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World Chagas Disease Day: finding and reporting every case

World Health Organization WHO (2022) CC
Today is World Chagas Disease Day. This year’s theme is Finding and reporting every case to defeat Chagas disease. Despite progress, the global case detection rate for Chagas disease is low (estimated to be around 10%), posing a substantial barrier to accessing treatment and care and in prevent... more
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Describing nearly two decades of Chagas disease in Germany and the lessons learned: a retrospective study on screening, detection, diagnosis, and treatment of Trypanosoma cruzi infection from 2000 – 2

Guggenbühl Noller, J.M., Froeschl, G., Eisermann, P. et al. BMC Infectious Diseases (2020) CC
The highly complex and largely neglected Chagas disease (CD) has become a global health problem due to population movements between Latin America and non-endemic countries, as well as non-vectorial transmission routes. Data on CD testing and treatment from routine patient care in Germany of almost t... more
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Ancient pathogens provide a window into health and well-being

Lewis, C. Jr., Akinyi, M., DeWitte, S. et al. Proceedings of the National Academy of Sciences PNAS (2022) CC
This perspective draws on the record of ancient pathogengenomes and microbiomes illuminating patterns of infectious disease over the course of the Holocene in order toaddress the following question. How did major changes inliving circumstances involving the transition to and intensification of farmi... more
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Consulta técnica regional OPS/MSF sobre Organización y estructura de la atención médica del enfermo o infectado por Trypanosoma cruzi (enfermedad de Chagas)

Organización Panamericana de la Salud (2005) C2
El desarrollo, desde 1991, de las Iniciativas Subregionales de Control de la Enfermedad de Chagas, y los avances de conocimiento en materia de diagnóstico y manejo de la infección/enfermedad de Chagas, llevan a la necesidad ética, y operativamente imperiosa, de estructurar el diagnóstico, atenci... more
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Chagas Disease

Cleveland Clinic (2021) C1
Chagas disease is a tropical parasitic infection transmitted by crawling, blood-sucking insects (kissing bugs). You may have flu-like symptoms or none at all. But the disease can lead to life-threatening complications. With prompt treatment, most people with Chagas disease, also known as American tr... more
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Chagas Disease - Printable resources

CDC United States (2022) CC
Education and information about Chagas Disease, Triatomine bugs, Kissing Bugs, fact sheets, information for special groups, prevention and control, epidemiology, diagnosis and treatment for Health Professionals.
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Guidance Note: IPC in Schools during AWD/Cholera Outbreaks

UN Children's Fund UNICEF; WASH Cluster (2023) C_UNICEF
WASH in schools during a cholera response is important due to the strong correlation between WASH and IPC. Not only can it impact the health and well-being of students and staff but also facilitate the potential spread of the disease via the congregation of children and adults from multiple househol... more
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Informing vaccination programs: a guide to the design and conduct of dengue serosurveys

World Health Organization WHO (2020) C_WHO
In this document, recommendations are provided on designing and implementing a cross-sectional serosurvey using school-based sampling to estimate age-specific DENV seroprevalence to inform a country’s national dengue vaccination program. The document includes recommendations for methods for ... more
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Epidemiology of Chagas disease in pregnant women and congenital transmission of Trypanosoma cruzi in the Americas: systematic review and meta-analysis

Santana, K.; Oliveira, L.; Barros de Castro, D. et al. Tropical medicine & international health (2020) CC
Objective To estimate the prevalence of Chagas disease in pregnant women and the vertical transmission of the disease. Methods Observational studies were identified from eight electronic databases, and details on study design, population and prevalence of Chagas disease were extracted. The data... more
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The Chagas disease study landscape: A systematic review of clinical and observational antiparasitic treatment studies to assess the potential for establishing an individual participant-level data plat

Maguire, B.J.; Dahal, P.; Rashan, S. et al. PLOS Neglected Tropical Diseases (2021) CC
Chagas disease (CD), caused by the parasite Trypanosoma cruzi, affects ~6–7 million people worldwide. Significant limitations still exist in our understanding of CD. Harnessing individual participant data (IPD) from studies could support more in-depth analyses to address the many outstanding resea... more
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Global, Regional, and National Trends of Chagas Disease from 1990 to 2019: Comprehensive Analysis of the Global Burden of Disease Study

Gómez-Ochoa, S., Rojas, L., Echeverría, L., Global Heart Journal (2022) CC
Chagas disease (CD) is a neglected tropical disease, endemic in Latin America, but due to migration and environmental changes it has become a global public health issue.
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Estimating chagas disease prevalence and number of underdiagnosed, and undertreated individuals in Spain

Navarro, M., Reguero, L., Subirà, C. et al. Travel Medicine and Infectious Disease (2022) CC
Chagas disease constitutes a public health problem, and Spain is the non-endemic country with the highest burden of disease outside the Americas. It represents a model for non-endemic countries regarding health policies to control the disease. This study is aimed to generate estimates of the T.cruzi... more
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New Therapeutics for Chagas Disease: Charting a Course to Drug Approval

Man, A. & Segal, F. IntechOpen (2022) CC
Little progress has been made since the 1960s and 1970s to widen the therapeutic arsenal against Trypanosoma cruzi, the causative pathogen of Chagas disease, which remains a frustrating and perplexing infectious disease. This chapter focuses on the strategic and operational challenges in the clinica... more
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A systematic review of historical and current trends in Chagas disease

Álvarez-Hernández D., García-Rodríguez-Arana R., Ortiz-Hernández A. et al. Therapeutic advances in infectious disease (2021) CC
Chagas disease (CD) is caused by Trypanosoma cruzi. When acquired, the disease develops in stages. For diagnosis, laboratory confirmation is required, and an extensive assessment of the patient’s health should be performed. Treatment consists of the administration of trypanocidal drugs, which may... more
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An Update on the Knowledge of Parasite–Vector Interactions of Chagas Disease

Schaub, G. Research and Reports in Tropical Medicine (2022) CC
This review focusses on the interactions between the etiologic agent of Chagas disease, Trypanosoma cruzi, and its triatomine vector. The flagellate mainly colonizes the intestinal tract of the insect. The effect of triatomines on trypanosomes is indicated by susceptibility and refractoriness phenom... more
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Chagas Disease Treatment Market Huge Growth in Future Scope 2023-2030

Coherent Market Insights Digital Journal (2023) C1
Coherent Market Insights has announced the addition of Chagas Disease Treatment Market 2023 Forecast Analysis by Types, Applications, Size, Share, Key Players, and Regions. a new research report to its market research archive. The Chagas Disease Treatment Market has been thoroughly researched and an... more
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Communicating with caregivers about the Human Papillomavirus vaccination

World Health Organisation (WHO) (2023) C_WHO
This training module is designed to equip health workers (HWs) with knowledge, skills, confidence and resources to help them in their role to recommend the Human Papillomavirus (HPV) vaccine.
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Congenital Chagas disease: Updated recommendations for prevention, diagnosis, treatment, and follow-up of newborns and siblings, girls, women of childbearing age, and pregnant women

Carlier, Y.; Altcheh, J.; Angheben, A. et al. PLOS Neglected Tropical Diseases (2019) CC
In 2005, the World Health Organization (WHO) recognized Chagas disease (CD; Trypanosoma cruzi infection) as a neglected tropical disease (NTD) [1] and included it into the global plan to combat NTDs [2]. The Target 3.3 of the United Nations Sustainable Development Goals (UN/SDG) aims at ending the e... more
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Chagas Disease: Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV

Panel on Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV Clinical Info HIV (2018) CC
Epidemiology Chagas disease (American trypanosomiasis) is caused by the protozoan parasite Trypanosoma cruzi, and transmitted to humans by infected triatomine bugs, and less commonly by transfusion, organ transplant, from mother to infant, and in rare instances, by ingestion of contaminated food or... more
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Chagas disease key facts

International Federation of Red Cross and Red Crescent Societies IFRC IFRC (2022) C1
About six to seven million people worldwide, mostly in Latin America, are estimated to be infected with Trypanosoma cruzi, the parasite that causes Chagas disease (WHO data from 2021). Chagas disease is found mainly in endemic areas of 21 Latin American countries. Chagas disease was once entirely ... more