After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery, pre-clinical development, and operational challenge...s of the clinical trials of fexinidazole. The screening of the Drugs for Neglected Diseases initiative (DNDi) HAT-library by the Swiss TPH had singled out fexinidazole, originally developed by Hoechst (now Sanofi), as the most promising of a series of over 800 nitroimidazoles and related molecules. In cell culture, fexinidazole has an IC50 of around 1 µM against Trypanosoma brucei and is more than 100-fold less toxic to mammalian cells. In the mouse model, fexinidazole cures both the first, haemolymphatic, and the second, meningoencephalitic stage of the infection, the latter at 100 mg/kg twice daily for 5 days. In patients, the clinical trials managed by DNDi and supported by Swiss TPH mainly conducted in the Democratic Republic of the Congo demonstrated that oral fexinidazole is safe and effective for use against first- and early second-stage sleeping sickness. Based on the positive opinion issued by the European Medicines Agency in 2018, the WHO has released new interim guidelines for the treatment of HAT including fexinidazole as the new therapy for first-stage and non-severe second-stage sleeping sickness caused by Trypanosoma brucei gambiense (gHAT). This greatly facilitates the diagnosis and treatment algorithm for gHAT, increasing the attainable coverage and paving the way towards the envisaged goal of zero transmission by 2030.
more
HelpAge International es una red global de organizaciones que promueve el derecho de todas las personas mayores a llevar vidas dignas, saludables y seguras. Convite es una organización humanitaria, independiente, sin ánimo de lucro y no gubernamental que trabaja para garantizar y promover los dere...chos sociales, económicos y culturales en toda Venezuela y es un nuevo miembro de la Red Global HelpAge. Convite brinda apoyo directo a las personas mayores, además de ayudar al Comité Nacional de Jubilados y Pensionistas de Venezuela como parte de la Red Latinoamericana de Democracia. Uno de los principales objetivos de la organización es elevar el perfil de la crisis internacional en el país.
more
Уроки эпидемии ВИЧ-инфекции: эффективное реагирование силами сообщества
Human rights in times of COVID-19
Сотрудники структурного подразделения Московского института психоанализа "Виртуальная Клиника", а также группа специалистов Московского государственного униве...ситета им М.В. Ломоносова и Московского научно-практического центра наркологии Департамента здравоохранения Москвы запустили Программу дистанционных волонтерских групп взаимопомощи населению в период самоизоляции и режима повышенной готовности.
more
Operation update 01/04/2022
Men are less likely than women to seek help for mental health issues and are much more likely to commit suicide. This scoping review examined recent evidence published in English and Russian on the role of socially constructed masculinity norms in men’s help-seeking behaviour for mental health iss...ues. The key sociocultural barriers to men’s help-seeking pertaining to masculinity norms were identified as self-reliance, difficulty in expressing emotions and self-control.
more
Способы, которые могут помочь вам предотвратить распространение коронавирусной инфекции COVID-19 при совместном пользовании автомобилем
Carpoooling and COVID-19
Workshop Report: Dhaka, Bangladesh 12-15 June 2023
Правила безопасного ношения медицинских масок: что следует делать и чего не следуе
Инфографика
MedPPE emphasizes the role and timing of health workers jobs and offers specific information to prevent the spread of COVID-19. The guidelines are aimed at all personnel working in health facilities, including security guards, administrative and cleaning personnel, transfer assistants, nurses, biome...dical and imaging technicians, surgeons, and physicians, among others.
MedPPE provides guidance for the use of PPE according to workers’ function, the level of care they provide, and the multiple environments of primary health care and hospitals. The tool also clarifies the type of PPE needed when performing aerosol-generating procedures and other activities related to the care of patients infected or suspected of being infected with COVID-19.
However, use of PPE alone is not enough to protect against COVID-19. Hand hygiene and proper PPE dressing and undressing procedures must also be followed, along with the proper disposal and management of waste.
MedPPE is available in Spanish, English, Portuguese and French for iOS and Android devices.
more
HelpAge International is a global network of organisations promoting the right of all older people to lead dignified, healthy and secure lives. Convite is a humanitarian, independent, nonprofit, non-governmental organisation that works to guarantee and promote social, economic and cultural rights ac...ross Venezuela and is a new member of the HelpAge Global Network. Convite provides direct support to older people, as well as assisting the National Committee of the Pensioned and Retired of Venezuela as part of the Latin American Democracy Network. One of the organisation’s main objectives is to the raise the profile of the crisis in the country internationally.
more