Plague is a zoonotic disease caused by the bacteria Yersinia pestis, found in small mammals. It is transmitted between animals by their fleas. The bacteria, the animal reservoir and the vector in a given area are collectively called a “plague natural focus”. Humans can become infected by being bitten by infected fleas direct contact with infected fluids or tissue from a host inhalation of respiratory droplet. This channel aims to equip frontline responders with introductory level knowledge to manage outbreaks of plague.