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En 2013, 289 000 femmes sont décédées pendant ou après une grossesse ou un accouchement, et 2,8 millions de nouveau-nés sont morts avant l’âge de 28 jours. La majorité de ces décès ont eu lieu dans des environnements limités en ressources et la plupart auraient pu être évités.L’acco
...
uchement est un processus complexe et il est essentiel de penser à fournir tout ce
qui est nécessaire pour garantir que la mère et le nouveau-né reçoivent les soins les plus sûrs possible. Les listes de contrôle sont des outils utiles pour organiser des processus aussi complexes et importants ; on les utilise depuis longtemps pour inciter les utilisateurs à se rappeler les tâches essentielles pour dispenser des soins plus sûrs et de meilleure qualité
dans divers contextes.
La liste OMS de contrôle pour la sécurité de l’accouchement a été élaborée comme un outil visant à améliorer la qualité des soins prodigués aux femmes qui mettent un enfant au monde
more
The year 2020 is the target date for the elimination of blinding trachoma as a public health problem. There has been great progress, and there is unprecedented funding available – particularly from DFID, the Queen Elizabeth Diamond Jubilee Trust, and USAID. There is also reason for optimism that,
...
over the next five years, further success will be seen in many endemic countries. In order to achieve elimination,
more
Abstract: Chagas disease is caused by infection with the protozoan Trypanosoma cruzi, and although over 100 years have passed since the discovery of Chagas disease, it still presents an increasing problem for global public health. A plethora of information concerning the chronic phase of human Chaga
...
s disease, particularly the severe cardiac form, is available in the literature. However, information concerning events during the acute phase of the disease is scarce. In this review, we will discuss the current status of acute Chagas disease cases globally, the immunological findings related to the acute phase and their possible influence in disease outcome, and reactivation of Chagas disease in immunocompromised individuals, a key point for transplantation and HIV invection management.
more
A key component of elimination is to reduce the number
of unmanaged trachomatous trichiasis cases to less than
1 per 1,000 population in affected areas. This will require
not only a large increase in the number of surgeries
performed, but also improvements in the quality of surgery
and in the e
...
fficiency of surgery provision programs. It also
will require that we make special efforts to reach out to
women and the most marginalized populations, who are
disproportionally affected by trichiasis (TT).
more
This motion graphic shows how the kissing bug transmits the Trypanosoma cruzi parasite to humans and causes Chagas disease.
Tsetse Control and Gambian Sleeping Sickness; Implications for Control Strategy
Tirados, I.; Esterhuizen, J.; Kovacic, V.; Mangwiro, TNC.; Vale, GA
PLOS Neglected Tropical Diseases
(2015)
CC
Sleeping sickness is controlled by case detection and treatment but this often only reaches less than 75% of the population. Vector control is capable of completely interrupting HAT transmission but is not used because of expense. We conducted a full scale field trial of a refined vector control tec
...
hnology. From preliminary trials we determined the number of insecticidal tiny targets required to control tsetse populations by more than 90%. We then carried out a full scale, 500 km2 field trial covering two HAT foci in Northern Uganda (overall target density 5.7/km2). In 12 months tsetse populations declined by more than 90%. A mathematical model suggested that a 72% reduction in tsetse population is required to stop transmission in those settings. The Ugandan census suggests population density in the HAT foci is approximately 500 per km2. The estimated cost for a single round of active case detection (excluding treatment), covering 80% of the population, is US$433,333 (WHO figures). One year of vector control organised within country, which can completely stop HAT transmission, would cost US$42,700. The case for adding this new method of vector control to case detection and treatment is strong. We outline how such a component could be organised.
more
Yaws, an infectious disease caused by Treponema pallidum subspecies pertenue, is endemic in many parts of the world. A community-wide treatment program in Papua New Guinea, in which a single dose of azithromycin was administered, showed substantial disease control. Watch the new Quick Take animation
...
. Click through to read the study.
more
Leptospirosis, a spirochaetal zoonosis, occurs in diverse epidemiological settings and affects vulnerable populations, such as rural subsistence farmers and urban slum dwellers. Although leptospirosis is a life-threatening disease and recognized as an important cause of pulmonary haemorrhage syndrom
...
e, the lack of global estimates for morbidity and mortality has contributed to its neglected disease status
more
Mycetoma: epidemiology, treatment challenges, and progress
Taha, H.; Fahal, A.; Van de Sande, W.
Dovepress open access to scientific and medical research
(2015)
CC
Mycetoma is a specific chronic, granulomatous, inflammatory disease. It usually involves the subcutaneous tissue, most probably after traumatic inoculation of the causative organism. It has a prolonged, progressive, and indolent course, and, if untreated, it ultimately leads to destruction of the de
...
eper tissues and bone, resulting in deformity and disability that may necessitate amputation of the affected parts with all the social and economic implications of this. The disease is characterized by tumefaction, draining sinuses, and the presence of grains.
more
Chromoblastomycosis (CMB) is a chronic fungal infection of the skin and the subcutaneous tissue caused by a transcutaneous traumatic inoculation of a specific group of dematiaceous fungi occurring mainly in tropical and subtropical zones worldwide. If not diagnosed at early stages, patients with CBM
...
require long term therapy with systemic antifungals, sometimes associated with physical methods. Unlike other neglected endemic mycoses, comparative clinical trials have not been performed for this disease. Nowadays, therapy is based on a few open trials and on expert opinion. Itraconazole either as monotherapy or associated with other drugs, or with physical methods, is widely used. Recently, photodynamic therapy has been successfully employed in combination with antifungals in patients presenting with CBM. In the present revision the most used therapeutic options against CBM are reviewed as well as the several factors that may have impact on the patient's outcome.
more
The major neglected tropical diseases, Taenia solium taeniosis/cysticercosis and schistosomiasis caused by Schistosoma mansoni or S. haematobium are presumed to be widely distributed in Africa. Taenia solium taeniosis/ cysticercosis has been reported as an emerging disease in different regions of Af
...
rica [1, 2], but currently the exact distribution remains unclear. Reported prevalences of T. solium taeniosis and cysticercosis in African countries are not extensive and are further complicated by the lack of ‘gold standard’ tests for diagnosis.
more
Antimicrobial resistance (AMR) represents a major threat to human health with significant global economic and security implications. In 2015, WHO Member States unanimously approved a Global Action Plan to tackle AMR (GAP-AMR). The goal of GAP-AMR is “to ensure, for as long as possible, continuity
...
of successful treatment and prevention of infectious diseases with effective and safe medicines that are quality-assured, used in a responsible way, and accessible to all who need them”.
more
The Alere Filariaisis Test Strip (FTS) is a diagnostic test used to detect filarial antigens for lymphatic filariasis. This training video was developed by ENVISION in collaboration with the US Centers for Disease Control and Prevention, with funding provided by the US Agency for International Deve
...
lopment.
more
Chikungunya virus (CHIKV) is a re-emerging mosquito borne alphavirus responsible
for the recent outbreak in the Americas. Immunologically naïve population in the Americas favors the spread of epidemics. Chikungunya fever is characterized by an abrupt febrile illness, polyarthralgia and maculopapul
...
ar rash. In chikungunya fever, shock or severe hemorrhage is very rarely observed; the onset is more acute and the duration of fever is shorter than dengue disease. The pain is much more pronounced and localized to the joints and tendons in chikungunya fever, in comparison to dengue fever. There is no specific and effective antiviral therapy and vaccines are still in trails. The only effective preventive measures consist of individual protection against mosquito bites and vector control. Disease prevention is important due to the
economic burden it entails. Clinicians need to distinguish chikungunya fever between dengue fever and other diseases to give a successful treatment and prevent disease spreading.
more
Presentation on WASH in Malawi
Chagas disease or American trypanosomiasis is, together with geohelminths, the neglected disease that causes more loss of years of healthy life due to disability in Latin America. Chagas disease, as determined by the factors and determinants, shows that different contexts require different actions,
...
preventing new cases or reducing the burden of disease. Control strategies must combine two general courses of action including prevention of transmission to prevent the occurrence of new cases (these measures are cost effective), as well as opportune diagnosis and treatment of infected individuals in order to prevent the clinical evolution of the disease and to allow them to recuperate their health. All actions should be implemented as fully as possible and with an integrated way, to maximise the impact. Chagas disease cannot be eradicated due because of the demonstrated existence of infected wild triatomines
in permanent contact with domestic cycles and it contributes to the occurrence of at least few new cases. However, it is possible to interrupt the transmission of Trypanosoma cruzi in a large territory and to eliminate Chagas disease
as a public health problem with a dramatic reduction of burden of the disease.
more
Un suivi et une évaluation efficaces sont nécessaires pour atteindre l’objectif d’élimination de la filariose lymphatique (FL). Après le traitement médicamenteux de masse (TMM) conformément aux lignes directrices élaborées par l’OMS, des programmes doivent être mis en œuvre afin de d
...
éterminer si les interventions ont permis de réduire la prévalence de l’infestation à un niveau en deçà duquel sa transmission ne pourra vraisemblablement pas perdurer. L’enquête d’évaluation
de la transmission (TAS) a été conçue de manière à offrir une structure simple et robuste afin de déterminer si la prévalence de la filariose lymphatique chez des enfants de 6–7 ans est inférieure à un seuil préalablement déterminé. Le TAS fournit aux administrateurs de programmes les informations factuelles nécessaires pour décider de l’opportunité d’arrêter le TMM. Le TAS garantit aux pouvoirs publics que les programmes nationaux ont atteint leur objectif d’élimination de la FL.
Ce guide a été conçu pour enseigner aux membres du personnel des programmes nationaux d’élimination de la FL, notamment le personnel de santé aux niveaux régional et de district, les éléments essentiels des programmes nationaux de suivi et d’évaluation pour l’élimination de la FL. Le guide est axé sur la planification et la mise en œuvre du TAS afin de pouvoir décider de l’opportunité
d’interrompre le TMM et de commencer la surveillance post-TMM.
more
Diagnosis, Case Management Prevention and Control of Leptospirosis
Monitoramento efetivo, avaliação epidemiológica e análise subsequente são
necessários para atingir o objetivo de interromper a transmissão da FL. Este manual foi
elaborado para oferecer aos programas nacionais de eliminação da fi lariose informação de qualidade sobre metodologias e proc
...
edimentos para monitoramento dos TC, avaliação adequada sobre se e quando ocorreu redução da infecção a níveis em que a transmissão provavelmente não é mais sustentável, implementação de vigilância adequada após a interrupção dos TCs para estabelecer se está ocorrendo recrudescência e medidas para comprovação da ausência de transmissão. O Manual oferece orientação geral aos programas nacionais e informações relevantes sobre questões técnicas são apresentadas nos anexos. Como as circunstâncias da vida real podem não corresponder a categorias pré-defi nidas, recomenda-se que se consultem a OMS e especialistas em situações complexas.
more
The final text of the outcome document adopted at the Third Internatinal Conference on Financing for Development (Addis Ababa, Ethiopia, 13–16 July 2015) and endorsed by the General Assembly in its resolution 69/313 of 27 July 2015.
