Arsenical monotherapies were previously very successful for treating human African trypanosomiasis (HAT).
Melarsoprol resistance emerged as early as the 1970s and was widespread by the late 1990s.
Melarsoprol resistance represents the only example of widespread drug resistance in HAT patients wher...e the genetic mechanism has been established.
The current goal of elimination of HAT as a public health problem by 2020 may be undermined by the emergence and spread of resistance to current or new drugs.
Insights into potential resistance mechanisms for current and new drugs will facilitate predictions of the likelihood of resistance and will also facilitate rational approaches to minimizing, monitoring, and tackling the future emergence of resistance.
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Background paper 8
The Independent Panel for Pandemic Preparedness and Response
May 2021
Meeting report, 25-26 September 2017 Copenhagen, Denmark
This third booklet of the World Drug Report 2022 has a dual focus: opioids and cannabis.
The first chapter of the booklet provides an overview of opioids as a group of substances and their patterns of non-medical use at the global level. It also reviews the latest trends in the global supply of opi...ates and synthetic opioids and the availability of pharmaceutical opioids for medical consumption. Issues specific to regional patterns and trends in opioid markets are also analysed, including the opioid crisis in North America and in Africa and the Middle East. The chapter also includes a discussion of the potential impact, in the region and worldwide, of changes in opium poppy cultivation and opium production in Afghanistan. reireg
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This document briefly describes the macroeconomic performance before the spread of the coronavirus (COVID-19), which is mainly characterized by severe economic depression, economic and financial sanctions by the Trump administration, and tight fiscal space that constrains to undertake additional mea...sures. It estimates three economic scenarios based on different oil price assumptions for 2020. The negative effects of the quarantine on the economy are estimated using the two biggest shocks faced by Venezuela in its recent history. It emphasizes the relevance of foreign currency and external financing to mitigate the pandemic’s impact. Finally, this paper discusses the economic measures taken by the government.
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The document presents an assessment developed by both institutions as a contribution to the prioritization of education in national response plans to the health emergency and future recovery strategies. "Countries have deployed various response and recovery plans in which education needs to be incor...porated as a central element," the report says, "not only to ensure an education response, but to achieve an equitable, inclusive and sustainable recovery”.
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Chaque année, des milliers d’enfants béninois meurent ou n’arrivent pas à développer pleinement leur potentiel physique ou intellectuel du fait de la malnutrition chronique. La présente politique du secteur de la santé pour la nutrition se focalise sur la mère, lenourrisson,... l’enfant et l’adolescent et prend en compte les résolutions du récent forum national organisé à Cotonoudu 11 au 13 juin 2015, par le Conseil National de l’Alimentation et de la Nutrition(CAN)sur la lutte contre la malnutrition chronique axée sur la fenêtre d’opportunité des 1000 premiers jours de la vie (allant de la conception à la fin de la deuxième année de vie). Elle se fonde sur les principes d’équité?d’éthique et de transparence dans la gestion des problèmes nutritionnels.Cette politique est l’œuvre de la Direction de la Santé de la Mère et de l’Enfant (DSME) avec le soutien technique et financier de l’Organisation Mondiale de la Santé (OMS). Elle servira au cours des dix prochaines années (2016-2025) d’orientation à tous les acteurset partenaires qui contribuent à l’amélioration de l’état nutritionnel des cibles visées.
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Carta Enciclica Fratelli Tutti sobre la fraternidad y la amistad social
Este documento tiene como finalidad presentar un análisis de la situación de protección en Colombia a nivel nacional. El documento resalta los principales riesgos de protección y la rápida evolución de la vulneración de derechos humanos a la que se enfrenta la población colombiana y la pobla...ción refugiada y migrante presente en el territorio, en el marco del conflicto armado interno, desastres y Covid-19. Tras el análisis, se sugieren recomendaciones para abordar la crisis de protección que se evidencia en el país.
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Le rapport 2020 sur la situation du personnel infirmier dans le monde : investir dans la formation, l’emploi et le leadership est publié alors que le monde assiste à un engagement politique sans précédent en faveur de la couverture sanitaire universelle. Parallèlement, notre capacité de pré...paration et de riposte d’urgence est mise à rude épreuve par la flambée actuelle de COVID-19 et les déplacements massifs de population dus aux conflits. Les infirmières et les infirmiers assurent des soins indispensables dans chacune de ces circonstances. Aujourd’hui plus que jamais, le monde a besoin qu’ils mettent pleinement à profit leurs qualifications et leur formation.
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Guía de tratamiento farmacológico y manejo deescenarios clínicos de casos de COVID-19 – enero 2022 Guía de tratamiento farmacológico y manejo deLeer más
Anaesthesia Tutorial of the Week
Usage Guidelines
Junior and Senior Secondary
Are we ready to face the flood?
This book contains general knowledge about the flood, the efforts made before, during, and after the flood and what things can be done by children and adolescents while in evacuation. This book is done specifically for school children in Indonesia
Clinical care for severe acute respiratory infection: toolkit: COVID-19 adaptation