The South-East Asia Region has made remarkable progress in malaria control. Since 2010, it has achieved a 93% reduction in malaria mortality and a 76% reduction in morbidity. This success is due to strong national commitment, effective technical interventions, community engagement and substantial financial support from the Global Fund and domestic sources. Two countries, the Maldives and Sri Lanka, have achieved malaria-free status, while Bhutan and Timor-Leste are close to eliminating the disease. India, Indonesia and Myanmar are maintaining aggressive subnational strategies to sustain their progress. The region has adopted the ambitious goal of achieving malaria-free status by 2030, which is supported by the WHO Global Technical Strategy for Malaria 2016–2030, the Regional Artemisinin Resistance Initiative and a ministerial declaration on accelerating and sustaining malaria elimination. However, challenges such as artemisinin resistance and the ongoing impact of the global pandemic underscore the necessity for sustained high-level commitment, technical support, and targeted interventions to realise a malaria-free South-East Asia by 2030.