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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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COVID-19 and Food Safety: Guidance for Food Businesses

World Health Organization WHO (2020) C_WHO

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Module: Other significant mental health complaints

WHO WHO (2015) C_WHO

Overview Learning objectives • Promote respect and dignity for people with other significant mental health complaints. • Know the common presentation of other significant mental health complaints. • Know the assessment principles of other significant mental health complaints. • Know the... more

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COVID-19 Vaccine Roll Outs in ASEAN & Asia – Live Updates by Country

Asean Briefing (2021) CC

It will be updated continuously. Details of COVID-19 availability in all ten ASEAN countries and another 30 Asian nations. Due to the developing situation in China and Asia concerning the Coronavirus, we will be operating this article as a running live update service to keep businesses involved in... more

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HIV and TB in Practice for nurses: Starting ART for treatment and prevention in people with active TB and HIV

Theo Smart (2012) C1

HIV & AIDS Treatment in Practice No.199

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Invisible Wounds. The impact of six years of war on the mental health of Syria’s children

Save the Children (2017) C1

“The children are psychologically crushed and tired. When we do activities like singing with them, they don’t respond at all. They don’t laugh like they would normally. They draw images of children being butchered in the war, or tanks, or the siege and the lack of food.” Teacher in the... more

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Training Course on the Management of Severe Malnutrition Support Materials for Facilitators

WHO WHO (2002)

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Protection, Participation and Potential: Women and Girls in Yemen’s War

International Rescue Committee (2019) C1

Women and girls are paying the price of the war in Yemen – Humanitarian actors must increase the priority given to women and girls’ needs, with specific attention to GBV prevention and response, and reproductive health services

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Malawi Guidelines for Clinical Management of HIV in Children and Adults

Ministry of Health, Malawi (2016) C1

This document is written for medical doctors, clinical officers, medical assistants, nurses, midwives, health surveillance assistants (HSAs), and medical records clerks who are working in public and private sector health facilities in Malawi. It is designed to be a practical guide for implementation... more

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First Aid

Werner, D, et al. Hesperian (2013)

Where there is no doctor Chapter 3

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“A time of fear”: local, national, and international responses to a large Ebola outbreak in Uganda

John Kinsman (2012) CC

Globalization and Health 2012, 8:15

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SAM2020: An agenda for scaling-up the management of Severe Acute Malnutrition by 2020

Action Against Hunger (2015) C1

The agenda focuses on six critical changes necessary for more children suffering from SAM to access effective treatment. Building on lessons from the last decade, and the experiences of other successful health initiatives, the agenda addresses issues ranging from the creation of a more enabling envi... more

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Pocket Guide for Peer Education Program to Reduce TB and HIV Risks in Tanzania Prisons

B. Mboya, P. Maro, J. Gulaka et al. Ministry of Health, Tanzania; AIDSFree (2017) C1

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Bipolar Disorder

National Institute for Health and Care Excellence (NICE) (2016) CC

Mental Health Information

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Iraq: Coronavirus Disease 2021 (COVID-19) - Weekly Situation Report (Week 31) (2 – 8 Aug 2021)

Office for the Coordination of Humanitarian Affairs OCHA (2021) C2

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Prevention and control of noncommunicable diseases in Turkey - The case for investment

Kontsevaya A, Farrington J, Balcılar M, Ergüder T World Health Organization (2018) C_WHO

Noncommunicable diseases (NCDs) such as cancer, cardiovascular diseases, diabetes and chronic respiratory diseases and their risk factors are an increasing public health and development challenge in Turkey. This report provides evidence through three analyses that NCDs reduce economic output, and di... more

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Safety surveillance of COVID-19 vaccines in pregnant and breastfeeding women

World Health Organization WHO (2021) C_WHO

COVID-19 Vaccines: 1 Safety Surveillance 2 Manual While there is no indication that pregnant women have an increased susceptibility to infection with SARS-CoV-2, there is evidence that pregnancy may increase the risk of severe illness and mortality from COVID-19 disease in comparison with non-pregn... more

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Transforming Agriculture in Southern Africa

Sikora, R.A.; et al. Routledge (2020) CC

Constraints, Technologies, Policies and Processes

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Multi-Sector Nutrition Education and Communication Strategy (NECS) II 2021-2025

Government of Malawi; Department of Nutrition; HIV and AIDS Ministry of Health (2021) CC2

The Department of Nutrition, HIV and AIDS (DNHA) in Ministry of Health and Population is grateful to all stakeholders who contributed to the development of the Nutrition Education Communication Strategy II. The DNHA acknowledges the financial and technical support from the World Bank and USAID throu... more

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Pharmacy & Poison Act Kenya

Ministry of Health, Kenya; Pharmacy and Poisons Board (2019) CC