Background: Disability is a complex concept involving physical impairment, activity limitation, and participation restriction. The
Washington Group developed a set of questions on six functional domains (seeing, hearing, walking, remembering, self-care, and
communicating) to allow collection of co...mparable data on disability. We aimed to improve understanding of prevalence and correlates of disability in this low-income setting in Malawi.
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The protozoan parasite Trypanosoma cruzi causes Chagas disease, an important public health problem throughout Latin America. Current therapeutic options are characterised by limited efficacy, long treatment regimens and frequent toxic side-effects. Advances in this area have been compromised by gaps... in our knowledge of disease pathogenesis, parasite biology and drug activity. Nevertheless, several factors have come together to create a more optimistic scenario. Drug-based research has become more systematic, with increased collaborations between the academic and commercial sectors, often within the framework of not-for-profit consortia. High-throughput screening of compound libraries is being widely applied, and new technical advances are helping to streamline the drug development pipeline. In addition, drug repurposing and optimisation of current treatment regimens, informed by laboratory research, are providing a basis for new clinical trials. Here, we will provide an overview of the current status of Chagas disease drug development, highlight those areas where progress can be expected, and describe how fundamental research is helping to underpin the process.
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Air pollution from road traffic is a serious health hazard, and people with preexisting respiratory disease may be at increased risk. We investigated the effects of short-term exposure to diesel traffic in people with asthma in an urban, roadside environment.
Since the description of the first case of COVID-19 in Wuhan, Hubei province in China, in December 2019, much knowledge has been accumulated about the dynamics of evolution of the SARS-CoV-2 virus, contagion, disease progression, prevention and treatment.
Análisis de las inequidades en salud reproductiva, materna, neonatal, de la niñez y de la adolescencia en América Latina y el Caribe para guiar la formulación de políticas
В методических рекомендациях на основе результатов научных исследований, опыта проведения психологической работы с медицинскими работниками сформированы орган...зационно-методические подходы проведения групп- аналитической супервизии, баллинтовской группы, тренинга по повышению стрессоустойчивости персонала. Описаны цели, задачи и содержательная структура предлагаемых форм групповой психологической работы, способствующих снижению профессионального бремени, повышению квалификации персонала, качества оказываемой помощи. Методические рекомендации предназначены для специалистов, работающих в психиатрических учреждениях.
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A One Health Response. A Briefing Note
Supplement Article
Antiretrovirals to Prevent HIV Infection • CID 2015:60 (Suppl 3) • S159 - S160
Flipchart.
A job aid for use by health workers when educating clients and their family members about cancer; Each page has a large illustration to share with patients, with talking points on the reverse side; Presents similar content to patient/caregiver booklet; Includes a counseli...ng page on patient rights (e.g., right to confidentiality, right to be treated with dignity and respect).
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Joint Action for Results
UNAIDS Outcome Framework: Business Case 2009–2011
Informe sobre poplaciones clave.
With the growing prevalence of type 2 diabetes, particularly in emerging countries, its management in the context of available resources should be considered. International guidelines, while comprehensive and scientifically valid, may not be appropriate for regions such as Asia, Latin America or Afr...ica, where epidemiology, patient phenotypes, cultural conditions and socioeconomic status are different from America and Europe. Although glycaemic control and reduction of micro- and macrovascular outcomes remain essential aspects of treatment, access and cost are major limiting factors; therefore, a pragmatic approach is required in restricted-resource settings. Newer agents, such as sodium–glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists in particular, are relatively expensive, with limited availability despite potentially being valuable for patients with insulin resistance and cardiovascular complications. This review makes a case for the role of more accessible second-line treatments with long-established efficacy and affordability, such as sulfonylureas, in the management of type 2 diabetes, particularly in developing or restricted-resource countries.
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Guidelines for Treatment and Management of Heart Failure in Indonesia