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Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review

Wright J.E., Werkman M., Dunn J.C. et al Parasites and Vectors (2018) C2

Background: The human helminth infections include ascariasis, trichuriasis, hookworm infections, schistosomiasis, lymphatic filariasis (LF) and onchocerciasis. It is estimated that almost 2 billion people worldwide are infected with helminths. Whilst the WHO treatment guidelines for helminth infecti...ons are mostly aimed at controlling morbidity, there has been a recent shift with some countries moving towards goals of disease elimination through mass drug administration, especially for LF and onchocerciasis. However, as prevalence is driven lower, treating entire populations may no longer be the most efficient or cost-effective strategy. Instead, it may be beneficial to identify individuals or demographic groups who are persistently infected, often termed as being “predisposed” to infection, and target treatment at them. Methods: The authors searched Embase, MEDLINE, Global Health, and Web of Science for all English language, humanbased papers investigating predisposition to helminth infections published up to October 31st, 2017. The varying definitions used to describe predisposition, and the statistical tests used to determine its presence, are summarised. Evidence for predisposition is presented, stratified by helminth species, and risk factors for predisposition to infection are identified and discussed. Results: In total, 43 papers were identified, summarising results from 34 different studies in 23 countries. Consistent evidence of predisposition to infection with certain species of human helminth was identified. Children were regularly found to experience greater predisposition to Ascaris lumbricoides, Schistosoma mansoni and S. haematobium than adults. Females were found to be more predisposed to A. lumbricoides infection than were males. Household clustering of infection was identified for A. lumbricoides, T. trichiura and S. japonicum. Ascaris lumbricoides and T. trichiura also showed evidence of familial predisposition. Whilst strong evidence for predisposition to hookworm infection was identified, findings with regards to which groups were affected were considerably more varied than for other helminth species. Conclusion: This review has found consistent evidence of predisposition to heavy (and light) infection for certain human helminth species. However, further research is needed to identify reasons for the reported differences between demographic groups. Molecular epidemiological methods associated with whole genome sequencing to determine ‘who infects whom’ may shed more light on the factors generating predisposition. more

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Strengthening primary health care to tackle racial discrimination, promote intercultural services and reduce health inequities

World Health Organization WHO (2022) C_WHO

As countries aim to progress towards the Sustainable Development Goals (SDGs) and achieving universal health coverage, health inequities driven by racial discrimination and intersecting factors remain pervasive. Inequities experienced by indigenous peoples as well as people of African descent, Roma ... more

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Use of a Participatory Method for Community-Based Brucellosis Control Design in Agro-Pastoral Areas in Tanzania

Asakura S.; Makingi G.; John K. et al. Frontiers in Veterinary Science (2022) CC

Brucellosis is widespread in both humans and livestock in many developing countries. The authors have performed a series of epidemiological studies on brucellosis in agro-pastoral areas in Tanzania since 2015, with the aim of the disease control. Previously, the potential of a community-based brucel... more

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Covid-19 pandemic impact on maternal and child health services access in Nampula, Mozambique: a mixed methods research

das Neves Martins Pires P.H. , Macaringue C. , Abdirazak A. et al. BMC Health Services (2021) CC

The Covid-19 pandemic has so far infected more than 30 million people in the world, having major impact on global health with collateral damage. In Mozambique, a public state of emergency was declared at the end of March 2020. This has limited people's movements and reduced public services, leading ...to a decrease in the number of people accessing health care facilities. An implementation research project, The Alert Community for a Prepared Hospital, has been promoting access to maternal and child health care, in Natikiri, Nampula, for the last four years. Nampula has the second highest incidence of Covid-19. The purpose of this study is to assess the impact of Covid-19 pandemic Government restrictions on access to maternal and child healthcare services. We compared health centres in Nampula city with healthcare centres in our research catchment area. We wanted to see if our previous research interventions have led to a more resilient response from the community. METHODS: Mixed-methods research, descriptive, cross-sectional, retrospective, using a review of patient visit documentation. We compared maternal and child health care unit statistical indicators from March-May 2019 to the same time-period in 2020. We tested for significant changes in access to maternal and child health services, using KrushKall Wallis, One-way Anova and mean and standard deviation tests. We compared interviews with health professionals, traditional birth attendants and patients in the two areas. We gathered data from a comparable city health centre and the main city referral hospital. The Marrere health centre and Marrere General Hospital were the two Alert Community for a Prepared Hospital intervention sites. RESULTS: Comparing 2019 quantitative maternal health services access indicators with those from 2020, showed decreases in most important indicators: family planning visits and elective C-sections dropped 28%; first antenatal visit occurring in the first trimester dropped 26%; hospital deliveries dropped a statistically significant 4% (p = 0.046), while home deliveries rose 74%; children vaccinated down 20%. CONCLUSION: Our results demonstrated the negative collateral effects of Covid-19 pandemic Government restrictions, on access to maternal and child healthcare services, and highlighted the need to improve the health information system in Mozambique. more

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Trends in infant mortality in Venezuela between 1985 and 2016: a systematic analysis of demographic data

Jenny García, Gerardo Correa, Brenda Rousset (2019) CC

Lancet Glob Health 2019 Published Online January 24, 2019 http://dx.doi.org/10.1016/S2214-109X(18)30479-0 The health-care system collapse underway in Venezuela is a cause of utmost concern for its people and, increasingly, for the wider region. Declines in provision of basic services, such as ... more

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Burden of Severe Fungal Infections in Burkina Faso

Bamba S. , Zida A., Sangaré I. et al. Journal of Fungi (2018) CC

Because of the limited access to more powerful diagnostic tools, there is a paucity of data regarding the burden of fungal infections in Burkina Faso. The aim of this study was to estimate the incidence and prevalence of serious fungal infections in this sub-Saharan country. We primarily used the na... more

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Impact of health systems strengthening on coverage of maternal health services in Rwanda, 2000–2010: a systematic review

Maurice Bucagu, Jean M. Kagubare, Paulin Basinga, Fidèle Ngabo, Barbara K Timmons & Angela C Lee Reproductive Health Matters (2012) CC

From 2000 to 2010, Rwanda implemented comprehensive health sector reforms to strengthen the public health system, with the aim of reducing maternal and newborn deaths in line with Millennium Development Goal 5, among many other improvements in national health. Based on a systematic review of the lit... more

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Health and Environment Project in Benin

R. Edon Field Actions Science Reports (2010) C2

In 1989, the Republic of Benin was facing a great social and economical crisis. Civil servants of all the sectors in public administration were on strike. People did not know where to go for their health care. Salaries were not paid for more than six months and life for the general population wa... more

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Healthy diet

World Health Organization WHO (2020) C_WHO

Key facts - A healthy diet helps to protect against malnutrition in all its forms, as well as noncommunicable diseases (NCDs), including diabetes, heart disease, stroke and cancer. - Unhealthy diet and lack of physical activity are leading global risks to health. - Healthy dietary practices start... more

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Side-By-Side Videos for caregivers

Phila, National Department of Health South Africa National Department of Health South-Africa (2022) CC

Video is a very effective way to communicate complex concepts – like the inter-relational models Side-by-Side rests on – quickly and effectively. Side-by-Side has a small but growing collection of videos. Download and share these videos with caregivers using your social media channels, WhatsApp,... more

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Ukraine Conflict Emergency Response - Situational Report #02 (March 2022)

ChildFund Alliance and WeWorld-GVC (2022) C1

A full-scale military attack (invasion) of Ukraine was started by Russia in the night of February 23/24, 2022. Cities, towns and other targets in all regions of Ukraine have been shelled or attacked with rockets, and columns of military vehicles have been invaded the country from three directions (n... more

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The use of rectal artesunate as a pre-referral treatment for severe P. falciparum malaria: information note

World Health Organization WHO (2022) C_WHO

Available in English, French and Spanish

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L’utilisation de l’artésunate rectal comme traitement pré-transfert pour le paludisme grave à P. falciparum : note d'information

World Health Organization WHO (2022) C_WHO

Available in English, French and Spanish

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La COVID-19 chez les enfants et les adolescents : document d’information scientifique, 29 septembre 2021

Organisation Mondiale de la Santé OMS (2021) C_WHO

Les infections au SRAS-CoV-2 chez les enfants et les adolescents provoquent une maladie moins grave et moins de décès que chez les adultes. Bien qu'une évolution moins grave de l'infection soit un résultat positif, on s'inquiète du fait que des symptômes légers aient pu conduire à moins de t... more

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Handbook of Hospital Care for Newborn Infants
recommended

Maternal & Childhealth Advocacy International MCAI (2021) C1

Updated June 2021

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تفادي ضياع جيــل الــكورونــا

Unicef (2021) CC

خطة النقاط الست للاستجابة والتعافي ووضع رؤية جديدة لعالم ما بعد الجائحة لكل طفل

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Was macht die Corona-Pandemie mit Kindern und Familien?

Fegert, J.M. (2020) CC

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Coronavirus. Les Conseils de Bilou

International Federation of Red Cross and Red Crescent Societies IFRC (2020) CC

Une affiche pour enfants sur la façon de se protéger contre le Covid-19

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Coronavirus. Los consejos de Bilou

International Federation of Red Cross and Red Crescent Societies IFRC (2020) CC

Un póster para niños sobre cómo protegerse de Covid-19

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For Kids: How to keep COVID away
recommended

Asberg. S.E.; E. Chiang Lifeology (2020) C3

This visual story was created for kids to better understand the 2019 novel coronavirus and the COVID-19 illness it causes. Lifeology is a platform that brings together scientists, artists, writers and broader audiences in the creation of educational content including mobile-friendly Lifeology min... more

Handbook of Hospital Care for Newborn Infants recommended

For Kids: How to keep COVID away recommended

Handbook of Hospital Care for Newborn Infants
recommended

For Kids: How to keep COVID away
recommended