The Lancet Regional Health - Americas 2022;00: 100248 Published online xxx https://doi.org/10.1016/j.lana.2022.100248. The Lancet Countdown report, discuss the overlapping social, climate and health challenges in Latin America and the Caribbean, and urge multisectoral and political action to transform these challenges into opportunities through adaptation and mitigation measures that place peoples’ health and wellbeing at the centre of public policies. Latin American and Caribbean governments are called upon to promote climate-resilient health care systems with adaptation plans that are tailored to guarantee quality access to care for all in this viewpoint.