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Cutaneous Leishmaniasis: Urgent need to develop more effective and user-friendly point-of-care diagnostic tools

DNDi redeLEISH (2022) CC

Leishmaniasis is a complex vector-borne disease involving in its transmission several species of protozoan parasites called Leishmania, a wide variety of animal reservoirs and phlebotomine sandflies vectors. Cutaneous Leishmaniasis (CL) is the most common form of the disease, and its clinical manife... more

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A guillain-barre syndrome revealing cutaneous leishmaniasis in an immunocompetent adolescent

Mamadou K., Diop, A., Mbodji, A. et al. Pan African Medical Journal PAMJ - Clinical Journal (2020) CC

Guillain-Barre Syndrome (GBS) is an acute autoimmune polyradiculoneuropathy that often follows an antecedent infection. Leishmaniasis is a zoonosis due to a flagellate protozoan of the Leishmania genus and transmitted by the sandfly. Here we report a 15 years old teenager who presented with an ascen... more

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Serious adverse events following treatment of visceral leishmaniasis: A systematic review and meta-analysis

Singh-Phulgenda, S., Dahal, P., Ngu, R. et al. PLOS Neglected Tropical Diseases (2021) C1

Despite a historical association with poor tolerability, a comprehensive review on safety of antileishmanial chemotherapies is lacking. We carried out an update of a previous systematic review of all published clinical trials in visceral leishmaniasis (VL) from 1980 to 2019 to document any reported ... more

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Leishmaniasis Treatment Market Size, Share, Industry Growth, Trend, Business Opportunities, Challenges, Drivers and Restraint Research Report by 2028

Reports and Data BioSpace (2022) C1

High prevalence of target diseases in rural and developing nations, increased prevalence of malnutrition across the globe, lack of hygiene and poor sanitation facilities, Migratory patterns of population, introduction of new chemical entity in the field of therapeutics, favorable government regulati... more

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Chagas Disease

Cleveland Clinic (2021) C1

Chagas disease is a tropical parasitic infection transmitted by crawling, blood-sucking insects (kissing bugs). You may have flu-like symptoms or none at all. But the disease can lead to life-threatening complications. With prompt treatment, most people with Chagas disease, also known as American tr... more

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Worldwide Control and Management of Chagas Disease in a New Era of Globalization: a Close Look at Congenital Trypanosoma cruzi Infection.

Abras A., Ballart C., Fernández-Arévalo A., et al. Clinical Microbiology Reviews (2022) CC

Population movements have turned Chagas disease (CD) into a global public health problem. Despite the successful implementation of subregional initiatives to control vectorial and transfusional Trypanosoma cruzi transmission in Latin American settings where the disease is endemic, congenital CD (cCD... more

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Surveillance data for human leishmaniasis indicate the need for a sustainable action plan for its management and control, Greece, 2004 to 2018

Tzani M., Barrasa, A., Vakali, A. et al. Euro Surveillance (2020) CC

Leishmaniasis is a parasitic disease caused by intracellular protozoan parasites of the genus Leishmania (Trypanosomatidae family); it is endemic in more than 98 countries worldwide [1]. Visceral (VL) and cutaneous (CL) leishmaniasis are the most common forms of the disease. VL causes a systemic dis... more

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Leishmaniasis: Leishmaniasis is an infection transmitted by the bite of infected phlebotomine sandfly

Travel Health Pro (2022) CC

Leishmaniasis is an infection caused by the Leishmania parasites. The infection is transmitted by the bite of infected phlebotomine sandfly. There are over 20 types of Leishmania parasites which cause infection in people and 30 different types of sand flies to spread infection. Leishmaniasis is wide... more

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Leishmaniasis

World Health Organization WHO (2023) C_WHO

There are 3 main forms of leishmaniases: visceral (the most serious form because it is almost always fatal without treatment), cutaneous (the most common, usually causing skin ulcers), and mucocutaneous (affecting mouth, nose and throat). Leishmaniasis is caused by protozoan parasites which are tra... more

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Health professionals’ knowledge about prevention and control of leishmaniosis

Alves, G., de Oliveira T., Nodari N. et al. Journal of Community Medicine (2019) CC

Leishmaniasis is an important worldwide disease with a zoonotic potential that presenting visceral and cutaneous clinical forms. The domestic dog is seen as the main reservoir of Leishmania spp. and for this reason, it is the target of the control program in some countries. The health professiona... more

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Epidemiology of Chagas disease in pregnant women and congenital transmission of Trypanosoma cruzi in the Americas: systematic review and meta-analysis

Santana, K.; Oliveira, L.; Barros de Castro, D. et al. Tropical medicine & international health (2020) CC

Objective To estimate the prevalence of Chagas disease in pregnant women and the vertical transmission of the disease. Methods Observational studies were identified from eight electronic databases, and details on study design, population and prevalence of Chagas disease were extracted. The data... more

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WHO guideline on control and elimination of human schistosomiasis

World Health Organization WHO (2022) CC

Goal and objectives of the guideline The goal of this guideline is to provide evidence-based recommendations to countries in their efforts to accomplish schistosomiasis morbidity control and elimination as a public health problem, and to move towards interruption of transmission. The recommendatio... more

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Diagnosis and Clinical Management of Chagas Disease: An Increasing Challenge in Non-Endemic Areas

Suárez, C., Nolder, D., García-Mingo, A. et al. Research and reports in tropical medicine (2022) CC

Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in Central, South America, Mexico and the South of the United States. It is an important cause of early mortality and morbidity, and it is associated with poverty and stigma. A third of the cases evolve into chronic... more

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The Chagas disease study landscape: A systematic review of clinical and observational antiparasitic treatment studies to assess the potential for establishing an individual participant-level data plat

Maguire, B.J.; Dahal, P.; Rashan, S. et al. PLOS Neglected Tropical Diseases (2021) CC

Chagas disease (CD), caused by the parasite Trypanosoma cruzi, affects ~6–7 million people worldwide. Significant limitations still exist in our understanding of CD. Harnessing individual participant data (IPD) from studies could support more in-depth analyses to address the many outstanding resea... more

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Global, Regional, and National Trends of Chagas Disease from 1990 to 2019: Comprehensive Analysis of the Global Burden of Disease Study

Gómez-Ochoa, S., Rojas, L., Echeverría, L., Global Heart Journal (2022) CC

Chagas disease (CD) is a neglected tropical disease, endemic in Latin America, but due to migration and environmental changes it has become a global public health issue.

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Estimating chagas disease prevalence and number of underdiagnosed, and undertreated individuals in Spain

Navarro, M., Reguero, L., Subirà, C. et al. Travel Medicine and Infectious Disease (2022) CC

Chagas disease constitutes a public health problem, and Spain is the non-endemic country with the highest burden of disease outside the Americas. It represents a model for non-endemic countries regarding health policies to control the disease. This study is aimed to generate estimates of the T.cruzi... more

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New Therapeutics for Chagas Disease: Charting a Course to Drug Approval

Man, A. & Segal, F. IntechOpen (2022) CC

Little progress has been made since the 1960s and 1970s to widen the therapeutic arsenal against Trypanosoma cruzi, the causative pathogen of Chagas disease, which remains a frustrating and perplexing infectious disease. This chapter focuses on the strategic and operational challenges in the clinica... more

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A systematic review of historical and current trends in Chagas disease

Álvarez-Hernández D., García-Rodríguez-Arana R., Ortiz-Hernández A. et al. Therapeutic advances in infectious disease (2021) CC

Chagas disease (CD) is caused by Trypanosoma cruzi. When acquired, the disease develops in stages. For diagnosis, laboratory confirmation is required, and an extensive assessment of the patient’s health should be performed. Treatment consists of the administration of trypanocidal drugs, which may... more

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An Update on the Knowledge of Parasite–Vector Interactions of Chagas Disease

Schaub, G. Research and Reports in Tropical Medicine (2022) CC

This review focusses on the interactions between the etiologic agent of Chagas disease, Trypanosoma cruzi, and its triatomine vector. The flagellate mainly colonizes the intestinal tract of the insect. The effect of triatomines on trypanosomes is indicated by susceptibility and refractoriness phenom... more