The guide is suitable and can be used for the following audiences: 1. nurses and other trained healthcare workers who can use this manual as a self-study tool and then incorporate its guidance into their practice; 2. governmental and non-governmental employers of lay and professional TB treatment adherence workers, who can provide training and guidance to their staff using the guidance in this manual; 3. TB clinicians, programme managers, policy makers and other leaders, to make them aware of the full range of interventions required by a person on TB treatment to complete his or her treatment and thus understand the gap that often exists in the support provided to patients; 4. people who, with enhanced capacity and support, can act as peer counsellors and supporters for people affected by TB. This can include family members who, in most contexts, play an important role in offering support to people with TB.