This facilitator’s manual is designed to support the implementation of the Dengue Clinical Management training course. The guide contains specific instructions for the facilitator and provides: - a detailed description of the clinical course of dengue illness, which reflects the dynamic and systemic nature of dengue that has crucial bearing on the patient’s management; - a detailed description of the basic pathophysiological changes of severe dengue (i.e. plasma leakage and hypovolaemia/shock) and guidance on the recognition of these changes and appropriate action of management; - a brief discussion on WHO classification (1997) and its limitations; - guidance on the differential diagnoses that can be confused with dengue or vice versa; they were described according to the stage of disease; - a more focused guide on the disease monitoring in accordance with the dynamic changes as the disease progresses; - emphasis on the importance of monitoring the plasma leakage (haemodynamic status of the patient, clinical signs of plasma leakage and haematocrit); - a clearer algorithm for fluid management in cases of severe dengue; and - emphasis on the importance of recognizing or suspecting significant occult bleed. Keep the facilitator’s manual with you each day as you prepare and deliver the information. Use it as a reference when delivering classroom presentations, but avoid reading directly from it during sessions.