Nat Commun 9, 5370 (2018). https://doi.org/10.1038/s41467-018-07804-8. Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are... limited to antibiotics with severe side effects. Here, we show that M. ulcerans is susceptible to the anti-tubercular drug Q203 and related compounds targeting the respiratory cytochrome bc1:aa3. While the cytochrome bc1:aa3 is the primary terminal oxidase in Mycobacterium tuberculosis, the presence of an alternate bd-type terminal oxidase limits the bactericidal and sterilizing potency of Q203 against this bacterium. M. ulcerans strains found in Buruli ulcer patients from Africa and Australia lost all alternate terminal electron acceptors and rely exclusively on the cytochrome bc1:aa3 to respire. As a result, Q203 is bactericidal at low dose against M. ulcerans replicating in vitro and in mice, making the drug a promising candidate for Buruli ulcer treatment.
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A short movie about the history and the current status of antibiotics from the four week online course: Antibiotic Resistance: the silent tsunami, produced by ReAct and Uppsala University, Sweden.
Six months after the earthquake, World Vision's efforts have made it possible to provide emergency assistance to selected beneficiaries among the most vulnerable through the distribution of food and hygiene kits and to address the psychosocial needs of children, adolescents, and young people deprive...d of classrooms. During this recovery phase of the response by World Vision teams have been focusing on rebuilding and rehabilitating school infrastructure in order to facilitate the return to school in safer conditions given the almost permanent seismic risks. Six months later, the security situation continues to deteriorate with an increase in kidnappings and nationwide strikes to protest against the rising insecurity.
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The main objectives of the SOPs are to: (i) establish standards and timelines for response activities; and (ii) guide national governments and GPEI partners in key support functions.
This new version of the SOPs presents overall response requirements for dealing with type 1, 2 and 3 poliovirus fo...llowing monovalent type 2 oral polio vaccine (mOPV2) cessation. Version 2.4 will be valid until release of revised version 3.0 (anticipated May 2018).
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The Multi-Cluster/Sector Initial Rapid Assessment (MIRA) is a joint needs assessment tool that can be used in sudden onset emergencies, including IASC System-Wide Level 3 Emergency Responses (L3 Responses).
Опыт предыдущих вспышек инфекционных заболеваний указывает на то, что новые риски
для защиты детей могут возникать как в результате прямого воздействия COVID-19, так ...и
в результате мер по предотвращению и контролю его распространения. Кроме того, существующие риски для защиты детей, вероятно, будут усугублены. Некоторые группы людей более уязвимы в этих обстоятельствах, в том числе, как указано в данной Технической записке, дети, лишенные свободы, у которых зачастую возникают риски с вопросами психосоциального, физического и психического здоровья, которые живут в людных или негигиеничных условиях и больше подвержены жестокому обращению, насилию и халатному отношению.
Technical note: COVID-19 and children deprived of their liberty
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Independent Monitoring Board of the Global Polio Eradication Initiative (Twelfth Report: October 2015)
Paper commissioned for Fixing the Broken Promise of Education for All: Findings from the Global Initiative on Out-of-School Children
Science / People / Progress
Accessed: 12.11.2019
(Research Report)
This assessment relies on semi-structured interviews with 28 purposely-selected Afghan returnees who migrated to Europe and returned to Afghanistan between 2014 and 2017. Through these interviews, the assessment seeks to better understand the socio-economic profile of Afghans retu...rning from Europe, to identify the motivations behind their return, and to investigate the challenges and vulnerabilities they face once they arrive in Afghanistan.
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Testimonies from Humanitarian Workers with Disabilities.
By reading the first-hand accounts, we hear how persons with disabilities, not through any particular talent or skill but from unique knowledge gained through life experience, are ideally placed to provide insights, ideas and leadership, to s...upply essential data, and to fill the gaps in humanitarian response that cause this exclusion.
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Cureus 2024 Jan 16;16(1):e52358. doi: 10.7759/cureus.52358
mBio, Vol. 6 Issue 2, March/April 2015
Available evidence demonstrates that direct patient contact and contact with infectious body fluids are the primary modes for Ebola virus transmission, but this is based on a limited number of studies. In this review, the authors address what we know and what ...we do not know about Ebola virus transmission. They also hypothesize that Ebola viruses have the potential to be respiratory pathogens with primary respiratory spread.
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MMWR Morbidity and Mortality Weekly Report December 19, 2014 / 63(50);1205-1206
N Engl J Med 2022; 386:911-922, DOI: 10.1056/NEJMoa2104535
Four months of antituberculosis treatment was noninferior to 6 months of treatment in children with drug-susceptible, nonsevere, smear-negative tuberculosis (SHINE Study)
PLoSONE 14(9):e0223104.https://doi.org/10.1371/journal.pone.0223104.
The survey centering on reasons behind community resistance was conducted in Butembo in November during a time of Ebola transmission. A researcher from Catholic University of Graben in Butembo and collaborators at the University o...f Alberta in Edmonton published their findings on Sep 26 in PLOS One.
To spark focus group discussions, the researchers used an 18-item questionnaire based on similar ones used during West Africa's outbreak in Guinea, where community resistance and episodes of violence also complicated the outbreak response.
Participants were a convenience sample of 670 adults from the region who were recruited by medical students at Catholic University of Graben. Those surveyed included clinicians, community members, and displaced persons.
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