The South African WHO Country Cooperation Strategy (CCS) 2023–2027 focuses on four key strategic priorities based on the country’s health needs and disease epidemiology, while also considering the need for building resilient health systems for UHC and health security in the post pandemic period. These include: 1. augment health systems strengthening reforms to accelerate progress towards universal health coverage. 2. address the quadruple burden of diseases and promote well-being across the life course in view of achieving global targets. 3. build health systems resilience and strengthen health emergency preparedness and response capacities. 4. enhance multisectoral collaboration and global partnerships for concerted action on health and its determinants. In order to harness its expertise across its three levels, namely: the WHO Country Office (WCO), WHO Regional Office for Africa, and WHO headquarters, WHO will work closely and collaboratively with the Government of South Africa to implement the 2023–2027 strategic priorities.