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Chagas Clinical Research Platform Newsletter

Drugs for Neglected Diseases Initiative DNDi Latin America (2022) CC
To support its R&D activities on Chagas disease, DNDi launched the Chagas Clinical Research Platform (CCRP). The platform brings together partners, experts, and stakeholders to provide support for evaluation and development of new treatments for Chagas disease. The patient-centred platform aims to f... more
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The multidimensional comprehension of Chagas disease

Sanmatino, M.; Forsyth, C.; Avaria, A. et al. (2022) C2
Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 117: e200460, 2022 Integrating the multiple dimensions of the problem into a coherent approach adapted to field realities and needs represents an immense challenge, but the payoff is more effective and sustainable experiences, with higher social awareness... more
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Buruli ulcer : management of Mycobacterium ulcerans disease : a manual for health care providers
recommended

J. Buntine; Crofts, K. World Health Organization WHO (2001) CC
This manual is addressed to health care providers dealing with Mycobacterium ulcerans disease (Buruli ulcer). The manual aims to achieve a better understanding of the disease, its clinical presentation and its surgical management. The manual is aimed particularly at district health care providers. A... more
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Report of a WHO–FIND meeting on diagnostics for Buruli ulcer

WHO Tecnical Advisory Group and FIND (2018) CC
The meeting was held from 26 to 27 March 2018 to review and discuss the following topics: Advances and challenges in the use of fTLC, and new approaches to detecting mycolactone using monoclonal antibodies (mAbs). The status of development of rapid diagnostic tests (RDTs) targeting the MUL... more
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WHO Meeting on Buruli ulcer and other skin NTDs. Final report.

World Health Organization WHO (2019) C_WHO
The World Health Organization (WHO) convened a meeting of the Technical Advisory Group on Buruli ulcer at its headquarters in Geneva, Switzerland on 25 to 27 March 2019
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New generations free of HIV, syphilis, hepatitis B and Chagas disease in the Americas 2018

M. Alonso González; M. B. Mello; L. Sereno; et al. Pan American Health Organization; World Health Organization (Americas); Unicef (2019) C_WHO
- EMTCT Plus
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First meeting of the network on Buruli ulcer PCR laboratories in the WHO African Region Centre Pasteur du Cameroon, Yaoundé, 21–24 October 2019

World Health Organization WHO (2020) CC
Research to develop point-of-care tests is in progress. Treatment of Buruli ulcer comprises 8 weeks of combined antibiotics (rifampicin and clarithromycin). Complementary therapies such as wound care, skin graft and prevention of disability are needed in some cases to ensure full recovery. The targ... more
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WHO guideline for the treatment of visceral leishmaniasis in HIV co-infected patients in East Africa and South-East Asia 

World Health Organzation WHO WHO Neglected Tropical Diseases Department (2022) C_WHO
The leishmaniases are a group of diseases caused by Leishmania spp., which occur in cutaneous, mucocutaneous and visceral forms. They are neglected tropical diseases (NTDs), which disproportionately affect marginalized populations who have limited access to health care. HIV co-infected patients with... more
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Keeping the vector out: housing improvements for vector control and sustainable development

Kraef, C.; Röbbel, N. World Health Organization WHO (2017) C_WHO
Vector-borne diseases are responsible for 17% of the global burden of communicable diseases and more than 500 000 deaths annually. The ambitious global targets for the control of vector-borne diseases come in the context of the (re-)emergence of diseases, increasing resistances to insecticides and u... more
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Norms, standards and processes underpinning WHO vector control policy recommendations

World Health Organization WHO WHO (2020) C_WHO
This document outlines the evaluation process that WHO undertakes to assess novel tools and strategies targeted at VBDs. Its aim is to articulate the linkage between the generation of evidence that demonstrates public health impact of novel interventions, and the development of policy recommendation... more
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Vector control and the elimination of gambiense human African trypanosomiasis

World Health Organization WHO (2022) C_WHO
The main purpose of the meeting was to review tsetse control tools, activities and their contribution to the elimination of gHAT and the monitoring thereof. Seven endemic countries provided reports on recent and ongoing vector control interventions at the national level (Angola, Cameroon, Côte d’... more
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The Chagas disease study landscape: A systematic review of clinical and observational antiparasitic treatment studies to assess the potential for establishing an individual participant-level data plat

Maguire, B.J.; Dahal, P.; Rashan, S. et al. PLOS Neglected Tropical Diseases (2021) CC
PLoS Negl Trop Dis 15(8): e0009697. Chagas disease (CD), caused by the parasite Trypanosoma cruzi, affects ~6–7 million people worldwide. Significant limitations still exist in our understanding of CD. Harnessing individual participant data (IPD) from studies could support more in-depth analyses t... more
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Diagnosis and Clinical Management of Chagas Disease: An Increasing Challenge in Non-Endemic Areas

Suárez, C., Nolder, D., García-Mingo, A. et al. Research and reports in tropical medicine (2022) CC
Research and Reports in Tropical Medicine 2022:13 25–40. Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in Central, South America, Mexico and the South of the United States. It is an important cause of early mortality and morbidity, and it is associated with po... more
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Communication in neglected Tropical Diseases' elimination: A scoping review and call for action

Nieto-Sanchez C., Hatley DM, Gijalva MJ., et al. (2022) CC
PLoS Negl Trop Dis 16(10): e0009774. Although the practice of communication is often called upon when intervening asn involgvingcommunties affected by NTD's, the disciplinary framewokr of healt communication research has been largely absent from NTD strategies. To illustrate how practices conceptual... more
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Social Appropriation of Knowledge and its contributions to the prevention of cutaneous leishmaniasis in rural contexts

Paipilla, K., Castro-Arroyave, D., Grajales,L. et al. BMJ Innovations :234–239. doi:10.1136bmj (2022) CC
Cutaneous leishmaniasis (CL) is a neglected infectious endemic disease that is transmitted through the bite of a vector insect (sandfly) of the Lutzomyia genus,typical of rural geographical territories, and causes disfiguring skin ulcers and disabilities. It is estimated that CL affects between 600 ... more
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Integrating neglected tropical diseases into global health and development: fourth WHO report on neglected tropical diseases

World Health Organization WHO (2017) C_WHO
This fourth WHO report on neglected tropical diseases (NTDs) reviews the progress made towards achieving the Roadmap targets for 2020, noting the remaining challenges, then looks beyond 2020 to evaluate the changing global health and development landscape, considering the implications of integrating... more
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Responding to communicable and noncommunicable diseases: progress report 2020-2022

World Health Organization WHO (2023) C_WHO
Significant progress has been made in the eradication of three priority diseases in the African Region, as a result of extensive collaboration between the Regional Office, WHO country offices and countries. For example, in August 2020, the region was certified free of wild poliovirus. In the area of... more
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Vector-borne diseases: a handbook for pharmacists - Disease prevention, control, management and treatment

Gromek K., Hung M., Montero N. et al International Pharmaceutical Federation FIP (2020) C2
The Pharmaceutical Forum of the Americas (PFA) has previously published guidelines and organised campaigns for community pharmacists on the prevention, detection and control of arbovirus infections in 2018 with a grant from the FIP Foundation for Pharmacy Education and Research. Building on that exp... more
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An integrated, Sustainable Framework to Elimination of Communicable Diseases in the Americas. Concept Note

Pan American Health Organisation (PAHO) (2019) C_WHO
The objective of this concept note and the framework it outlines is the elimination of a group of CDs and the negative health effects they generate, which together create a tangible burden on affected individuals, their families and communities, and on health care systems throughout the Region. Thou... more
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WASH and Health working together: a ‘how-to’ guide for neglected tropical disease programmes
recommended

World Health Organization WHO (2023) C_WHO
2nd edition. This toolkit provides step-by-step guidance to NTD programme managers and partners on how to engage and work collaboratively with the WASH community to improve delivery of water, sanitation and hygiene services to underserved population affected by many neglected tropical diseases. The ... more