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EPI 4: Antiepileptic medications for adults and children with HIV

World Health Organization WHO (2015) C_WHO
Scoping Question: For adults and children living with HIV, which antiepileptic medications (such as phenobarbital, phenytoin, carbamazepine or valproic acid) produce benefits and/or harms when compared to a placebo or controls?
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Access to essential respiratory medications remains elusive in LMICs

Karmali, D.; Siddharthan, T. (2022) CC
Over 90% of the morbidity and mortality related to chronic obstructive pulmonary disease (COPD) and asthma occurs in low-income and middle-income countries (LMICs) due to well documented factors including decreased access to screening, trained health professionals, and therapies for disease manageme... more
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Bipolar Disorder. Parents’ Medication Guide for Bipolar Disorder in Children & Adolescents

American Academy of Child and Adolescent Psychiatry (2010) CC
This guide was developed by AACAP to give reliable information about medication used to treat bipolar disorder in children and adolescents to parents whose children have been diagnosed with the illness.
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2014-2015 PTSD Medication Guidelines for Children and Adolescents: Guideline Document

University of South Florida (USF) medicaidmentalhealth.org (2014) C2
Post-Traumatic Stress Disorder (PTSD) in Children under Age 6 | Post-Traumatic Stress Disorder (PTSD) in Children and Adolescents Ages 6 to 17 Years Old
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Role of depot antipsychotic medication in long-term antipsychotic treatment

World Health Organization WHO (2015) C_WHO
Q5.SCOPING QUESTION: In individuals with psychotic disorders (including schizophrenia) who require long-term antipsychotic treatment, what is the safety and role of depot antipsychotic medication?
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Access to Medications for Cardiovascular Diseases in Low- and Middle-Income Countries

Wirtz, V.J.; Kaplan, W.A.; Kwan, G.F. Circulation (2016) CC
Cardiovascular diseases (CVD) represent the highest burden of disease globally. Medicines are a critical intervention used to prevent and treat CVD. This review describes access to medication for CVD from a health system perspective and strategies that have been used to promote access, including pro... more
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The Use of Medication in Treating Childhood and Adolescent Depression: Information for Patients and Familie

American Psychiatric Association; American Academy of Child and Adolescent Psychiatry (2019) C2
Accessed January 22, 2019. This updated version include important research that has added to our knowledge about effective treatments for child and adolescent depression. Its goal is to help parents and families make informed decisions about getting the best care for a child with depression. For ... more
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Rational Use of Inhaled Medications for the Patient with COPD and Multiple Comorbid Conditions: Guidance for Primary Care

Tisiligianni, I.; Hoines, K.; Jensen, C.; et al. International Primary Care Respiratory Group (IPCRG) (2019) CC2
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EPI 3: Anti-epileptic medications for management of established status epilepticus [Updated 2015]

mhGAP; WHO (2015) C_WHO
SCOPING QUESTION: In adults with established status epilepticus (i.e., seizures persisting after the first-line treatment with benzodiazepines [or benzodiazepines-resistant status epilepticus]), which anti-epileptic medications are associated with cessation of seizures and reduced adverse effects)? ... more
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Second-generation antipsychotic medications for psychotic disorders (including schizophrenia)
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World Health Organization WHO (2012) C_WHO
Q14. SCOPING QUESTION: In adults with psychotic disorders (including schizophrenia), what is the comparative effectiveness and safety of second-generation antipsychotic medications?
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National Essential Medicines List - Tertiary/Quaternary Medication Review Process

Republic of South Africa (2017) CC
Long Acting Muscarinic Antagonists (LAMA) such as tiotropium and glycopyrronium are used in the management of COPD1. They have been shown to improve lung function, quality of life and exercise tolerance. They have also been associated with reduced COPD-related exacerbations, associated hospitalisati... more
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Barriers to Access: Medication-Assisted Treatment and Injection-Driven HIV Epidemics

Open Society Institute - Public Health Program; International Harm Reduction Development Program (IHRD) (2019) C2
Public Health Factsheet Accessed: 29.09.2019
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Role of anticholinergic medications in patients requiring long-term antipsychotic treatment for psychotic disorders

World Health Organization WHO (2012) C_WHO
Q6: In individuals with psychotic disorders (including schizophrenia) who require long term antipsychotic treatment, are anticholinergic medications more effective in preventing or reducing extrapyramidal side-effects and/or improving treatment adherence than placebo/treatment as usual?
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National Training Package on Paediatric HIV and AIDS Care and Treatment. Participants Handbook. Module 5: Adherence to Medication for Children and Adolescents

Ministry of Health and Social Welfare, National AIDS Control Programme, Tanzania (2015) C1
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Nueva presentación de la medicación para el tratamiento de la tuberculosis

Ministerio de Salud, Argentina (2014) CC
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Supervised dosing with a long acting opioid medication for the management of prescription opioid dependence (New 2015)

mhGAP; WHO (2015) C_WHO
SCOPING QUESTION: In the management of prescription opioid dependence, does supervised dosing with a long-acting opioid medication result in less opioid use and related harms than non-prescription, detoxification or usual care?
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EPI 2: First-line anti-epileptic medication for management of acute convulsive seizures, when intravenous access is available [2015]

mhGAP; WHO (2015) C_WHO
SCOPING QUESTION: In adults with acute convulsive seizures, where intravenous access is available, which first-line anti- epileptic medication should be used to abort seizures when compared to comparator?
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EPI 5: Anti-epileptic medicines for medication resistant convulsive epilepsy. [New 2015]

mhGAP; WHO (2015) C_WHO
SCOPING QUESTION: For adults and children with medication-resistant convulsive epilepsy, which anti-epileptic medications produce benefits and/or harm in the specified outcomes when compared to a placebo or a comparator?
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Combination of two or more antipsychotic medications for psychotic disorders

World Health Organization WHO (2012) C_WHO
Q2: In individuals with psychotic disorders (including schizophrenia), is the use of two or more antipsychotic medications concurrently more effective and safer than the use of one antipsychotic only?
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Community health workers to improve adherence to anti-seizure medication in rural South Africa: Is it cost-effective?
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Wagner, R.C.; F. Norström, M. Y. Bertram et al. Epilepsia (2020) C1
Low- and middle-income countries (LMICs) experience a high disease burden for epilepsy, a chronic neurological condition.The authors evaluate the cost-effectiveness of community health workers (CHWs) to improve adherence to medication for epilepsy in South Africa. They found that utilizing CHWs to i... more