The document “Strategic Framework for Strengthening Cross-Border Surveillance and Information Sharing in Africa” outlines a coordinated strategy developed by Africa CDC to improve public health surveillance and collaboration across national borders in Africa. It addresses the challenge that infectious diseases often spread across borders due to population movement, trade, and migration, while surveillance systems and data-sharing mechanisms frequently remain nationally focused and fragmented. The framework proposes strengthening regional coordination, harmonizing surveillance systems, enhancing information sharing between countries, and building laboratory and workforce capacity. It also emphasizes timely detection of cross-border health threats, joint outbreak investigations, and improved communication among Member States. Overall, the document aims to enhance preparedness, early warning systems, and collective response to public health threats across the African continent.