Arsenical monotherapies were previously very successful for treating human African trypanosomiasis (HAT).
Melarsoprol resistance emerged as early as the 1970s and was widespread by the late 1990s.
Melarsoprol resistance represents the only example of widespread drug resistance in HAT patients wher...e the genetic mechanism has been established.
The current goal of elimination of HAT as a public health problem by 2020 may be undermined by the emergence and spread of resistance to current or new drugs.
Insights into potential resistance mechanisms for current and new drugs will facilitate predictions of the likelihood of resistance and will also facilitate rational approaches to minimizing, monitoring, and tackling the future emergence of resistance.
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Burden of T. solium: Neurocysticercosis is a disease induced by T. solium larvae penetrating human tissues, especially the nervous system. Neurocysticercosis burdens economies, societies and individuals because of the impact of epilepsy on wages, health costs and social stigmatization of sufferers. ...Health systems are also burdened as treatments must be tailored to individual needs.
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The guidance in this publication consists of generic definitions and methodologies for the characterization of extreme weather and climate events. This publication contribute to ensuring consistent exchange of information that underpins the WMO State of the Climate Reports, Climate Watches, climate ...change studies and other emerging applications.
The purpose of the present guidelines is not to change the practice at the national level. Instead, it provides guidance for generic definitions, which are useful in contributing to WMO State of the Climate reports, climate watches, climate change studies and other emerging applications, including the recently adopted methodology for cataloguing hazardous events (WMO-CHE). These applications require regional and/or international exchange of information on extreme events.
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Global progress against cardiovascular disease (CVD) is flatlining.
Though rates of CVD deaths globally have fallen in the last three
decades, this trend has begun to stall and, without concerted
efforts, is at risk of reversing.
The social protection landscape for people affected by TB in the WHO South-East Asia Region
This guideline provides global, evidence-informed recommendations on daily iron supplementation in infants and children, as a public-health intervention for the prevention of anaemia and iron deficiency. It includes recommendations for iron supplementation in countries where malaria is prevalent.
Ce glossaire actualisé sur le paludisme vise à améliorer la communication et la compréhension mutuelle au sein de la communauté scientifique, ainsi qu'avec les organismes de financement, les responsables de la santé publique chargés des programmes de lutte contre le paludisme et les décideur...s des pays où le paludisme est endémique.
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AWMF guideline, seit 5 Jahren nicht mehr aktualisiert, wird gerade überarbeitet
Overcoming Barriers to TB Control
Training Curriculum
August 2011
UNAIDS/WHO 2015 | Reference
Dracunculiasis (Guinea worm disease), caused by the parasite Dracunculus medinensis, is traditionally acquired by drinking water containing copepods (water fleas) infected with D. medinensis larvae, but in recent years also appears increasingly to be transmitted by eating fish or other aquatic anima...ls. The worm typically emerges through the skin on a lower limb of the host 1 year after infection, causing pain and disability.
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Background paper 8
The Independent Panel for Pandemic Preparedness and Response
May 2021
Environmental pollution, protection, quality and sustainability
Kassa BMC Infectious Diseases (2018) 18:216 https://doi.org/10.1186/s12879-018-3126-5
Second Edition
AIDS Medicines and diagnostics services
July 2015