The IFRC Psychosocial Centre has published a guidance note providing an overview of the psychosocial consequences of virus outbreaks, with a focus on mpox, and outlines key considerations for MHPSS programming. The current mpox outbreaks present numerous challenges for responding National Societies. A key issue is addressing stigma as individuals infected, or suspected of having mpox may experience social ostracization, discrimination, and even violence. In many African communities, where cultural and social norms are vital to community health, considering the cultural and psychosocial implications of virus outbreaks is integral for effective disease management. In addition, Red Cross Red Crescent staff and volunteers may be personally exposed and working in complex environments with rumours and misinformation generating fear and anxiety. This guidance addresses the key mental health and psychosocial support implications of the ongoing mpox crisis. Guleed Dualeh, MHPSS Advisor This guidance note is intended for Red Cross Red Crescent National Societies and IFRC departments who may be responding to mpox in their country, or region. It includes guidance on: Common reactions and behaviours in epidemics Caring for staff and volunteers in health emergencies Integration of MHPSS considerations for into health responses Links to existing relevant materials