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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Birth defects surveillance: a manual for programme managers

World Health Organization (2014)

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National Guidelines for the Use of Antiretroviral Therapy in Adults and Adolescents

National Center for HIVAIDS, Dermatology and STD, Cambodia Ministry of Health (2012) CC

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Community Health Extension Workers Strategy in Uganda (2015/16- 2019/20)

Ministry of Health, Republic of Uganda (2016) C1

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Impact of health systems strengthening on coverage of maternal health services in Rwanda, 2000–2010: a systematic review

Maurice Bucagu, Jean M. Kagubare, Paulin Basinga, Fidèle Ngabo, Barbara K Timmons & Angela C Lee Reproductive Health Matters (2012) CC

From 2000 to 2010, Rwanda implemented comprehensive health sector reforms to strengthen the public health system, with the aim of reducing maternal and newborn deaths in line with Millennium Development Goal 5, among many other improvements in national health. Based on a systematic review of the lit... more

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Food Security Program Lifecycle Toolkit

Food for the Hungry (2006) CC

It is our hope and prayer that the guidance and multiple tools provided herein to manage the entire lifecycle of a food security program are useful to our food security staff, our local partners, and our fellow international Cooperating Sponsors throughout the world.

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Philippines: MNCHN Strategy Manual of Operations

Depar tment of Health, National Center for Disease Prevention and Control (2011) C1

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WHO recommendations: Policy of interventionist versus expectant management of severe pre-eclampsia before term

World Health Organization WHO (2018) C_WHO

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Working with Individuals, Families and Communities to Improve Maternal and Newborn Health. Module 5

World Health Organization WHO; PAHO Pan American Health Organization, Enfant du Monde (2017) C_WHO

A Toolkit for Implementation. Module 5: Finalizing, monitoring and evaluating the IFC action plan

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Shaping the Future: How Changing Demographics Can Power Human Development

Palanivel, T. , et al. United Nations Development Programme (2016) C1

Asia-Pacific Human Development Report

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National HIV/Syphilis sero-prevalence sentinel survey among pregnant women attending antenatal clinics in Nigeria

Federal Ministry of Health, Dept. of Public Health, National HIVSTI (2005) C1

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Analysing the response of a Teacher Training Institution to HIV and AIDS: A case study from Zambia

Lucinda Ramos UNESCO (2007) CC

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Community Health Volunteers' Decision Support System Project

P. Bakibinga, Kamande E. , Kisia L., et al. African Population and Health Research Centre APHRC (2018) C1

This report presents the key findings of the end-of-project assessment of households and community health volunteers, conducted in 2017 in the Kamukunji and Embakasi sub-counties of Nairobi, Kenya, for a Community Health Volunteers’ Decision Support System (CHV DSS) intervention project. The re... more

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West Africa Desert Locust Crisis Appeal (May–December 2020)

Food and Agriculture Organization of the United Nations FAO; reliefweb (2020) C2

Recent forecasts by the Food and Agriculture Organization of the United Nations (FAO) have indicated a risk of locust invasion in West Africa from June 2020. From East Africa, some swarms could reach the eastern part of the Sahel and continue westwards from Chad to Mauritania. Surveillance and co... more

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Policies to protect children from the harmful impact of food marketing: WHO guideline

World Health Organisation (WHO) (2023) C_WHO

Children continue to be exposed to powerful food marketing, which predominantly promotes foods high in saturated fatty acids, trans-fatty acids, free sugars and/or sodium and uses a wide variety of marketing strategies that are likely to appeal to children. Food marketing has a harmful impact on chi... more

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Journey of ART Programme in India. Story of a decade

National AIDSControl (NACO), Government of India; Ministry of Health and Family Welfare, et al. (2015) C1

Celebrating ten years of success 2004-2014

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Creating a Healing Environment - Volume II: Technical Papers

John Frederick International Labour Organization IPEC & Trafficking in Children-South Asia (TICSA) (2002) C1

Psycho-Social Rehabilitation and Occupational Integration of Child Survivors of Trafficking and Other Worst Forms of Child Labour |

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Antimicrobial Resistance Surveillance Guidance for the African Region

Africa Center for Disease Control and Prevention (2024) CC

Antimicrobials are medicines, including antibiotics, antivirals, antifungals, and antiparasitics, that are used to prevent and treat infections in humans, animals, and plants. Antimicrobial Resistance (AMR) arises when bacteria, viruses, fungi, and parasites no longer respond to these medicines, ren... more

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Vector control and the elimination of gambiense human African trypanosomiasis

World Health Organization WHO (2022) C_WHO

The main purpose of the meeting was to review tsetse control tools, activities and their contribution to the elimination of gHAT and the monitoring thereof. Seven endemic countries provided reports on recent and ongoing vector control interventions at the national level (Angola, Cameroon, Côte d’... more

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Essential Competencies for Basic Midwifery Practice

International Confederation of Midwives (2010)