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2
The Manual for Parasitological Surveillance in Prevention of Reintroduction or Re-establishment of Malaria in Sri Lanka (2019) provides guidelines to health professionals on how to conduct effective
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malaria surveillance to prevent the reintroduction of the disease in Sri Lanka, which was certified malaria-free in 2016.
The manual outlines strategies for active and passive case detection, laboratory diagnosis, case investigation, foci investigation, and follow-up measures. It emphasizes targeted screening of high-risk populations, including travelers and migrant workers, and explains the importance of prompt reporting, accurate parasitological confirmation, and coordination between healthcare levels. The overall goal is to maintain Sri Lanka’s malaria-free status by ensuring early detection and rapid response to any imported or locally suspected malaria cases.
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National Guidelines for Clinical Management of Dengue Syndrome - 4rd Edition
Prof. Dr. A. K. Azad; Prof. Dr. S. Tahamina; Prof. Q. T. Islam; et al.
Government of the People's Republic of Bangladesh DGHS Directorate General of Health Services Ministry of Health and Family Welfare ; World Health Organization (Bangladesh)
(2018)
C2
4th Edition 2018
National Malaria Elimination & Aedes Transmitted Disease Control Program
Disease Control Unit Directorate General of Health Services
Chapter 6 contents
Malaria
Human African trypanosomiasis (sleeping sickness)
American trypanosomiasis (Chagas disease)
Leishmaniases
Intestinal protozoan infections (parasitic diarrhoea)
Flukes
Schistosomiases
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Cestodes
Nematode infections
Filariasis
Onchocerciasis (river blindness)
Loiasis.
Lymphatic filariasis (LF)
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WHO Malaria Toolkit app
recommended
The Global Malaria Programme Toolkit app brings together the content of the latest World malaria report and of the consolidated WHO Guidelines for
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malaria as well as operational manuals and other technical documents – in one easy-to-navigate resource.
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2nd edition. This second edition builds on the experience of more than 10 years of SMC deployment, and reflects changes introduced in the WHO guidelines for malaria, 3 June 2022. The goal of this pu
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blication is to share these best practices to improve SMC implementation, coverage, and monitoring and evaluation. Examples of materials and tools as well as links to resources are included to support managers and health workers in their efforts to conduct successful SMC activities and prevent malaria among vulnerable children.
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This malaria case management training manual was developed by the Federal Ministry of Health (FMOH) of Ethiopia, in collaboration with several national and international partners. Primarily based on WHO gu
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idelines and training materials, as well as the 2022 national malaria guidelines and various technical documents, it aims to provide a standardised, simplified resource for clinical health workers in both the public and private sectors in Ethiopia. The manual aims to provide clinical health workers in both the public and private sectors in Ethiopia with a standardised, simplified resource.
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Accessed June 2025. This document outlines the Ministry of Health's management guidelines for malaria in pregnancy in Uganda. Pregnant women without malar
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ia symptoms receive intermittent preventive treatment in pregnancy (IPTp) using sulfadoxine-pyrimethamine (SP) as directly observed therapy (DOT), starting from the second trimester with monthly doses until delivery, except for HIV-positive mothers on cotrimoxazole.
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The ongoing global pandemic of SARS-CoV-2 (Covid-19) poses unique diagnostic and clinical management challenges in regions where seasonal epidemic-prone diseases are endemic. Diseases such as dengue, malaria, seasonal influenza, leptospirosis, chiku
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ngunya, scrub typhus and bacterial infections often present with febrile syndromes that mimic or co-exist with SARS-CoV-2 infection, complicating diagnosis and treatment. This document provides guidelines for preventing, diagnosing and managing such co-infections. A high level of suspicion is essential during the monsoon and post-monsoon seasons, taking into account region-specific disease prevalence. While the WHO's case definition for SARS-CoV-2 is broad and sensitive, the need for parallel testing for co-infections, in accordance with the protocols of the MoHFW, ICMR, NVBDCP and NCDC, is necessitated by overlapping clinical features. Ensuring the availability of reliable rapid diagnostic kits and applying integrated clinical and laboratory approaches are crucial to improving patient outcomes in the context of concurrent infections.
Accessed on 26/08/2025.
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The “Declaration for Accelerated Malaria Mortality Reduction in Africa” is a statement signed by African health ministers reaffirming their commitment to reducing malaria-related mortality. It p
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ledges strengthened leadership, increased domestic financing for malaria control programs, and the implementation of current technical guidelines. The ministers emphasize the need to invest in data technologies, enhance cross-sector collaboration, and build partnerships for financing, research, and innovation in order to intensify malaria control efforts at both national and subnational levels.
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The document titled "Checklist for Assessing Management of Severe Malaria" is part of the MalariaCare Toolkit. It provides a structured tool for supervisors conducting outreach training and supportive supervision (OTSS) visits in healthcare faciliti
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es. The checklist is designed to evaluate and guide the clinical management of severe malaria cases, including diagnostics, treatment planning, complication management, patient monitoring, and the administration of injectable artesunate. It also includes sections for direct observation of clinical procedures and supervisor feedback to help improve healthcare worker performance and adherence to national treatment guidelines.
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Emergency medicine in Rwanda is underdeveloped. Limited training and infrastructure mean that the country has a high mortality rate from acute conditions such as trauma, malaria and obstetric complications. As Rwanda's disease burden shifts, there i
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s a critical need for standardised emergency care. This Emergency Medicine Clinical Guideline (EMCG) provides essential protocols and principles that are tailored to the Rwandan context. The aim is to improve the delivery of emergency care at district and referral hospitals. It is intended as a practical resource for all healthcare providers involved in the management of undifferentiated emergencies.
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Pregnant travelers face numerous risks, notably increased susceptibility to or severity of multiple infections, including malaria. Because pregnant women residing in areas non-endemic for malaria ar
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e unlikely to have protective immunity, travel to endemic areas poses risk of severe illness and pregnancy complications, such as low birthweight and fetal loss. If travel to malaria-endemic areas cannot be avoided, preventive measures are critical. However, malaria chemoprophylaxis in pregnancy can be challenging, since commonly used regimens have varying levels of safety data and national guidelines differ. Furthermore, although chloroquine and mefloquine have wide acceptance for use in pregnancy, regional malaria resistance and non-pregnancy contraindications limit their use. Mosquito repellents, including N,N-diethyl-m-toluamide (DEET) and permethrin treatment of clothing, are considered safe in pregnancy and important to prevent malaria as well as other arthropod-borne infections such as Zika virus infection. Pregnant travelers at risk for malaria exposure should be advised to seek medical attention immediately if any symptoms of illness, particularly fever, develop.
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Prompt, effective antimalarial treatment, and supportive care can substantially reduce the rate of mortality from severe malaria. However, many children in malaria-endemic countries do not have acce
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ss to health facilities or a qualified health care provider and do not receive the necessary care in a timely fashion. Without rapid detection of danger signs and access to effective treatment, including pre-referral treatment that can be administered in the community level, many of these children with severe malaria die.
In situations where there is no immediate access to a health care facility, WHO recommends the administration of a standard dose of an effective antimalarial medicine as pre-referral treatment before referral to a facility at which complete treatment can be administered.
Rectal artesunate is the WHO-recommended pre-referral intervention in situations where artesunate injection are not feasible for children under the age of 6 years with suspected severe malaria. The intervention reduces the risk of death or permanent disability by up to 50% provided the child is referred to a health facility at which complete treatment can be administered.
This field guide is aimed at supporting the effective deployment of RAS as pre-referral treatment of suspected severe malaria in line with the WHO malaria guidelines.
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WHO has updated it recommendations for 3 key malaria prevention strategies: seasonal malaria chemoprevention (SMC), perennial malaria chemopreventi
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on (PMC – previously known as intermittent preventive treatment in infants, or IPTi) and intermittent preventive treatment of malaria in pregnancy (IPTp). When given to the young children and pregnant women who are most vulnerable to malaria, preventive chemotherapy has been shown to be a safe, effective and cost-effective strategy for reducing the disease burden and saving lives.
The updated recommendations on SMC, PMC and IPTp, published today in the WHO Guidelines for malaria, will support the broader use of chemoprevention among young children at high risk of severe malaria in areas with both seasonal and year-round transmission and promote expanded access to preventive chemotherapy in pregnancy.
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The "Integrated Management of Malaria Training – Health Worker’s Manual" is a practical guide developed by Uganda’s Ministry of Health to train healthcare workers at all levels in the effective diagnosis, treatment, prevention, and management
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of malaria. It aligns with national malaria treatment guidelines and aims to improve the quality of care and reduce malaria-related illness and death. The manual covers key topics such as clinical assessment of fever, use of rapid diagnostic tests (RDTs), case management of uncomplicated and severe malaria, malaria in pregnancy, co-infections like HIV, as well as community engagement and proper documentation. It includes structured training sessions, case studies, and job aids designed to strengthen the skills of health workers in both public and private sectors, and to ensure standardized, evidence-based malaria care across the country.
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Malaria and HIV, two of the world’s most deadly diseases, are widespread, but their distribution overlaps greatly in sub-Saharan Africa. Consequently, malaria and HIV coinfection (MHC) is common i
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n the region. In this paper, pertinent publications on the prevalence, impact, and treatment strategies of MHC obtained by searching major electronic databases (PubMed, PubMed Central, Google Scholar, ScienceDirect, and Scopus) were reviewed, and it was found that the prevalence of MHC in SSA was 0.7%–47.5% overall. Prevalence was 0.7%–47.5% in nonpregnant adults, 1.2%–27.8% in children, and 0.94%–37% in pregnant women. MHC was associated with an increased frequency of clinical parasitemia and severe malaria, increased parasite and viral load, and impaired immunity to malaria in nonpregnant adults, children, and pregnant women, increased in placental malaria and related outcomes in pregnant women, and impaired antimalarial drug efficacy in nonpregnant adults and pregnant women. Although a few cases of adverse events have been reported in coinfected patients receiving antimalarial and antiretroviral drugs concurrently, available data are very limited and have not prompted major revision in treatment guidelines for both diseases. Artemisinin-based combination therapy and cotrimoxazole are currently the recommended drugs for treatment and prevention of malaria in HIV-infected children and adults. However, concurrent administration of cotrimoxazole and sulfadoxine–pyrimethamine in HIV-infected pregnant women is not recommended, because of high risk of sulfonamide toxicity. Further research is needed to enhance our understanding of the impact of malaria on HIV, drug–drug interactions in patients receiving antimalarials and antiretroviral drugs concomitantly, and the development of newer, safer, and more cost-effective drugs and vaccines to prevent malaria in HIV-infected pregnant women.
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The Rectal Artesunate Tools & Training package has been developed to support the safe and effective use of artesunate rectal capsules (ARCs) as a pre-referral treatment for severe malaria, in line with WHO
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guidelines. Primarily aimed at community health workers operating in remote areas, the package provides step-by-step visual and written guidance on ARC administration. The training resources were field-tested in Malawi and Senegal, and refined based on user feedback to ensure clarity, usability and cultural appropriateness. The toolkit includes user guides and job aids in English, French and Portuguese, and was created in collaboration with MMV, the WHO, Save the Children, the IFRC, MSF and the Malaria Consortium. These tools form part of broader efforts to integrate ARC into national malaria strategies and strengthen the capacity for an early response in underserved settings.
Accessed on 03/07/2025.
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Antimalarial chemotherapy is crucial for reducing morbidity, mortality, and drug resistance, and is the cornerstone of malaria control. Existing antimalarial drugs act at different stages of the parasite’s life cycle. These drugs range from classi
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c agents such as chloroquine and quinine to newer artemisinin derivatives. They include tissue schizonticides, blood schizonticides, gametocytocides, and sporontocides. Artemisinin and its derivatives are the most effective and fastest-acting treatment against drug-resistant Plasmodium falciparum, achieving rapid parasite clearance and reducing transmission potential. Other key drugs include mefloquine, halofantrine, proguanil, sulfadoxine–pyrimethamine, atovaquone–proguanil, tetracyclines, clindamycin and azithromycin. Each of these drugs has a specific mechanism of action, pharmacokinetics, efficacy, safety profile and contraindications. Rational drug combinations and adherence to national treatment guidelines are essential for managing resistance, ensuring safety in vulnerable populations such as children and pregnant women, and optimising therapeutic outcomes in cases of both uncomplicated and severe malaria.
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Pocket book of hospital care for children
recommended
Guidelines for the Management of common childhood Illness. 2nd edition
These guidelines focus on the management of the major causes of childhood mortality in most developing countries, such as newb
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orn problems, pneumonia, diarrhoea, malaria, meningitis, septicaemia, measles and related conditions, severe acute malnutrition and paediatric HIV/AIDS. It also covers common procedures, patient monitoring and supportive care on the wards and some common surgical conditions that can be managed in small hospitals.
A smart phone and tablet application is available from the Apple or Google Play Store.
Special attention is drawn to the following sections, which are particulary relevant within the COVID-19 context:
Chapter 4: information on cough and difficulty in breathing, pneumonia and bronchiolitis;
Chapter 10: information on essential supportive care including feeding, fluid and oxygen provision;
Annex 1: information on related practical procedures.
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