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Standard operating procedures for supply chain management of health products for neglected tropical diseases amenable to preventive chemotherapy (2022)

Accuracy of Five Algorithms to Diagnose Gambiense Human African Trypanosomiasis (2011)

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Standard operating procedures for supply chain management of health products for neglected tropical diseases amenable to preventive chemotherapy (2022)

Vector control and the elimination of gambiense human African trypanosomiasis (2022)

Fexinidazole for Human African Trypanosomiasis, the Fruit of a Successful Public-Private Partnership. (2022)

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	Standard operating procedures for supply chain management of health products for neglected tropical diseases amenable to preventive chemotherapy World Health Organization WHO (2022) C_WHO View PDF(170) Download (128) Add to my MEDBOX his first edition describes the standard operating procedures for health products for NTDs amenable to preventive chemotherapy and the medicines donated to treat them. These include albendazole for lymphatic filariasis and soil-transmitted helminthiases; azithromycin for trachoma and yaws; diethylcarbamazine citrate for lymphatic filariasis; ivermectin for onchocerciasis and lymphatic filariasis; mebendazole for soil-transmitted helminthiases; praziquantel for schistosomiasis; and triclabendazole for foodborne trematodiases. Standard operating procedures for diseases amenable to case management will be covered in subsequent editions, including the application process for requesting medicines (Chapter 1). In the meantime, the procedures described in the rest of the document apply for both case management and preventive chemotherapy NTD health products Tags: NTD, Neglected Tropical Diseases (NTDs), standard operating procedures, preventive chemotherapy, chemotherapy, ivermectin, Onchocerciasis, Lymphatic filariasis, schistosoma, Schistosomiasis, praziquantel treatment, foodborne diseases, Soil-transmitted helminthiasis, triclabendazole, supply chain policy, Source: https://apps.who.int/iris/rest/bitstream
	Lignes directrices provisoires de l’OMS pour le traitement de la trypanosomiase humaine africaine à T. b. gambiense World Health Organization WHO (2019) C_WHO Open external link (220) Add to my MEDBOX Les progrès remarquables réalisés dans la lutte contre la forme à T. b. gambiense reposent sur le dépistage et le traitement curatif, une stratégie qui interrompt la transmission en réduisant le réservoir de parasites chez l’être humain. Parfois, cette approche a été combinée avec des activités de lutte antivectorielle. L’objet de ces lignes directrices est donc de la plus haute importance pour la poursuite des progrès en vue de l’élimination de la THA Tags: African Trypanosomiasis, HAT, Guidelines, recommendations, Treatment, medication, Source: https://apps.who.int/iris/bitstream/hand
	Vector control and the elimination of gambiense human African trypanosomiasis World Health Organization WHO (2022) C_WHO View PDF(147) Download (74) Add to my MEDBOX The main purpose of the meeting was to review tsetse control tools, activities and their contribution to the elimination of gHAT and the monitoring thereof. Seven endemic countries provided reports on recent and ongoing vector control interventions at the national level (Angola, Cameroon, Côte d’Ivoire, Chad, Democratic Republic of the Congo, Guinea and Uganda). Country reports focused on the in situations implementing and supporting vector control activities, the tools and the approaches in use, the coverage of the activities in space and time and their impacts on tsetse populations. Future perspectives for vector control in the respective countries were also discussed, including opportunities and challenges to sustainability Tags: Elimination, HAT, African Trypanosomiasis, Vector Control, interventions, control, tsetse fly, NTD, Neglected Tropical Diseases (NTDs), Source: https://apps.who.int/iris/rest/bitstream
	Fexinidazole for Human African Trypanosomiasis, the Fruit of a Successful Public-Private Partnership. Bernhard, S.; Kaiser, M.; Burri, C.; Mäser, P. Diseases (2022) CC Open external link (327) Add to my MEDBOX After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery, pre-clinical development, and operational challenges of the clinical trials of fexinidazole. The screening of the Drugs for Neglected Diseases initiative (DNDi) HAT-library by the Swiss TPH had singled out fexinidazole, originally developed by Hoechst (now Sanofi), as the most promising of a series of over 800 nitroimidazoles and related molecules. In cell culture, fexinidazole has an IC50 of around 1 µM against Trypanosoma brucei and is more than 100-fold less toxic to mammalian cells. In the mouse model, fexinidazole cures both the first, haemolymphatic, and the second, meningoencephalitic stage of the infection, the latter at 100 mg/kg twice daily for 5 days. In patients, the clinical trials managed by DNDi and supported by Swiss TPH mainly conducted in the Democratic Republic of the Congo demonstrated that oral fexinidazole is safe and effective for use against first- and early second-stage sleeping sickness. Based on the positive opinion issued by the European Medicines Agency in 2018, the WHO has released new interim guidelines for the treatment of HAT including fexinidazole as the new therapy for first-stage and non-severe second-stage sleeping sickness caused by Trypanosoma brucei gambiense (gHAT). This greatly facilitates the diagnosis and treatment algorithm for gHAT, increasing the attainable coverage and paving the way towards the envisaged goal of zero transmission by 2030 Tags: African Trypanosomiasis, Treatment, journal article, Source: https://www.mdpi.com/2079-9721/10/4/90
	Accuracy of Five Algorithms to Diagnose Gambiense Human African Trypanosomiasis Francesco Checchi, Francois Chappuis, Unni Karunakara, Gerardo Priotto, Daniel Chandramohan (2011) C1 Open external link (3296) Add to my MEDBOX Plos Neglected Tropical Diaseses, vol. 5 (2011) Issue 7 e1233. Open Access. Please download from the website Tags: HAT, Laboratory diagnostics, Source: http://fieldresearch.msf.org/msf/bitstre

5 records

5 records