transmission occurs only in the Americas, where an estimated 8 to 10 million people have Chagas disease.5 Historically, transmission occurred largely in rural areas in Latin America, where houses built of mud brick are vulnerable to colonization by the triatomine vectors.4 In such areas, Chagas disease usually is acquired in childhood. In the last several decades, successful vector control programs have substantially decreased transmission rates in much of Latin America, and large-scale migration has brought infected individuals to cities both within and outside of Latin America.
more
Zambia has completed the implementation of the National TB Strategic Plan (2017-2021) that set in motion the TB elimination agenda in Zambia through coordinated and accelerated TB response. During this period, the National TB
...
and Leprosy Programme (NTLP) registered tremendous success.
The NTLP is poised to attain the ambitious goal pronounced by the government of eliminating TB by 2030, in line with the Sustainable Development Goals (SDGs) and the World Health Organization End TB Strategy. The programme exponentially increased TB notifications from as low as 35,922 people with TB in 2018 to 40,726 in 2020 and in 2021 the TB notifications rose to 50,825 (a 25% increase against 2020 performance). The NTLP also registered incredible success in sustaining high TB Preventive Treatment (TPT) initiations among persons living with HIV and a high TB treatment success rate among drug-susceptible TB cases. New and relapse TB notifications in children below 15 years increased by 43%, from 2,724 in 2020 to 3,890 in 2021. TB notifications ratio between children aged 0-4 and 5-14 was 0.9, an improvement from what we achieved in 2018 (the ratio was 0.7). The proportion of TB patients who are HIV positive continued to decrease, reaching 34% in 2021 from 39% in 2020. Sustained increases in TB notifications, treatment success rate, and TPT initiations have resulted in a rapid decrease in the TB incidence rate that reached 307 per 100,000 population in 2021 against a rate of 391 in 2015.
more
The current document provides the background, justification and objectives for the revision of WHO policy on LF-LAM. It provides details on the index test (AlereLAM) being assessed. It also describes the process of evidence retrieval, quality assess
...
ment and grading; formulation of the recommendations; and GDG decision-making. Finally, the document presents policy recommendations and related remarks.
more
Asthma is the most common noncommunicable disease in children, and among the most common in adults. According to the most recent estimates from the
...
Global Asthma Network Phase I study, around one in 10 children and adults have symptoms of asthma and one in 20 school-aged children have severe asthma symptoms, with marked variations in prevalence and in prevalence trends between countries and regions of the world. The Global Burden of Disease Study estimated that asthma caused the loss of 21.6 million healthy years of life (disability-adjusted life years) and 461 069 deaths in 2019. Approximately 90% of the asthma burden of disease is borne by people living low and middle income countries (LMICs). Some countries report very high (up to 90%) rates of uncontrolled asthma. While the prevalence of asthma is highest in countries with a high Socio-Demographic Index (SDI), death rates from asthma are highest in countries with low and lower middle incomes.
more
The WHO Guidelines on physical activity and sedentary behaviour provide evidence-based public health recommendations for children, adolescents, adults
...
and older adults on the amount of physical activity (frequency, intensity and duration) required to offer significant health benefits and mitigate health risks. For the first time, recommendations are provided on the associations between sedentary behaviour and health outcomes, as well as for subpopulations, such as pregnant and postpartum women, and people living with chronic conditions or disability.
more
The family-centered approach to reaching every child living with HIV. This report examines the structural barriers impeding equitable access to
...
HIV testing, treatment initiation and long-term adherence – essential elements for sustaining health and well-being for children, adolescents and young women. Rooted in socio-cultural norms, gender disparities and systemic inequalities, these barriers obstruct progress by perpetuating stigma, limiting healthcare access and destabilizing treatment continuity, stalling efforts toward the 10-10-106 and 95-95-957 targets.
more
Helping Children Live with HIV offers a holistic approach by building on the existing knowledge of parents
...
and caregivers and respecting the importance of other local resources. It integrates health care, illness prevention, and psychosocial support for children and families coping with poverty, food insecurity, emotional trauma, loss, as well as stigma and discrimination.
This guide is intended for broad use by parents, family members, and health workers in home settings and throughout community-based health programs.
To learn more, view the table of contents and a sample chapter, and to buy your copy of this essential new resource from Hesperian.
more
6th edition. The HIV epidemic Namibia is gradually being brouhgt under countrol as demonstrated by results in the preliminary report of Namibia Population-Based HIV Impact Assessment (NAMPHIA), a cr
...
oss-sectional household-based survey that was conducted in 2017. Currently, it is estimated that about 204,207 Namibians are living with HIV. According to the NAMPHIA preliminary report, HIV prevalence among adults aged 15-64 is 12.6% and the annual HIV incidence is 0.36%. This report, together with HIV programmatic data has show that Namibia is one of the few African countries to meet the 2015 Joint United Nations Program on HIV and epidemic globally by 2030.
more
This guide presents new knowledge and guidelines on the provision of care to persons living with HIV
...
/AIDS, in accordance with the last guidelines of the World Health Organization (WHO) published in 2006 and adapted to the Rwandan national context. It thus responds to the need by the Ministry of Health to improve the skills of the actors in the health sector as well as the quality of care and antiretroviral treatment offered in both public and private health facilities countrywide.
more
This training seeks to equip health workers who have contact with children in HIV settings with
...
the knowledge and skills to better integrate violence against children (VAC) services into their work. It seeks to transmit information and skills to make them: feel comfortable talking with, providing services and making appropriate referrals to children and their caregivers who are at risk of or experiencing violence.
This three-day training package includes ten modules to be delivered to groups of 25-30 health workers. The training is aimed at different cadres of health workers, including: nurses and midwives; clinicians; HIV counselors; medical social workers; pharmacists; community health workers, and others who are involved in children’s health care in health settings
more
Updated recommendations on treatment of adolescents and children with chronic HCV infection
recommended
The new treatment recommendations that extend the 2018 treat all recommendation for adults with chronic HCV infection to include adolescents and
...
children down to 3 years, and to align the existing recommended pangenotypic direct-acting antiviral (DAA) regimens (SOF/DCV, SOF/VEL and G/P) for adults, to those for adolescents and children. This alignment is expected to simplify procurement, promote access to treatment among children in low- and middle-income countries and contribute to global efforts to eliminate the disease
more
Recent suspensions and reductions in official development assistance (ODA) have posed significant challenges to HIV programme continuity in several countries. These funding disruptions have impacted
...
people living with HIV and other vulnerable populations
who rely on these essential services, like antiretroviral treatment, particularly in settings reliant on external financing . In some cases, governments are stepping in to reestablish services that were previously provided through other sources of funding.
more
2021 UNAIDS Global AIDS Update. UNAIDS report shows that people living with HIV face a double jeopardy,
...
HIV and COVID-19, while key populations and children continue to be left behind in access to HIV services
more
The manual is written for clinicians working at the district hospital (first-level referral care) who diagnose and manage sick adolescents and adults
...
in resource constrained settings. It aims to support clinical reasoning, and to provide an effective clinical approach and protocols for the management of common and serious or potentially life-threatening conditions at district hospitals. The target audience thus includes doctors, clinical officers, health officers, and senior nurse practitioners. It has been designed to be applicable in both high and low HIV prevalence settings.
Volume 2 provides a symptom-based approach to clinical care for acute and subacute conditions (including mental health). It provides short summaries of the management of diseases that affect multiple systems of the body, focusing on communicable diseases. It also includes the chronic or long-term management of HIV, TB, alcohol, and substance use disorders.
more
The Zambia Population Based HIV impact assessment of 2016, reported the prevalence of viral hepatitis in Zambia as ranging between 5.6% among adults aged 15 to 59% in the general population,
...
and 7.1% among HIV infected individuals. It is estimated that the majority of persons with chronic hepatitis B and/ or hepatitis C are unware of their infection and do not benefit from promotive, preventive and curative services designed to reduce onward transmission. Zambia introduced hepatitis B virus vaccine to the routine Under 5 vaccination schedule in 2005. Preliminary results from the ZAMPHIA indicate that hundreds of infections have been abated in children since then. However, its also clear that we continue to miss key opportunities to prevent transmission, diagnose and treat infections, prevent serious disease, and in many cases cure people. In addition, high risk groups inter alia health care workers still have limited access to the vaccine.
more
Currently, there are only two manufacturers with HIV POC diagnostic products prequalified by the World Health
Organization (WHO) and eligible for
...
procurement through the United Nations. UNICEF concluded its last tender for
HIV EID and VL POC diagnostic technologies in 2018 and awarded two manufacturers long-term arrangements
(LTAs) to supply WHO prequalified product
more
Progress report and road map. Countries included in this report: Algeria, Afghanistan, Bahrain, Djibouti, Egypt, the Islamic Republic of Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman, Pakistan, Qatar, State of Palestine, Saudi Arabia, So
...
malia, Sudan, the Syrian Arab Republic, Tunisia, United Arab Emirates, Yemen.
To support countries in the region to achieve triple elimination goals, this report collects and assesses national policies and key indicators on EMTCT efforts against WHO criteria for validation of the EMTCT of HIV, syphilis and HBV. Based on analysis and consultations with national policymakers, the report provides a Road Map for countries at different stages of readiness to follow towards triple elimination goals.
more
The findings of the report are both urgent and devastating. At the current rate of progress, by 2040 we would still have 1.9 million new HIV infections an
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d 990,000 AIDS-related deaths in children. But if funding for HIV prevention and treatment continues to fall as current trends suggest, the world could face an additional 1.1 million new HIV infections and 820,000 additional deaths by 2040. In this worst-case scenario, by 2040, three million children would acquire HIV and nearly 1.8 million would die of AIDS-related causes — the vast majority in sub-Saharan Africa. These are not statistics; they are children with dreams, families, and futures. They represent our shared humanity — and our collective failure if we do not act.
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The evidence base for differentiated care for stable patients has grown in recent years. There has been less attention, however, to developing differentiated models of care for patients with advanced or unstable
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HIV disease. Current clinical guidelines and policies regarding optimal packages of care for high-risk patients give few or no recommendations about how, by whom, or where they should be delivered for optimal impact.
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The duration of breastfeeding and support from health services to improve feeding practices among mothers living with HIV
This operational gui ... dance, developed by WHO, UNICEF and ENN, outlines the duration of breastfeeding and support from health services to improve infant feeding practices among mothers living with HIV. It is intended to be used to complement emergency and sectoral guidelines on health, nutrition and HIV, including specifically infant feeding, prevention of mother-to-child transmission of HIV and paediatric antiretroviral treatment. more
This operational gui ... dance, developed by WHO, UNICEF and ENN, outlines the duration of breastfeeding and support from health services to improve infant feeding practices among mothers living with HIV. It is intended to be used to complement emergency and sectoral guidelines on health, nutrition and HIV, including specifically infant feeding, prevention of mother-to-child transmission of HIV and paediatric antiretroviral treatment. more
