Little progress has been made since the 1960s and 1970s to widen the therapeutic arsenal against Trypanosoma cruzi, the causative pathogen of Chagas disease, which remains a frustrating and perplexing infectious disease. This chapter focuses on the strategic and operational challenges in the clinica...l drug development of a novel antitrypanosomal agent for Chagas disease. The various elements that contribute to a robust assessment of treatment effect including dose selection, choice of patient population, trial methodology, endpoint measures, and regulatory perspectives are discussed. The learnings herein should serve as resource to help researchers and other stakeholders optimize their clinical development plans and speed delivery of new medicines to patients with Chagas disease.
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To meet the need for laboratory diagnosis to be integrated in community care, the new 2022 Update describes point-of-care tests that can be performed both in district laboratories and peripheral healthcare facilities by non-specialist staff. Also included are recently developed self-tests.
For the purposes of presenting the Guide as an e-course it has been divided into five parts. Each part of the course takes 30 to 45 minutes and must be completed in order. You can save and exit at any point throughout the course.
The five quiz sections presented at the end of each part of the cours...e are not part of the Basic Malaria Microscopy Learner’s Guide. They have been created by the Global Health Network to help you test your knowledge of the course and to gain a certificate to demonstrate that you have completed it
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The purpose of this manual is to train health workers to use G6PD rapid diagnostic tests (RDTs) safely and effectively, so as to inform appropriate decision making for P. vivax radical cure. This manual should be used with the accompanying job aid. The job aid is a set of step-by-step instructions a...bout how to use a G6PD RDT. It contains both words and pictures.
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