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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Manual for male circumcision under local anaesthesia and HIV prevention services for adolescent boys and men
recommended

World Health Organization WHO (2018) C_WHO

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Dispelling rumours around Zika and microcephaly

World Health Organization (2016) C_WHO

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Building the legacy of Ebola: Survivors, health systems, and a blueprint for research and development

World Health Organization WHO (2017) C_WHO

This report describes the work done by WHO from January 2015 up to the end of December 2016 to address the long-term issues of survivor care, health-systems strengthening and research.

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Education and Training. Technical Series on Safer Primary Care

World Health Organization WHO (2016) C_WHO

Good primary care may lead to fewer avoidable hospitalizations, but unsafe primary care can cause avoidable illness and injury, leading to unnecessary hospitalizations, and in some cases, disability and even death.Implementing system changes and practices are crucial to improve safety at all levels ... more

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National Strategic Framework for the Elimination of Obstetrics Fistula in Nigeria 2011-2015

Federal Ministry of Health, Nigeria (2012) C1

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India’s Disability Policy – Analysis of Core Concepts of Human Rights

Jessica O’Dowd, Hasheem Mannan, Joanne McVeigh (2013) C1

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India: Guidelines for ASHA based Surveillance for Leprosy Suspects

Directorate General of Health Services, National Leprosy Eradication Programme, Government of India (2017) C1

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NTP management and child TB - Module 9a

International Union Against Tuberculosis and Lung Disease, World Health Organization (2017) C_WHO

Accessed November 2017

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International technical guidance on sexuality education. An evidence-informed approach.

UNESCO (2018) CC

This revised and fully updated edition of the International technical guidance on sexuality education benefits from a new review of the current evidence, and reaffirms the position of sexuality education within a framework of human rights and gender equality. It promotes structured learning about... more

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WHO technical consultation on oxygen access scale-up for COVID-19

World Health Organization WHO (2021) C_WHO

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Save the Children's COVID-19 Program Framework and Guidance and Companion Pieces

Save the Children (2020) C1

How we respond both now and going forward will help mitigate the impact of COVID-19, and to the extent possible preserve children’s rights to Survive, Learn, and Be Protected. We will focus our efforts on the most critical work essential to maintaining these commitments to the extent possible.

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Model disability survey (MDS): survey manual

World Health Organization (WHO) & The World Bank (WB) WHO (2017) CC

The World Health Organization's Model Disability Survey (MDS) Manual is a tool to help implement the MDS in countries and to improve the quality of the interview process. This manual is intended to provide practical information about the survey instruments and their use during interviews. This manua... more

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CONSENSUS DOCUMENT FOR MANAGEMENT OF GASTRIC CANCER

Indian Council of Medical Research (ICMR) (2014) C1

Full document available: https://www.icmr.nic.in/sites/default/files/guidelines/Gastric%20Cancer%20Final%20pdf%20for%20farrow_0.pdf | Prepared as an outcome of ICMR Subcommittee on Gastric Cancer | Coordinated by Division of Non Communicable Diseases | This Consensus Document on Management of Gastri... more

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WHAT MATTERS? Humanitarian Feedback Bulletin on Rohingya Response Issue 19 × Wednesday, February 06, 2019

International Organization for Migration, Internews Network, BBC Media Action, Translators without Borders International Organization for Migration, Internews Network, BBC Media Action, Translators without Borders (2019) C1

Source: 1,981 listener groups, engaging 9,281 individuals, conducted by IOM, Bangladesh Betar and ACF from August to November 2018. This feedback was collected from camps 1, 2, 10, 11, 15, 16, 19, 22, 23, 24 and 25. Listener groups included an even spread of men, women, adults and children and ar... more

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Methamphetamine continues to dominate synthetic drug markets

United Nations Office on Drugs and Crime; Global smart (2018) C2

Volume 20, September Global smart update

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Guidelines on second-and third-line medicines and type of insulin for the control of blood glucose levels in non-pregnant adults with diabetes mellitus

World Health Organization WHO (2018) C_WHO

The new guidelines provide public health guidance on pharmacological agents for managing hyperglycaemia in type 1 and type 2 diabetes for use in primary health-care in low-resource settings. These guidelines update the recommendations for managing hyperglycaemia in the WHO Package of Essential NCD I... more

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J12. Wellbeing: identification and prevention of burnout, depression and suicide among child mental health clinicians

Frances Javier, Julie Chilton & Andrés Martin IACAPAP (2015) C1

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Technical note for Ebola virus disease preparedness planning for entry screening at airports, ports and land crossings

World Health Organization (2014)

Manual for male circumcision under local anaesthesia and HIV prevention services for adolescent boys and men recommended

Manual for male circumcision under local anaesthesia and HIV prevention services for adolescent boys and men
recommended