Investigating outbreaks caused by non-infectious, toxic agents requires some unique considerations and skills that are different from those used to investigate infectious disease outbreaks. To help public health agencies investigate these outbreaks, CDC’s National Center for Environmental Health (NCEH) has developed a Toxicological Outbreak Investigation course. The goal of the Toxicological Outbreak Investigation Course is to provide information, resources, and learning activities to impart the knowledge and skills needed to investigate a toxicological outbreak to public health practitioners who investigate outbreaks.