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Evaluating official development assistance-funded granting mechanisms for global health and development research that is initiated in high-income countries

Cassola, A.; Baral, P.; Røttingen, J.A.; Hoffman, S. BMC (2022) CC

Background: Several countries allocate official development assistance (ODA) for research on global health and development issues that is initiated in the donor country. The integration of such research within domestic research systems aligns with efforts to coordinate ODA investments with science, ... more

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Government policy interventions to reduce human antimicrobial use: A systematic review and evidence map

Van Katwyk, S. R.; Grimshaw, J. M.; et al (2019) C2

BACKGROUND: Growing political attention to antimicrobial resistance (AMR) offers a rare opportunity for achieving meaningful action. Many governments have developed national AMR action plans, but most have not yet implemented policy interventions to reduce antimicrobial overuse. A systematic evidenc...e map can support governments in making evidence-informed decisions about implementing programs to reduce AMR, by identifying, describing, and assessing the full range of evaluated government policy options to reduce antimicrobial use in humans. METHODS AND FINDINGS: Seven databases were searched from inception to January 28, 2019, (MEDLINE, CINAHL, EMBASE, PAIS Index, Cochrane Central Register of Controlled Trials, Web of Science, and PubMed). We identified studies that (1) clearly described a government policy intervention aimed at reducing human antimicrobial use, and (2) applied a quantitative design to measure the impact. We found 69 unique evaluations of government policy interventions carried out across 4 of the 6 WHO regions. These evaluations included randomized controlled trials (n = 4), non-randomized controlled trials (n = 3), controlled before-and-after designs (n = 7), interrupted time series designs (n = 25), uncontrolled before-and-after designs (n = 18), descriptive designs (n = 10), and cohort designs (n = 2). From these we identified 17 unique policy options for governments to reduce the human use of antimicrobials. Many studies evaluated public awareness campaigns (n = 17) and antimicrobial guidelines (n = 13); however, others offered different policy options such as professional regulation, restricted reimbursement, pay for performance, and prescription requirements. Identifying these policies can inform the development of future policies and evaluations in different contexts and health systems. Limitations of our study include the possible omission of unpublished initiatives, and that policies not evaluated with respect to antimicrobial use have not been captured in this review. CONCLUSIONS: To our knowledge this is the first study to provide policy makers with synthesized evidence on specific government policy interventions addressing AMR. In the future, governments should ensure that AMR policy interventions are evaluated using rigorous study designs and that study results are published. more

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Flexibly funding WHO? An analysis of its donors' voluntary contributions

Obichukwu I., Kennedy J., Harmer A. BMJ Global Health (2022) CC

Since the 1970s, voluntary contributions have become an increasingly important component of WHO's budget. As voluntary contributions tend to be earmarked for donor-specified programmes and projects, there are concerns that this trend has diverted focus away from WHO's strategic priorities, made coor... more

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An ethical framework for global vaccine allocation

Emanuel, E.J., et al. (2020) C1

Science . 2020 Sep 11;369(6509):1309-1312. doi: 10.1126/science.abe2803. Epub 2020 Sep 3. The Fair Priority Model offers a practical way to fulfill pledges to distribute vaccines fairly and equitably

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Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)

Henao-Restrepo, A.M.; et al. (2016)

The Lancet. Published Online December 22, 2016 http://dx.doi.org/10.1016/S0140-6736(16)32621-6. Open Access

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Comparison of national antimicrobial treatment guidelines, African Union

Craig, J.; K. Hiban, I. Frost, et al. World Health Organization WHO (2022) C_WHO

Bull World Health Organ 2022;100:50–59 | doi: http://dx.doi.org/10.2471/BLT.21.286689

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10 Insights on Climate Impacts and Peace

Detges, A.; Klingenfeld D. , König C., et al. adelphi (2020) C1

A summary of what we know

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WHO Guidelines for the Treatment of Neisseria gonorrhoeae
recommended

Santesso, N.; J. Wasserheit, H. Schünemann, et cl. World Health Organization (WHO) (2016) C_WHO

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The Core Elements of Outpatient Antibiotic Stewardship

Centers for Disease Control and Prevention CDC (2019) C_CDC

The Core Elements of Outpatient Antibiotic Stewardship provides a framework for antibiotic stewardship for outpatient clinicians and facilities that routinely provide antibiotic treatment. This report augments existing guidance for other clinical settings. In 2014 and 2015, respectively, CDC release... more

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Monitoring Global Progress on addressing Antimicrobial Resistance Analysis report of the second round of results of AMR country self-assessment survey

Food and Agriculture Organization of the United Nations FAO, World Health Organization WHO (2018) C_WHO

The global tripartite self-assessment survey of country progress in addressing antimicrobial resistance (AMR) is a component of a broader approach for monitoring and evaluation of the global action plan on AMR. This report analyses the results of the second tripartite self-assessment survey. It has ... more

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Monitoring global progess on addressing AMR

World Health Organization WHO (2018) C_WHO

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Guía de la OMS sobre detección y tratamiento de la sífilis en embarazadas

Pan American Health Organization (PAHO) (2020) C1

Las infecciones de transmisión sexual (ITS) constituyen un importante problema de salud pública en todo el mundo, que afecta a la calidad de vida y se acompaña de importantes niveles de morbilidad y mortalidad. Estas infecciones influyen directamente en la salud infantil y reproductiva porque tra... more

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Improving Health and Reducing Poverty. Disease Control Priorities, Third Edition : Volume 9.

Jamison, Dean T.; Gelband, Hellen; Horton, Susan, et al. World Bank (2017) CC

As the culminating volume in the DCP3 series, volume 9 will provide an overview of DCP3 findings and methods, a summary of messages and substantive lessons to be taken from DCP3, and a further discussion of cross-cutting and synthesizing topics across the first eight volumes. The introductory chapte... more

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Antimicrobial resistance and primary health care

World Health Organization WHO (2018) C_WHO

Despite the considerable improvement in global health, millions of people still lack access to quality health services, including access to effective antimicrobial medicines, or are impoverished as a result of health spending. At the same time, antimicrobial resistance – a consequence of overuse a... more

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Integrating Clinical Research into Epidemic Response: The Ebola Experience

Gerald Keusch, Keith McAdam, Patricia Cuff, Michelle Mancher, and Emily R. Busta National Academies of Sciences, Engineering, and Medicine (2017) C1

The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Repub... more

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The Challenges of Conducting Clinical Research on Neglected Tropical Diseases in Remote Endemic Areas in Sudan

El-Safi, S.; Chappuis, F.; Boelaert, M. PLoS Neglected Tropical diseases (2016) CC

Most neglected tropical diseases (NTDs) occur in remote areas of low- and middle-income countries, where health systems are often poorly developed. Therefore, these neglected patients generally lack access to quality preventive, diagnostic, and therapeutic care [1]. The difficulty to access NTD-ende... more