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Rethinking the Top-Down Approach to Schistosomiasis Control and Elimination in Sub-Saharan Africa

Onasanya A. et al. (2021) CC

The control and elimination of schistosomiasis have over the last two decades involved several strategies, with the current strategy by the World Health Organization (WHO) focusing mainly on treatment with praziquantel during mass drug administration (MDA). However, the disease context is complex wi... more

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African regional progress and status of the programme to eliminate lymphatic filariasis: 2000–2020

Deribe K., Bakajikaa D. K., Zourea H. MG. et al The royal society of tropical medicine and hygiene (2021) C2

To eliminate lymphatic filariasis (LF) by 2020, the World Health Organization (WHO) has launched a campaign against the disease. Since the launch in 2000, significant progress has been made to achieve this ambitious goal. In this article we review the progress and status of the LF programme in Afric... more

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The global distribution of lymphatic filariasis, 2000–2018: a geospatial analysis

The Lancet Global Health (2020) C1

Lymphatic filariasis is a neglected tropical disease that can cause permanent disability through disruption of the lymphatic system. This disease is caused by parasitic filarial worms that are transmitted by mosquitos. Mass drug administration (MDA) of antihelmintics is recommended by WHO to elimina... more

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Safety in administering medicines for neglected tropical diseases

World Health Organization WHO (2021) C_WHO

This manual summarizes key issues related to the safety of NTD medicines and their administration, with a focus on essential medicines used in mass drug administration (MDA), also called preventive chemotherapy. It can be used as a standalone reference manual, but is intended to be used in conjuncti... more

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Informal consultation on end-game challenges for trachoma elimination

World Health Organization WHO (2022) C_WHO

Since 1996, trachoma has been targeted for elimination as a public health problem worldwide. The active trachoma criterion for national elimination as a public health problem is a TF1–9 < 5%, sustained for at least two years in the absence of antibiotic mass drug administration (MDA), in each form... more

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Fascioliasis animal parasitic disease

Pan American Health Organization PAHO; World Health Organization WHO (2022) C_WHO

Fascioliasis is an animal parasitic disease (in cattle and sheep, but also pigs, donkeys, Llamas and alpacas that can be transmitted to humans. The infection is caught when aquatic or semi-aquatic plants with the larvae of the worm attached to their stem or leaves are ingested raw or poorly cooked. ... more

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Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review

Wright J.E., Werkman M., Dunn J.C. et al Parasites and Vectors (2018) C2

Background: The human helminth infections include ascariasis, trichuriasis, hookworm infections, schistosomiasis, lymphatic filariasis (LF) and onchocerciasis. It is estimated that almost 2 billion people worldwide are infected with helminths. Whilst the WHO treatment guidelines for helminth infecti...ons are mostly aimed at controlling morbidity, there has been a recent shift with some countries moving towards goals of disease elimination through mass drug administration, especially for LF and onchocerciasis. However, as prevalence is driven lower, treating entire populations may no longer be the most efficient or cost-effective strategy. Instead, it may be beneficial to identify individuals or demographic groups who are persistently infected, often termed as being “predisposed” to infection, and target treatment at them. Methods: The authors searched Embase, MEDLINE, Global Health, and Web of Science for all English language, humanbased papers investigating predisposition to helminth infections published up to October 31st, 2017. The varying definitions used to describe predisposition, and the statistical tests used to determine its presence, are summarised. Evidence for predisposition is presented, stratified by helminth species, and risk factors for predisposition to infection are identified and discussed. Results: In total, 43 papers were identified, summarising results from 34 different studies in 23 countries. Consistent evidence of predisposition to infection with certain species of human helminth was identified. Children were regularly found to experience greater predisposition to Ascaris lumbricoides, Schistosoma mansoni and S. haematobium than adults. Females were found to be more predisposed to A. lumbricoides infection than were males. Household clustering of infection was identified for A. lumbricoides, T. trichiura and S. japonicum. Ascaris lumbricoides and T. trichiura also showed evidence of familial predisposition. Whilst strong evidence for predisposition to hookworm infection was identified, findings with regards to which groups were affected were considerably more varied than for other helminth species. Conclusion: This review has found consistent evidence of predisposition to heavy (and light) infection for certain human helminth species. However, further research is needed to identify reasons for the reported differences between demographic groups. Molecular epidemiological methods associated with whole genome sequencing to determine ‘who infects whom’ may shed more light on the factors generating predisposition. more

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Development and Introduction of the Filariasis Test Strip: A New Diagnostic Test for the Global Program to Eliminate Lymphatic Filariasis

Pantelias, A.; King, J.D.; Lammie, P.; Weil, G.J. The American Journal of Tropical Medicine and Hygiene (2022) CC

Lymphatic filariasis (LF) is a parasitic disease that is a major cause of chronic disability in the developing world. According to the 2021–2030 road map for neglected tropical diseases (NTDs) published by the World Health Organization (WHO), the global goal for LF is elimination as a public healt... more

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Progress in the elimination of lymphatic filariasis in the Western Pacific Region: successes and challenges

A. Yajima; Ichimori, K. International Health (2020) C1

The Western Pacific Region is the largest and most diverse region in the world, made up of 37 countries and territories in the Pacific, Oceania and parts of Asia, with a population of more than 1.9 billion people stretching over an area from China and Mongolia in the north to New Zealand in the sout... more

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Progress towards elimination of lymphatic filariasis in the Americas region

G. Fontes, da Rocha, E. M. M.; Carvalho Scholte, R. G.; et al. International Health (2020) C1

In South and Central America, lymphatic ﬁlariasis (LF) is caused by Wuchereria bancrofti, which is transmitted by Culex quinquefasciatus, the only vector species in this region. Of the seven countries considered endemic for LF in the Americas in the last decade, Costa Rica, Suriname and Trinidad a... more

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Global programme to eliminate lymphatic filariasis: progress report 2021

World Health Organization WHO (2021) C_WHO

Lymphatic filariasis (LF) is a preventable neglected tropical disease (NTD) caused by infection with the filarial parasites Wuchereria bancrofti, Brugia malayi or B. timori. Mosquitos in the genera Culex, Anopheles, Mansonia and Aedes transmit the parasites from person to person. Lymphoedema and hyd... more

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Have You Heard of Schistosomiasis? Knowledge, Attitudes and Practices in Nampula Province, Mozambique

(2016)

Schistosomiasis is one of the 17 ‘neglected tropical diseases’ as classified by the World Health Organization. In order to better understand attitudes and practices surrounding schistosomiasis, Malaria Consortium carried out a survey in Nampula province, Mozambique, where the organisation is i... more

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Malaria morbidity and mortality in Ebola-affected countries caused by decreased health-care capacity, and the potential effect of mitigation strategies: a modelling analysis
recommended

Patrick G T Walker, Michael T White, Jamie T Griffin, et al. (2015)

The ongoing Ebola epidemic in parts of West Africa largely overwhelmed health-care systems in 2014, making adequate care for malaria impossible and threatening the gains in malaria control achieved over the past decade. The study suggests that untreated malaria cases as a result of reduced health-ca... more

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Guidance on temporary malaria control measures in Ebola-affected countries

World Health Organization (2014)

Malaria is a prevalent cause of febrile illnesses in areas with high transmission, and its clinical presentation overlaps with initial signs of Ebola disease. For this reason, the effectiveness of the Ebola response in Guinea, Liberia and Sierra Leone can be optimized through the deployment of targe... more

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Guideline for Preventive Chemotherapy for the Control of Taenia solium Taeniasis

Pan American Health Organisation PAHO (2021) C_WHO

The larval stage of the parasite Taenia solium can encyst in the central nervous system causing neurocysticercosis, which is the main cause of acquired epilepsy in the countries in which the parasite is endemic. Endemic areas are those with the presence (or likely presence) of the full life cycle of... more

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Prevalence, infection intensity and geographical distribution of schistosomiasis among pre‑school and school aged children in villages surrounding Lake Nyasa

Deogratias Mazigo, H.; Uisso, C.; Kazyoba, P. et al. Nature Research (2021) CC

The sub-Saharan African region, carries 90% of the over 250 million cases of schistosomiasis occurring worldwide. In this region, after Nigeria, Tanzania is second country having the highest cases of schistosomiasis and approximately 51.5%0 of the Tanzanian population is either exposed or live in ar... more

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Progress towards elimination of lymphatic filariasis in the Eastern Mediterranean Region

R. M. R. Ramzy; Al Kubati, A. S. International Health (2021) C1

Lymphatic filariasis (LF), a neglected tropical disease, is targeted for global elimination as a public health problem. This article reviews the history of LF control and elimination activities in the countries of the World Health Organization's (WHO) Eastern Mediterranean Region (EMR) over the last... more

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Indonesia Demographic and Health Survey 2012: Adolescent Reproductive Health

Statistics Indonesia (Badan Pusat Statistik—BPS), National Population and Family Planning Board (BKKBN), Kementerian Kesehatan (Kemenkes—MOH), and ICF International (2013) C2

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Monitoramento e avaliação epidemiológica da intervenção com tratamentos coletivos: manual para programas nacionais de eliminação da fi lariose.

World Health Organization WHO (2015) C_WHO

Monitoramento efetivo, avaliação epidemiológica e análise subsequente são necessários para atingir o objetivo de interromper a transmissão da FL. Este manual foi elaborado para oferecer aos programas nacionais de eliminação da fi lariose informação de qualidade sobre metodologias e proc... more

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Programme mondial pour l’élimination de la filariose lymphatique: rapport de situation, 2020 - Weekly Epidemiological Record, 2021, vol. 96, 41 [‎full issue]‎

World Health Organization WHO; Institutional research information sharing iris (2021) C_WHO

La filariose lymphatique (FL) est une maladie évitable, incapacitante et défigurante, due à une infestation par des filaires parasites des espèces Wuchereria bancrofti, Brugia malayi et B. timori. On estime que 51,4 millions de personnes sont infectées dans le monde. Le lymphœdème et l’hydr... more

Malaria morbidity and mortality in Ebola-affected countries caused by decreased health-care capacity, and the potential effect of mitigation strategies: a modelling analysis recommended

Malaria morbidity and mortality in Ebola-affected countries caused by decreased health-care capacity, and the potential effect of mitigation strategies: a modelling analysis
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