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Neglected Disease Research and Development: The Higher Cost of Lower Funding

G-Finder (2023) CC

Each year since 2007, G-FINDER has provided policy-makers, donors, researchers and industry with a comprehensive analysis of global investment into research and development of new products to prevent, diagnose, control or cure neglected diseases in low- and middle-income countries, making it the go... more

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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Tracking AMR Country Self Assessment Survey (TrACSS) 2022 Country Report Namibia

Food and Agriculture Organization of the United Nations FAO; UN environment programme; World Health Organization WHO; et al. (2022) C_WHO

Fact sheet

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Monitoring and Evaluation of the Global Action Plan on Antimicrobial Resistance: framework and recommended indicators

World Health Organization (WHO), Food and Agriculture Organization of the United Nations (FAO) and World Organisation for Animal Health (OIE) (2019) C_WHO

The GAP articulates five objectives for tackling AMR, and sets out the tasks required to achieve them, highlighting roles and responsibilities for country governments, the One Health Tripartite organizations (FAO, OIE and WHO) and other national and international partners. To ensure that all stakeh... more

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Nepal: Food and Nutrition Security Plan of Action ( FNSP ) A National Programme for Food and Nutrition Security

Ministry of Agricultur al Development (MOAD) (2013) C1

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Ukraine: FAO Humanitarian response update, 11 April 2022

Food and Agriculture Organization of the United Nations FAO (2022) C1

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Effective Implementation of Public Health and Social Measures in Zambia: Situational Analysis

WHO; Africa CDC; World Economic Forum et al. PERC (2020) C_WHO

PERC produces regional and member state situation analyses, updated regularly.

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Air pollution exposure—the (in)visible risk factor for respiratory diseases

Bălă, G.P.; Râjnoveanu, R.M.; Tudorache, E. et al. Environmental Science and Pollution Research (2021) CC

There is increasing interest in understanding the role of air pollution as one of the greatest threats to human health worldwide. Nine of 10 individuals breathe air with polluted compounds that have a great impact on lung tissue. The nature of the relationship is complex, and new or updated data are... more

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No podemos Esperar: Asegurar el Futuro contra las Infecciones Farmacorresistentes

IACG Interagency Coordination Group on Antimicral Resistance (2019) C_WHO

External Link

Plan Nacional Cáncer 2018 -2028

Ministerio de Salud - Chile (2018) CC

Actualmente, en el mundo, el cáncer produce millones de muertes al año, generando altos costos económicos y sociales, tanto por los valores asignados al tratamiento, como por el compromiso que genera en la productividad laboral de las personas directamente afectadas y de su entorno familiar y/o c... more

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DGVS Paraguay de vigilancia de la salud 2014

Ministerio de Salud Pública y Bienestar Social Paraguay (2014) C1

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Human and dog rabies prevention and control

World Health Organization WHO; Bill & Melinda Gates Foundation (2009) C_WHO

Report of the WHO/Bill & Melinda Gates Foundation Consultation. The Consultation was organized back-to-back with the first annual meeting of the International Coordinating Group of the BMGF-funded project for human and dog rabies elimination in developing countries, held at WHO headquarters, Geneva,... more

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Certified African Regional professionals: Level 1 Biological Waste Management

Africa Center for Disease Control and Prevention (2023) CC

The Africa Centres for Disease Control and Prevention (Africa CDC) Biosafety and Biosecurity Initiative was launched by the Africa CDC in April 2019 with the aim of strengthening the African Union (AU) Member States’ biosafety and biosecurity systems and enabling them to comply with national and i... more

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Global, regional, and national sex differences in the global burden of tuberculosis by HIV status, 1990–2019: results from the Global Burden of Disease Study 2019

GBD 2019 Tuberculosis Collaborators (2022) CC

Lancet Infect Dis 2022; 22: 222–4

External Link

Antimicrobial Resistance: A Manual for Developing National Action Plans

Food and Agriculture Organization of the United Nations FAO, World Health Organization WHO, World Organisation for Animal Health (2016) C_WHO

This manual for developing national action plans to address antimicrobial resistance has been developed at the request of the World Health Assembly to assist countries in the initial phase of developing new, or refining existing national action plans in line with the strategic objectives of the Glo... more

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WHO/OIE Manual on Echinococcosis in Humans and Animals: a Public Health Problem of Global Concern

WHOOIE (2001)

This Manual covers all important aspects of echinococcosis, including parasite biology and life-cycles, geographic distribution and prevalence, epidemiology, clinical presentation in humans and animals, diagnosis and treatment, as well as control and prevention using newly developed tools and method... more

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Ways out of the global health crisis

Seitz, K. Misereor, Brot für die Welt, Global Policy Forum GPF (2021) C1

Healthy people, healthy animals and a healthy environment worldwide with the One Health approach. The COVID-19 pandemic has drastically demonstrated just how close the link is between humans, animals, and the environment, and has highlighted and aggravated existing challenges. The destruction of na... more

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Technical brief on water, sanitation, hygiene (WASH) and wastewater management to prevent infections and reduce the spread of antimicrobial resistance (AMR)

World Health Organization WHO, Food and Agriculture Organization FAO, World Organization for Animal Health OIE (2020) C_WHO

Improvements in water sanitation and hygiene (WASH) and wastewater management in all sectors are critical elements of preventing infections and reducing the spread of antimicrobial resistance (AMR) as identified in the Global Action Plan to combat AMR. Yet, at present, WASH and wastewater management... more

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Connecting Global Priorities: Biodiversity and Human Health

World Health Organization WHO (2015) C_WHO

Healthy communities rely on well-functioning ecosystems. They provide clean air, fresh water, medicines and food security. They also limit disease and stabilize the climate. But biodiversity loss is happening at unprecedented rates, impacting human health worldwide, according to a new state of knowl... more

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Uganda: Antimicrobial Resistance National Action Plan 2018-2023

Government of Uganda (2018) C2

The current trend in AMR in Uganda and globally is rising and calls for immediate action. The 71st UN General Assembly (UNGA), the 68th World Health Assembly, and organizations including the World Health Organization (WHO), the Food and Agriculture Organization (FAO), and the World Organization for ... more