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Target product profile for a point-of-care diagnostic test for dermal leishmaniases

World Health Organization WHO (2022) C_WHO

In 2007, the Sixtieth World Health Assembly adopted resolution WHA60.13 on control of leishmaniasis, urging Member States, among other actions: to strengthen prevention, active detection and treatment of cases of both cutaneous and visceral leishmaniasis in order to decrease the disease burde... more

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Guidance for country validation of viral hepatitis elimination and path to elimination

World Health Organization WHO (2023) C_WHO

Building on the 2021 Interim guidance, this second version and update, incorporates the lessons and feedback from the hepatitis pilots that successfully demonstrated the feasibility of measuring hepatitis B and C impact targets to demonstrate elimination, whilst highlighting challenges caused by hig... more

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Water, Sanitation and Hygiene and Infection Prevention and Control in Cholera Treatment Structures

UN Children's Fund UNICEF Global Task Force on Cholera (2019) C_UNICEF

Technical Note: Cholera treatment facilities provide inpatient care for cholera patients during outbreaks. Proper case management and isolation of cholera patients is essential to prevent deaths and help control the spread of the disease. Traditionally, these structures have been referred to as ch... more

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HEARTS. Technical package for cardiovascular disease management in primary health care. Evidence-based treatment protocols

World Health Organization WHO, et al. (2018) C_WHO

In many low- and middle-income countries, there is a wide gap between evidencebased recommendations and current practice. Treatment of major CVD risk factors remains suboptimal, and only a minority of patients who are treated reach their target levels for blood pressure, blood sugar and blood choles... more

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Antimicrobial resistance and causes of non-prudent use of antibiotics in human medicine in the EU

European Commission (2017) C1

Antimicrobial resistance (AMR) is an increasing worldwide public health problem with important implications for the European Union (EU). When antibiotics become ineffective, bacterial infections lead to increased morbidity, use of healthcare, mortality and cost. Globally, estimates suggest that ... more

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Resource mobilisation for Antimicrobial Resistance (AMR): Getting AMR into plans and budgets of government and development partners / Nigeria country level report

World Health Organization WHO (2018) C_WHO

The most significant finding of the case study for integrating antimicrobial resistance (AMR)into existing programs and mobilising resources for funding in Nigeria, is that most of the AMR activities within the Nigerian National Action Plan (NAP)canalready be incorporated within exi... more

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Guidelines for the Clinical Diagnosis and Treatment of Dengue, Chikungunya, and Zika

Pan American Health Organisation PAHO (2022) C_WHO

Evidence-based guidelines are one of the most useful tools for improving public health and clinical practice. Their purpose is to formulate interventions based on strong evidence of efficacy, avoid unnecessary risks, use resources efficiently, reduce clinical variability and, in essence, improve hea... more

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Continental Framework on Strengthening Mortality Surveillance Systems in Africa

Africa Center for Disease Control and Prevention (2023) CC

The importance of robust mortality surveillance systems cannot be overstated in an era marked by increasing global health challenges where health threats loom large and population dynamics continue to evolve. Accurate and timely mortality data is essential for identifying trends and detecting emergi... more

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African Union Health Information Exchange Guidelines and Standards

Africa Center for Disease Control and Prevention (2023) CC

The application of digital health technology is growing at a rapid rate in Africa, with the goals of improving the delivery of healthcare services and more effectively reaching out to remote and underserved communities. The lack of enabling guidelines and standards across the continent, on the other... more

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Guidance on pooled testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
recommended

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C1

The purpose of this document is to provide guidance on the use of pooled sample testing strategy in coronavirus disease (COVID-19) testing laboratories of the African Union Member States for scaling up SARS-CoV-2 nucleic acid testing capacity with the available resources. The current document descr... more

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Generic protocol for a population-based, age- and gender- stratified sero-survey study for SARS-CoV-2

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C1

The number of confirmed COVID-19 cases detected and reported in each country is influenced by many factors including limited access and/or utilization of healthcare and COVID-19 testing, limited surveillance, lack of knowledge amongst the population about when to seek testing, an asymptomatic pres... more

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Action Protocol for Enhanced SARI and ILI Surveillance for COVID-19 in Africa

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C2

March 2020 The number of African Union Member States reporting COVID- 19 cases is increasing and there is a likelihood of community transmission. The WHO recently modified the COVID-19 suspect case definition to include severe acute respiratory infection and advises testing of all severe acute res... more

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Handbook on TB laboratory diagnostic methods in the European Union

European Centre for Disease Prevention and Control (2016) C1

The aim of this handbook is to provide network members and other laboratories involved in the diagnosis of tuberculosis, with an agreed list of key diagnostic methods and their protocols in various areas of TB diagnosis, ranging from microbiological diagnosis of active TB to the diagnosis of latent ... more

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Thematic report: Stigma and discrimination

T. Noori; A. Pharris European Centre for Disease Prevention and Control (2013) C2

Monitoring implementation of the Dublin Declaration on Partnership to Fight HIV/AIDS in Europe and Central Asia: 2012 progress Special Report

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The European Union One Health 2020 Zoonoses Report

European Centre for Disease Prevention and Control ECDC; EFSA EFSA Journal (2021) CC

This report of the EFSA and ECDC presents the results of zoonoses monitoring activities carried out in 2020 in 27 EU Member States (MS) and nine non-MS. Key statistics on zoonoses and zoonotic agents in humans, food, animals and feed are provided and interpreted historically.

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Monkeypox multi-country outbreak. Rapid Risk Assessment

European Centre for Disease Prevention and Control (ECDC) (2022) C2

Cases of monkeypox (MPX) acquired in the EU have recently been reported in nine EU Member States (Austria, Belgium, France, Germany, Italy, Portugal, Spain, Sweden, and the Netherlands). Monkeypox (MPX) does not spread easily between people. Human-to-human transmission occurs through close contact ... more

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Interim advice for public health authorities on summer events during the monkeypox outbreak in Europe, 2022

European Centre for Disease Prevention and Control ECDC (2022) C1

14 June 2022. The aim of this document is to provide concise advice to public health authorities and guide their prevention, awareness-raising and behaviour change interventions before, during and after upcoming summer events.

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Enhanced COVID-19 Surveillance at the Community Level in Africa

African Union; Africa CDC Centres for Disease Control and Prevention (2021) CC

The strategy recommends that AU Member States should enhance, where feasible, existing COVID-19 surveillance to include: Community-based surveillance to detect symptomatic cases early for treatment and to avert viral transmission; Sentinel surveillance in high-risk populations to detect ... more

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Mpox Testing Strategy - November 2024

Africa Center for Disease Control and Prevention (2024) CC

Mpox is an emerging zoonotic disease caused by the mpox virus, a member of the Orthopoxvirus genus closely related to the variola virus that causes smallpox. Mpox was first discovered in 1958 when outbreaks of a pox-like disease occurred in monkeys kept for research. The first human case was recorde...d in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox and since then the infection has been reported in a number of African countries. Mpox can spread in humans through close contact, usually skin-to-skin contact, including sexual contact, with an infected person or animal, as well as with materials contaminated with the virus such as clothing, beddings and towels, and respiratory droplets in prolonged face to face contact. People remain infectious from the onset of symptoms until all the lesions have scabbed and healed. The virus may spread from infected animals through handling infected meat or through bites or scratches. Diagnosis is confirmed by polymerase chain reaction (PCR) testing of material from a lesion for the virus’s DNA. Two separate clades of the mpox virus are currently circulating in Africa: Clade I, which includes subclades Ia and Ib, and Clade II, comprising subclades IIa and IIb. Clade Ia and Clade Ib have been associated with ongoing human-to-human transmission and are presently responsible for outbreaks in the Democratic Republic of the Congo (DRC), while Clade Ib is also contributing to outbreaks in Burundi and other countries. In 2022‒2023 mpox caused a global outbreak in over 110 countries, most of which had no previous history of the disease, primarily driven by human-to-human transmission of clade II through sexual contact. In just over a year, over 90,000 cases and 150 deaths were reported to the WHO. For the second time since 2022, mpox has been declared a global health emergency as the virus spreads rapidly across the African continent. On 13 Aug 2024, Africa CDC declared the ongoing mpox outbreak a Public Health Emergency of Continental Security (PHECS), marking the first such declaration by the agency since its inception in 2017.7 This declaration empowered the Africa CDC to lead and coordinate responses to the mpox outbreak across affected African countries. On August 14, 2024, the WHO declared the resurgence of mpox a Public Health Emergency of International Concern (PHEIC) emphasizing the need for coordinated international response. As of August 2024, Mpox has expanded beyond its traditional endemic regions, with new cases reported in countries including Sweden, Thailand, the Philippines, and Pakistan. Sweden has confirmed its first case of Clade 1 variant, which has been rapidly spreading in Africa, particularly in DRC. The emergence of this new variant raises concerns about its potential for higher lethality and transmission rates outside Africa. more

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Medical PPE production in Africa: Promoting Local Manufacturers to support the COVID-19 Response (Workshop report)

African Union; Africa CDC Centres for Disease Control and Prevention (2020) C1

The global pandemic has highlighted fragility in international supply chains and the dependency of many African countries on imported personal protective equipment (PPE). Market pressures have also increased prices for imported supplies and put additional pressure on areas with limited resources for... more

Guidance on pooled testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recommended

Guidance on pooled testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
recommended