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Therapeutics and COVID-19 (Living Guideline, 10 November 2023)

World Health Organization WHO (2023) C_WHO

WHO has updated its guidelines for COVID-19 therapeutics, with revised recommendations for patients with non-severe COVID-19. This is the 13th update to these guidelines. Updated risk rates for hospital admission in patients with non-severe COVID-19 The guidance includes updated risk rates for... hospital admission in patients with non-severe COVID-19. The current COVID-19 virus variants tend to cause less severe disease while immunity levels are higher due to vaccination, leading to lower risks of severe illness and death for most patients. This update includes new baseline risk estimates for hospital admission in patients with non-severe COVID-19. The new ‘moderate risk’ category now includes people previously considered to be high risk including older people and/or those with chronic conditions, disabilities, and comorbidities of chronic disease. The updated risk estimates will assist healthcare professionals to identify individuals at high, moderate or low risk of hospital admission, and to tailor treatment according to WHO guidelines: **High: **People who are immunosuppressed remain at higher risk if they contract COVID-19, with an estimated hospitalization rate of 6%. **Moderate: **People over 65 years old, those with conditions like obesity, diabetes and/or chronic conditions including chronic obstructive pulmonary disease, kidney or liver disease, cancer, people with disabilities and those with comorbidities of chronic disease are at moderate risk, with an estimated hospitalization rate of 3%. Low: Those who are not in the high or moderate risk categories are at low risk of hospitalization (0.5%). Most people are low risk. Review of COVID-19 treatments for people with non-severe COVID-19 WHO continues to strongly recommend nirmatrelvir-ritonavir (also known by its brand name ‘Paxlovid’) for people at high-risk and moderate risk of hospitalization. The recommendations state that nirmatrelvir-ritonavir is considered the best choice for most eligible patients, given its therapeutic benefits, ease of administration and fewer concerns about potential harms. Nirmatrelvir-ritonavir was first recommended by WHO in April 2022. If nirmatrelvir-ritonavir is not available to patients at high-risk of hospitalization, WHO suggests the use of molnupiravir or remdesivir instead. WHO suggests against the use of molnupiravir and remdesivir for patients at moderate risk, judging the potential harms to outweigh the limited benefits in patients at moderate risk of hospital admission. For people at low risk of hospitalization, WHO does not recommend any antiviral therapy. Symptoms like fever and pain can continue to be managed with analgesics like paracetamol. WHO also recommends against use of a new antiviral (VV116) for patients, except in clinical trials. The update also includes a strong recommendation against the use of ivermectin for patients with non-severe COVID-19. WHO continues to advise that in patients with severe or critical COVID-19, ivermectin should only be used in clinical trials. more

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Ending Aids - Progress towards the 90-90-90 targets

UNAIDS (2017) C2

Global AIDS Update 2017

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Communities at the Centre

UNAIDS (2019) C2

Defending Rights Breaking Barriers Reaching People with HIV Services Global Aids Update 2019

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Preschool PTSD Treatment

Scheeringa, M.S., Amaya-Jackson, L. & Cohen, J. (2010) C2

Version 1.7 Updated October 14, 2010 | Preschool PTSD Treatment (PPT) is a theory-driven, manualized protocol based on cognitive-behavioral therapy (CBT) with modifications for young children. Some of these modifications involve parent-child relationship dynamics that are salient for this age grou... more

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Young people in HIV care in Ukraine: a national survey on characteristics and service provision (version 1; peer review: 2 approved)

G. Kyselyova; V. Martsynovska; A. Volokha; H. Bailey et al. F1000Research (2019) C2

F1000Research 2019, 8:323 Last updated: 17 MAY 2019

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District Health Management Information System (DHMIS) - Standard Operating Procedures Facility Level

Health Republic of South Africa (2016) CC

This document provides SOPS to ensure appropriate data and information management at health facilities. These SOPs are an updated version of the 2013 SOPs. These SOPs aim to clarify the responsibilities and procedures for effective management of aggregated routine health service data

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The BACPR Standards and Core Components for Cardiovascular Disease Prevention and Rehabilitation 2017

British Association for Cardiovascular Prevention and Rehabilitation (2017) CC

This is an update (third edition) of the BACPR Standards & Core Components and represents current evidence-based best practice and a pragmatic overview of the structure and function of Cardiovascular Prevention and Rehabilitation Programmes (CPRPs) in the UK. The previously described seven standards... more

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Recommendations for management of common childhood conditions
recommended

World Health Organization (2012)

Evidence for technical update of pocket book recommendations. Newborn conditions, dysentery, pneumonia, oxygen use and delivery, common causes of fever, severe acute malnutrition and supportive care

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Ebola research and development landscape of clinical candidates and trials

World Health Organization (WHO) (2015) C_WHO

The report presents current information (updated to September 2015) on candidate vaccines, therapies and medical devices for Ebola and gives an overview of completed and on-going trials.

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Global guidelines on the prevention of surgical site infection. 2nd edition
recommended

World Health Organization WHO (2018) C_WHO

These WHO guidelines which were updated in 2018, are valid for any country and suitable to local adaptations, and take account of the strength of available scientific evidence, the cost and resource implications, and patient values and preferences. The 2018 edition of the guidelines includes the re... more

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International technical guidance on sexuality education. An evidence-informed approach.

UNESCO (2018) CC

This revised and fully updated edition of the International technical guidance on sexuality education benefits from a new review of the current evidence, and reaffirms the position of sexuality education within a framework of human rights and gender equality. It promotes structured learning about... more

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Operational guidance on the use of yellow fever assays in the context of surveillance

World Health Organization WHO (2023) C_WHO

This publication aims to provide updated guidance on the specific use of yellow fever laboratory assays in the context of surveillance to be used across the Global Yellow Fever Laboratory Network for disease surveillance. In the recent years, new commercial assays became available and are now recomm... more

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Handbook for public health capacity-building at ground crossings and cross-border collaboration

World Health Organization WHO (2020) C_WHO

This handbook follows a comprehensive approach to health system strengthening at borders in order to support IHR national focal points and other national agencies in developing and implementing evidence-based action plans for IHR capacity development at ground crossings. The approach includes the mo... more

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Infant and young child feeding: counselling cards for health workers
recommended

World Health Organization WHO; UNICEF (2021) C_WHO

This set of Counselling cards has been adapted from the Community infant and young child feeding counselling package and form part of the updated training course. They were developed for course participants and depict key infant and young child feeding concepts and behaviours for health workers to s... more

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Guidelines for laboratory and field testing of molluscicides for control of schistosomiasis

World Health Organization WHO (2019) C_WHO

This document provides up-to-date guidance on laboratory studies as well as smallscale (semi-field) and large-scale field trials to assess the efficacy and determine field application rates of new molluscicide products for control of schistosomiasis.

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Suicide Mortality in the Americas. Regional Report 2015-2019

PAHO WHO PAHO (2021) C_WHO

This report provides updated data on suicide in the Region of the Americas and is issued every five years, this being the fourth edition. In addition to including analysis similar to previous reports (suicide according to age, sex, as well as methods used), this report includes an expanded set of an... more

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Parenting programs

D. Haslam; A. Mejia; M. R. Sanders; P. J. de Vries IACAPAP (2016) C2

The importance of growing up in a nurturing and supportive family environment cannot be underestimated. Raising children in a warm, loving environment sets them on a positive developmental trajectory for later life success (Biglan et al, 2012). Conversely, children raised in homes with inconsistent ... more

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Background Paper 6.11 Alzheimer Disease and other Dementias

B. Duthey, Ph.D; S. Tanna (2004) C2

20 February 2013 Update on 2004 Background Paper (Written by Saloni Tanna) Priority Medicines for Europe and the World "A Public Health Approach to Innovation"

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Consolidated strategic information guidelines for HIV in the health sector

World Health Organization (2020) C_WHO

These guidelines – an update to the World Health Organization’s 2015 publication Consolidated strategic information guidelines – present a set of essential aggregate indicators and guidance on choosing, collecting and systematically analysing strategic information to manage and monitor the nat... more

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Uganda Clinical Guidelines. National Guidelines on Management of Common Conditions
recommended

Ministry of Health, Uganda (2016) C1

This new edition and fully updated publication replaces the 2012 UCG and is being circulated free of charge to all public and private sector prescribers, pharmacists, and regulatory authorities in the country

Recommendations for management of common childhood conditions recommended

Global guidelines on the prevention of surgical site infection. 2nd edition recommended

Infant and young child feeding: counselling cards for health workers recommended

Uganda Clinical Guidelines. National Guidelines on Management of Common Conditions recommended

Recommendations for management of common childhood conditions
recommended

Global guidelines on the prevention of surgical site infection. 2nd edition
recommended

Infant and young child feeding: counselling cards for health workers
recommended

Uganda Clinical Guidelines. National Guidelines on Management of Common Conditions
recommended