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Topics in Antiviral Medicine, March 4, 2025
The Lancet HIV. Volume 12, Issue 10e712-e721October 2025. This article from The Lancet HIV estimates the impact of the PEPFAR funding pause for PrEP on HIV infections in sub-Saharan Africa.
Rwanda’s mountainous topography makes ground transportation of medical supplies unreliable — some roads stretching into rural areas remain uncared for and unpaved. Between 25 and 40 per cent of all temperature-sensitive medical supplies sent from urban centres to rural health clinics are wasted
...
because of an unreliable cold-chain infrastructure. Rural clinics are also often subject to stockouts, and patients in need of specialized blood products, drugs and other supplies are unable to acquire them. Zipline, a US-based health logistics company, aims to address the issue of access to medical supplies, largely leapfrogging traditional modes of transportation and various obstacles. Zipline uses drones to deliver blood and other routine and emergency medical supplies from distribution centres to district hospitals and rural health centres.
Although the company has been celebrated in the media for its operations, there is little scholarly work on its operations and performance. This has led to some confusion over its scale. We aimed to gain insight into the details of Zipline’s business model, including the infrastructure, regulations and government support that make Zipline possible, and to understand its impact on health outcomes in Rwanda. Our work was entirely based on published materials since our research was conducted during the COVID-19 pandemic.
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Progress on the sustainable development goals.
Since 2008, the HIV and AIDS Data Hub has been providing decision-makers and experts high quality, accessible and up-to-date data on HIV in Asia and the Pacific. Working with many regional and national partners, we compile, update and analyse evidence on the HIV epidemic in Asia and the Pacific. In
...
this region, HIV is clustered and concentrated among specific sub-populations, as well as within certain geographical areas in countries, hence the Data Hub prominently profiles subnational and key populations at higher risk data. Effective policies and interventions require the best available evidence, which is what the Data Hub aims to provide in one convenient web site.
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This document is itended as a quick guide of healtcare workers involved in clincial management
Nature Sci Rep 15, 35329 (2025). https://doi.org/10.1038/s41598-025-19261-7
Front Psychiatry. 2022 Aug 11;13:937723. doi: 10.3389/fpsyt.2022.937723. PMID: 36061286; PMCID: PMC9429610. The review findings show that there exist several diverse interventions that promote mental health among adolescents in sub-Saharan Africa. These interventions can be implemented in diverse se
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ttings including schools, communities, health facilities, and camps, and can be delivered by lay persons.
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These messages may be used as stand-alone resources, and also could be used as a supplement to The Essential Package, a comprehensive set of tools and guides for program managers and service providers supporting programs that address the unique needs and competencies of vulnerable children in a holi
...
stic way.
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A job aid for cadres supporting caregivers of children and adolescents living with HIV (ages 0-14) in Orphans and Vulnerable Children (OVC) Programs
A Training Manual for Para-Social Workers. A Project of the Social Work HIV/AIDS
Partnership for Orphans Vulnerable Children in Tanzania. This training presentation is continually being evaluated and updated to
reflectcurrent needs and best practices. It should be viewed as work in progress
J Int AIDS Soc. 2022 Nov;25(11):e25970. doi: 10.1002/jia2.25970. PMID: 36377082; PMCID: PMC9663860. These reassuring findings suggest that dolutegravir and raltegravir are effective and safe as preferred regimens in children and adolescents living with HIV. With the rollout of dolutegravir in paedia
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tric populations already underway, it is critical that data are collected on safety and effectiveness in infants, children and adolescents, including on longer-term outcomes, such as weight and metabolic changes.
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J Int AIDS Soc. 2025 Jun;28(6):e26526. doi: 10.1002/jia2.26526. PMID: 40515449; PMCID: PMC12166130.
JAMA. 2025;333(7):609–628. doi:10.1001/jama.2024.24543
Lancet HIV 2019 Published Online March 15, 2019 http://dx.doi.org/10.1016/S2352-3018(19)30052-9
Analytical antiretroviral treatment interruption (ATI) is an important feature of HIV research, seeking to achieve
sustained viral suppression in the absence of antiretroviral therapy (ART) when the goa
...
l is to measure effects of
novel therapeutic interventions on time to viral load rebound or altered viral setpoint. Trials with ATIs also intend
to determine host, virological, and immunological markers that are predictive of sustained viral control off ART.
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A Flipchart for Child an Adolescent Disclosure Counseling (CADC) SOP3
Levin, L.; M. Vujovic, and J. Turner
Ministry of Health, South Africa; PEPFAR; USAID; Right to Care; et al.
(2024)
C1
Right to Care mini flipster
The paper “Artificial Intelligence for Public Health Surveillance in Africa: Applications and Opportunities” examines how artificial intelligence (AI) can improve public health systems across Africa, particularly in low-resource settings. It explores how machine learning and other AI techniques
...
are being used for disease detection, outbreak prediction, real-time surveillance, and health resource management.
The authors focus on major public health challenges such as HIV, cholera, Ebola, measles, tuberculosis, malaria, COVID-19, and mental health. Through numerous case studies, the paper shows that AI can enhance the accuracy and speed of disease detection, predict outbreaks more effectively than traditional methods, support vaccination strategies, and optimize healthcare resource allocation. At the same time, it discusses important barriers to implementation, including limited data quality, infrastructure constraints, ethical concerns, and shortages of technical expertise.
Overall, the paper highlights AI’s strong potential to strengthen disease surveillance and health outcomes in Africa while emphasizing the need for careful integration, improved data systems, and supportive policy frameworks.
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Ewha Med J Volume 47(3); 2024
The article “Reporting Guidelines for Community Outbreak Investigation (G-CORE): A Study Protocol” describes the development of standardized reporting guidelines for investigations of infectious disease outbreaks in community settings. The authors highlight that ou
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tbreak reports are often inconsistent and lack important epidemiological information, which makes it difficult to compare studies and apply findings to public health practice. The G-CORE project aims to create a structured guideline that improves the quality, transparency, and completeness of outbreak investigation reports. By establishing clear reporting standards, the guideline intends to support researchers and public health professionals in documenting outbreaks more systematically and to facilitate better communication, analysis, and response to infectious disease events.
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The Health Emergency and Disaster Risk Management
Chan E.Y.Y., Huang Z., Hung K.K.C. et al
United Nations Office for Disaster Risk Reduction UNDRR
(2022)
CC
An emerging framework for achieving synergies among the Sendai Framework, the 2030 Agenda for Sustainable Development, the New Urban Agenda and the Paris Agreement. This paper discusses the potential of the Health Emergency and Disaster Risk Management (Health-EDRM) Framework in promoting syne
...
rgies in pursing risk- resilient sustainable development pathways via conceptual analysis of the key roles of health and Health-EDRM in the major international risk-resilient and sustainable development agendas of the Sendai Framework, the 2030 Agenda for Sustainable Development, the New Urban Agenda and the Paris Agreement. It first analyses the Health-EDRM Framework, which is a comprehensive, systematic, cross-sectoral, and interdisciplinary endeavour of the World Health Organization and its health and non- health partners. The four key international risk-resilient and sustainable development agendas are then analysed in detail to explore how they can be interlinked and synergised under the Health-EDRM Framework.
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Guide to revision of national pandemic influenza preparedness plans - Lessons learned from the 2009 A(H1N1) pandemic
Brown C., Ciotti M., Hegermann-Lindencrone M., et al
European Centre for Disease Prevention and Control (ECDC), WHO Regional Office for Europe
(2017)
C_WHO
The document “Guide to revision of national pandemic influenza preparedness plans – Lessons learned from the 2009 A(H1N1) pandemic” provides guidance for countries on how to improve and update their national pandemic preparedness plans. It is based on lessons learned from the 2009 influenza pa
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ndemic and aims to help governments strengthen their readiness for future pandemics. The report outlines key components of effective pandemic planning, including risk assessment, coordination between sectors, communication strategies, healthcare system preparedness, vaccination and antiviral strategies, and business continuity planning. It also emphasizes the importance of international cooperation and flexible planning that can adapt to different pandemic scenarios. Overall, the guide serves as a framework to support countries in developing stronger, more coordinated responses to future influenza pandemics.
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